研究领域

Pharmacology and Pharmaceutical Sciences

The broad interest of the lab is concerning cancer pharmacology, experimental therapeutics, targeted cancer therapy, pharmacokinetics, drug transport, chemotherapy-induced neuropathy and caner risk related genetic polymorphisms. In particular, we have been involving in the preclinical development of anticancer agents, including small molecules targeting Wnt signalling, copper chelators, platinum/gold/silver-based complexes, vascular-disrupting flavonoids and mulberry fruit extracts using a variety of in vitro and in vivo approaches. We are among the first to identify the links of copper transporters and organic cation transporters with chemotherapy-induced neurotoxicity, and lung cancer risk related genetic polymorphisms in Chinese Han population. We have current research projects for PhD, Masters, Honours and ILP students on the topics of targeting Wnt signalling and drug transporters in cancer therapy.

近期论文

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Zhang S; Gao L; Thakur A; Shi P; Liu F; Feng J; Wang T; Liang Y; Liu JJ; Chen M; Ren H, 2016, 'miRNA-204 suppresses human non-small cell lung cancer by targeting ATF2', Tumor Biology: from basic science to clinical application, pp. 1 - 10, http://dx.doi.org/10.1007/s13277-016-4906-4 Yan F; Liu JJ; Ip V; Jamieson SMF; McKeage MJ, 2015, 'Role of platinum DNA damage-induced transcriptional inhibition in chemotherapy-induced neuronal atrophy and peripheral neurotoxicity', Journal of Neurochemistry, vol. 135, no. 6, pp. 1099 - 1112, http://dx.doi.org/10.1111/jnc.13355 Yan F; Liu JJ; Ip V; Jamieson SMF; Mckeage MJ, 2015, 'Role of platinum DNA damage-induced transcriptional inhibition in chemotherapy-induced neuronal atrophy and peripheral neurotoxicity', Journal of Neurochemistry, http://dx.doi.org/10.1111/jnc.13355 Qian Z; Wu Z; Huang L; Qiu H; Wang L; Li L; Yao L; Kang K; Qu J; Wu Y; Luo J; Liu JJ; Yang Y; Yang W; Gou D, 2015, 'Mulberry fruit prevents LPS-induced NF-κB/pERK/MAPK signals in macrophages and suppresses acute colitis and colorectal tumorigenesis in mice', Scientific Reports, vol. 5, http://dx.doi.org/10.1038/srep17348 Zhang S; Thakur A; Liang Y; Wang T; Gao L; Yang T; Li Y; Geng T; Jin T; Chen T; Liu JJ; Chen M, 2015, 'Polymorphisms in C-reactive protein and glypican-5 are associated with lung cancer risk and gartrokine-1 influences cisplatin-based chemotherapy response in a Chinese Han population', Disease Markers, vol. 2015, http://dx.doi.org/10.1155/2015/824304 Wang T; Chen T; Thakur A; Liang Y; Gao L; Zhang S; Tian Y; Jin T; Liu JJ; Chen M, 2015, 'Association of PSMA4 polymorphisms with lung cancer susceptibility and response to cisplatin-based chemotherapy in a Chinese Han population', Clinical and Translational Oncology, vol. 17, no. 7, pp. 564 - 569, http://dx.doi.org/10.1007/s12094-015-1279-x Cui H; Zhang AJ; Chen M; Liu JJ, 2015, 'ABC transporter inhibitors in reversing multidrug resistance to chemotherapy', Current Drug Targets, vol. 16, no. 12, pp. 1356 - 1371 Gao L; Thakur A; Liang Y; Zhang S; Wang T; Chen T; Meng J; Wang L; Wu F; Jin T; Li X; Liu JJ; Chen C; Chen M, 2014, 'Polymorphisms in the TERT gene are associated with lung cancer risk in the Chinese Han population', European Journal of Cancer Prevention, vol. 23, no. 6, pp. 497 - 501, http://dx.doi.org/10.1097/CEJ.0000000000000086 Liu JJ; Kim Y; Yan F; Ding Q; Ip V; Jong NN; Mercer JFB; McKeage MJ, 2013, 'Contributions of rat Ctr1 to the uptake and toxicity of copper and platinum