个人简介

I am a theoretical physicist with a PhD in Theoretical Biology and Biophysics (Humboldt Univeristy of Berlin, Germany). Research is one of the things I love the most, along with teaching and sports. Our research group in Systems Medicine, is an interdisciplinary team with skills in Immunology, Mathematical Modelling, Statistics and Bioinformatics to study human viral infections. This research contributes to better understanding of transmission of viral infections, immune responses against hepatitis viruses and influenza, as well as in developing bioinformatics and statistical tools for analysis of genomics and immunology high throughput data. The rapid advancement in high-throughput technologies, such as single cell analysis and next generation sequencing, has lead to complex large data-sets, which demand for quantitative skills to interpret data. We have established a unique combination of these new methodologies and systems analyses to address key questions that classical immune-virology experimental approaches alone could not resolve. I have developed novel computational models to analysis viral genomes using next-generation deep sequencing, which led to novel insights on HCV infections, as well as on the translational application of these technologies in terms of monitoring outbreak, drug resistance

研究领域

Infectious Diseases

I am interested in Evolutionary dynamics of infectious diseases, Bioinformatics, Mathematical models, Statistical inference of biologically relevant quantities. In our lab we are always interested in new talented PhD and Master students. Please email me if interested. Systems Immunology Next generation Sequencing Our group is very much interested in Next Generation Sequencing (NGS) applied to HCV viral dynamics. This technique allows the detection of rare species of the virus and therefore allows a detailed quantification of viral evolution. We are using NGS to also detect escape mutants that avoid immune responses causing chronic infections. Single cell isolation and SIngle cell transcriptomics. This is our new interest. We are studying how antigen speciifc T cells change their phenotype upon antigen encounter, and how these cells further develop into protective memory cells. Bioinformatics software Please, contact me for more information and for few computer programs that I developed with my collaborators. Hepatitis C virus and its evolutionary dynamics I am interested in modeling of Hepatitis C virus dynamics. HCV is a rapidly mutating virus with fascinating dynamics. It can evolve very quickly within a host and escape immune responses. My interest is in the population dynamics and epidemiology of HCV infections and in understanding the role of host heterogeneity in driving viral evolution. For instance, I am working on the role of MHC frequency distribution and its effect in determining the probability of escape mutants. T cell dynamics and Antigen presentation I am interested in the mechanisms behind antigen processing and presentation in the context of MHC class I response. I am working on a project in collaboration with Ass Prof Katherine Kedzierska (Peter Doherty Institute in Melbourne) on the dynamical evolution of immunodominance in T cell responses against influenza virus. T cell trafficking in the liver We are also interested in T cell trafficking and in the T cell driven immune response in the liver. This project is in collaboration with Dr Patrick Bertolino and Dr David Bowen at the Centenary Institute (University of Sydney). Public Health/Epidemiology Statistical analyses of hepatitis C virus in injecting drug users Epidemiological and statistical analyses of a large cohort of HCV infected subjects in NSW prisons, the Hepatitis C Incidence and Transmission Study (HITS). Currently, I am responsible for the statistical analyses of a large epidemiological, virological and immunological dataset on early evolution of the virus in these subjects, see my publications. Molecular Epidemiology A great application of mathematical models of infectious diseases is the study of transmission dynamics of complex pathogens, such as bacteria. Given their complex genomes, it is often hard to study directly changes in the DNA sequence of these organisms. Therefore scientists have come up with few typing scheme.