anticancer drugs in dorsal root ganglion neurons', Biochemical Pharmacology, vol. 85, no. 2, pp. 207 - 215, http://dx.doi.org/10.1016/j.bcp.2012.10.023 Ip V; Liu JJ; Mckeage MJ, 2013, 'Evaluation of effects of copper histidine on copper transporter 1-mediated accumulation of platinum and oxaliplatin-induced neurotoxicity in vitro and in vivo', Clinical and Experimental Pharmacology and Physiology, vol. 40, no. 6, pp. 371 - 378, http://dx.doi.org/10.1111/1440-1681.12088 Liu JJ; Lu J; McKeage MJ, 2012, 'Membrane transporters as determinants of the pharmacology of platinum anticancer drugs', Current Cancer Drug Targets, vol. 12, no. 8, pp. 962 - 986, http://dx.doi.org/10.2174/156800912803251199 Jong NN; Nakanishi T; Liu JJ; Tamai I; McKeage MJ, 2011, 'Oxaliplatin transport mediated by organic cation/carnitine transporters OCTN1 and OCTN2 in overexpressing human embryonic kidney 293 cells and rat dorsal root ganglion neurons', Journal of Pharmacology and Experimental Therapeutics, vol. 338, no. 2, pp. 537 - 547, http://dx.doi.org/10.1124/jpet.111.181297 Ip V; Liu JJ; Mercer JFB; McKeage MJ, 2010, 'Differential expression of ATP7A, ATP7B and CTR1 in adult rat dorsal root ganglion tissue', Molecular Pain, vol. 6, http://dx.doi.org/10.1186/1744-8069-6-53 Jamieson SMF; Subramaniam J; Liu JJ; Jong NN; Ip V; Connor B; McKeage MJ, 2009, 'Oxaliplatin-induced loss of phosphorylated heavy neurofilament subunit neuronal immunoreactivity in rat DRG tissue', Molecular Pain, vol. 5, http://dx.doi.org/10.1186/1744-8069-5-66 Liu JJ; Jamieson SMF; Subramaniam J; Ip V; Jong NN; Mercer JFB; McKeage MJ, 2009, 'Neuronal expression of copper transporter 1 in rat dorsal root ganglia: Association with platinum neurotoxicity', Cancer Chemotherapy and Pharmacology, vol. 64, no. 4, pp. 847 - 856, http://dx.doi.org/10.1007/s00280-009-1017-6 Bell DN; Liu JJ; Tingle MD; Rattel B; Meyer TU; McKeage MJ, 2008, 'Comparative protein binding, stability and degradation of satraplatin, JM118 and cisplatin in human plasma in vitro', Clinical and Experimental Pharmacology and Physiology, vol. 35, no. 12, pp. 1440 - 1446, http://dx.doi.org/10.1111/j.1440-1681.2008.05017.x Ip V; McKeage MJ; Thompson P; Damianovich D; Findlay M; Liu JJ, 2008, 'Platinum-specific detection and quantification of oxaliplatin and Pt(R,R-diaminocyclohexane)Cl2 in the blood plasma of colorectal cancer patients', Journal of Analytical Atomic Spectrometry, vol. 23, no. 6, pp. 881 - 884, http://dx.doi.org/10.1039/b716925f Liu JJ; Galettis P; Farr A; Maharaj L; Samarasinha H; McGechan AC; Baguley BC; Bowen RJ; Berners-Price SJ; McKeage MJ, 2008, 'In vitro antitumour and hepatotoxicity profiles of Au(I) and Ag(I) bidentate pyridyl phosphine complexes and relationships to cellular uptake', Journal of Inorganic Biochemistry, vol. 102, no. 2, pp. 303 - 310, http://dx.doi.org/10.1016/j.jinorgbio.2007.09.003 Jamieson SMF; Liu JJ; Connor B; Dragunow M; McKeage MJ, 2007, 'Nucleolar enlargement, nuclear eccentricity and altered cell body immunostaining characteristics of large-sized sensory neurons following treatment of rats with paclitaxel', NeuroToxicology, vol. 28, no. 6, pp. 1092 - 1098, http://dx.doi.org/10.1016/j.neuro.2007.04.009 Liu JJ; Ching LM; Goldthorpe M; Sutherland R; Baguley BC; Kirker JA; McKeage MJ, 2007, 'Antitumour action of 5,6-dimethylxanthenone-4-acetic acid in rats bearing chemically induced primary mammary tumours', Cancer Chemotherapy and Pharmacology, vol. 59, no. 5, pp. 661 - 669, http://dx.doi.org/10.1007/s00280-006-0321-7