近期论文

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Betz-Stablein BD; Töpfer A; Littlejohn M; Yuen L; Colledge D; Sozzi V; Angus P; Thompson A; Revill P; Beerenwinkel N; Warner N; Luciani F, 2016, 'Single-molecule sequencing reveals complex genome variation of hepatitis B virus during 15 Years of chronic infection following liver transplantation', Journal of Virology, vol. 90, no. 16, pp. 7171 - 7183, http://dx.doi.org/10.1128/JVI.00243-16 Luciani F, 2016, 'High-throughput sequencing and vaccine design', OIE Revue Scientifique et Technique, vol. 35, no. 1, pp. 53 - 65, http://dx.doi.org/10.20506/rst.35.1.2417 Walker MR; Li H; Teutsch S; Betz-Stablein B; Luciani F; Lloyd AR; Bull RA, 2016, 'Incident hepatitis c virus genotype distribution and multiple infection in australian prisons', Journal of Clinical Microbiology, vol. 54, no. 7, pp. 1855 - 1861, http://dx.doi.org/10.1128/JCM.00287-16 Fiches GN; Eyre NS; Aloia AL; Van Der Hoek K; Betz-Stablein B; Luciani F; Chopra A; Beard MR, 2016, 'HCV RNA traffic and association with NS5A in living cells', Virology, vol. 493, pp. 60 - 74, http://dx.doi.org/10.1016/j.virol.2016.02.016 Bull RA; Eltahla AA; Rodrigo C; Koekkoek SM; Walker M; Pirozyan MR; Betz-Stablein B; Toepfer A; Laird M; Oh S; Heiner C; Maher L; Schinkel J; Lloyd AR; Luciani F, 2016, 'A method for near full-length amplification and sequencing for six hepatitis C virus genotypes', BMC Genomics, vol. 17, no. 1, http://dx.doi.org/10.1186/s12864-016-2575-8 Eltahla AA; Rizzetto S; Pirozyan MR; Betz-Stablein BD; Venturi V; Kedzierska K; Lloyd AR; Bull RA; Luciani F, 2016, 'Linking the T cell receptor to the single cell transcriptome in antigen-specific human T cells', Immunology and Cell Biology, vol. 94, no. 6, pp. 604 - 611, http://dx.doi.org/10.1038/icb.2016.16 Audsley J; Bent SJ; Littlejohn M; Avihingsanon A; Matthews G; Bowden S; Bayliss J; Luciani F; Yuen L; Fairley CK; Locarnini S; Lewin SR; Sasadeusz J, 2016, 'Effects of long-term tenofovir-based combination antiretroviral therapy in HIV-hepatitis B virus coinfection on persistent hepatitis B virus viremia and the role of hepatitis B virus quasispecies dive', AIDS, vol. 30, no. 10, pp. 1597 - 1606, http://dx.doi.org/10.1097/QAD.0000000000001080 Mina MM; Cameron B; Luciani F; Vollmer-Conna U; Lloyd AR, 2016, 'Natural killer cells in highly exposed hepatitis C-seronegative injecting drug users', Journal of Viral Hepatitis, vol. 23, no. 6, pp. 464 - 472, http://dx.doi.org/10.1111/jvh.12511 Bartlett SR; Jacka B; Bull RA; Luciani F; Matthews GV; Lamoury FMJ; Hellard ME; Hajarizadeh B; Teutsch S; White B; Maher L; Dore GJ; Lloyd AR; Grebely J; Applegate TL, 2016, 'HIV infection and hepatitis C virus genotype 1a are associated with phylogenetic clustering among people with recently acquired hepatitis C virus infection', Infection, Genetics and Evolution, vol. 37, pp. 252 - 258, http://dx.doi.org/10.1016/j.meegid.2015.11.028 Youngson NA; Lecomte V; Maloney CA; Leung P; Liu J; Hesson LB; Luciani F; Krause L; Morris MJ, 2015, 'Obesity-induced sperm DNA methylation changes at satellite repeats are reprogrammed in rat offspring.', Asian Journal of Andrology, http://dx.doi.org/10.4103/1008-682X.163190 Eltahla AA; Luciani F; White PA; Lloyd AR; Bull RA, 2015, 'Inhibitors of the hepatitis C virus polymerase; mode of action and resistance', Viruses, vol. 7, no. 10, pp. 5206 - 5224, http://dx.doi.org/10.3390/v7102868 Applegate TL; Gaudieri S; Plauzolles A; Chopra A; Grebely J; Lucas M; Hellard M; Luciani F; Dore GJ; Matthews GV, 2015, 'Naturally occurring dominant drug resistance mutations occur infrequently in the setting of recently acquired hepatitis C', Antiviral Therapy, vol. 20, no. 2, pp. 199 - 208, http://dx.doi.org/10.3851/IMP2821 Bretaña NA; Boelen L; Bull R; Teutsch S; White PA; Lloyd AR; Luciani F; HITS-p investigators, 2015, 'Transmission of Hepatitis C Virus among Prisoners, Australia, 2005-2012.', Emerging Infectious Diseases, vol. 21, no. 5, pp. 765 - 774, http://dx.doi.org/10.3201/eid2105.141832 Bull RA; Leung P; Gaudieri S; Deshpande P; Cameron B; Walker M; Chopra A; Lloyd AR; Luciani F; Dolan K; Haber P; Rawlinson W; Treloar C; Dore G; Maher L, 2015, 'Transmitted/founder viruses rapidly escape from CD8⁺ T cell responses in acute hepatitis C virus infection', Journal of Virology, vol. 89, no. 10, pp. 5478 - 5490, http://dx.doi.org/10.1128/JVI.03717-14 Zarzour P; Boelen L; Luciani F; Beck D; Sakthianandeswaren A; Mouradov D; Sieber OM; Hawkins NJ; Hesson LB; Ward RL; Wong JWH, 2015, 'Single nucleotide polymorphism array profiling identifies distinct chromosomal aberration patterns across colorectal adenomas and carcinomas', Genes Chromosomes and Cancer, vol. 54, no. 5, pp. 303 - 314, http://dx.doi.org/10.1002/gcc.22243 Mina MM; Luciani F; Cameron B; Bull RA; Beard MR; Booth D; Lloyd AR, 2015, 'Resistance to hepatitis C virus: Potential genetic and immunological determinants', Lancet Infectious Diseases, http://dx.doi.org/10.1016/S1473-3099(14)70965-X Luciani F; Bretaña NAR; Teutsch S; Amin J; Topp L; Dore GJ; Maher L; Dolan K; Lloyd AR, 2014, 'A prospective study of hepatitis C incidence in Australian prisoners', Addiction, vol. 109, no. 10, pp. 1695 - 1706, http://dx.doi.org/10.1111/add.12643 Sugden PB; Cameron B; Mina M; Lloyd AR, 2014, 'Protection against hepatitis C infection via NK cells in highly-exposed uninfected injecting drug users', Journal of Hepatology, vol. 61, no. 4, pp. 738 - 745, http://dx.doi.org/10.1016/j.jhep.2014.05.013 Tu T; Budzinska M; McCaughan GW; McLennan SV; Luciani F; Shackel N, 2014, 'DELETERIOUS PASSENGER MUTATIONS AS A BIOMARKER FOR HEPATOCELLULAR CARCINOMA', Asia Pacific Journal of Clinical Oncology, vol. 10, pp. 44 - 44, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000344745100124&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a Ayres A; Yuen L; Jackson KM; Manoharan S; Glass A; Maley M; Yoo W; Hong SP; Kim SO; Luciani F; Bowden DS; Bayliss J; Levy MT; Locarnini SA, 2014, 'Short duration of lamivudine for the prevention of hepatitis B virus transmission in pregnancy: Lack of potency and selection of resistance mutations', Journal of Viral Hepatitis, vol. 21, no. 11, pp. 809 - 817, http://dx.doi.org/10.1111/jvh.12212