研究领域

Animal Neurobiology

The overarching goal of my research is to provide a better understanding of the cellular and physiological mechanisms used by autonomic systems; cardiovascular, respiratory and glucoregulatory. Physiological reflexes (e.g. baroreflex, chemoreflex, glucose counterregulation) function to maintain homeostasis. They are integrated by neuronal circuits in the brain, and their long term and short term patency is continually regulated by genetic and environmental factors. Pathological regulation can form the basis for disease (respiratory disorders, hypertension, diabetes). How do homeostatic systems - which are vital for survival - adapt to changing environmental conditions? How do environmental challenges contribute to neuronal excitability, physiological processes and drug action? I have significant expertise in cutting-edge tools and techniques (molecular methods, mouse genetics, imaging techniques, viral mediated gene rescue and knockdown) that are currently revolutionizing neuroscience. I use these skills to interrogate alterations in autonomic systems following physiological/environmental stress and provide avenues for therapy based on molecular understanding of disease processes.

近期论文

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Guyenet PG; Bayliss DA; Stornetta RL; Ludwig MG; Kumar NN; Shi Y; Burke PGR; Kanbar R; Basting TM; Holloway BB; Wenker IC, 2016, 'Proton detection and breathing regulation by the retrotrapezoid nucleus', The Journal of Physiology, vol. 594, no. 6, pp. 1529 - 1551, http://dx.doi.org/10.1113/JP271480 Le S; Turner AJ; Parker LM; Burke PG; Kumar NN; Goodchild AK; McMullan S, 2016, 'Somatostatin 2a receptors are not expressed on functionally identified respiratory neurons in the ventral respiratory column of the rat', Journal of Comparative Neurology, vol. 524, no. 7, pp. 1384 - 1398, http://dx.doi.org/10.1002/cne.23912 Le S; Turner AJ; Parker LM; Burke PG; Kumar NN; Goodchild AK; Mcmullan S, 2015, 'Somatostatin 2a receptors are not expressed on functionally identified respiratory neurons in the ventral respiratory column of the rat', Journal of Comparative Neurology, http://dx.doi.org/10.1002/cne.23912 Kumar NN; Velic A; Soliz J; Shi Y; Li K; Wang S; Weaver JL; Sen J; Abbott SBG; Lazarenko RM; Ludwig MG; Perez-Reyes E; Mohebbi N; Bettoni C; Gassmann M; Suply T; Seuwen K; Guyenet PG; Wagner CA; Bayliss DA, 2015, 'Regulation of breathing by CO2 requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons', Science, vol. 348, no. 6240, pp. 1255 - 1260, http://dx.doi.org/10.1126/science.aaa0922 Bowman BR; Kumar NN; Hassan SF; McMullan S; Goodchild AK, 2013, 'Brain sources of inhibitory input to the rat rostral ventrolateral medulla', Journal of Comparative Neurology, vol. 521, no. 1, pp. 213 - 232, http://dx.doi.org/10.1002/cne.23175 Pardey MC; Kumar NN; Goodchild AK; Cornish JL, 2013, 'Catecholamine receptors differentially mediate impulsive choice in the medial prefrontal and orbitofrontal cortex', Journal of Psychopharmacology, vol. 27, no. 2, pp. 203 - 212, http://dx.doi.org/10.1177/0269881112465497 Zhou C; Douglas JE; Kumar NN; Shu S; Bayliss DA; Chen X, 2013, 'Forebrain HCN1 channels contribute to hypnotic actions of ketamine', Anesthesiology, vol. 118, no. 4, pp. 785 - 795, http://dx.doi.org/10.1097/ALN.0b013e318287b7c8 Parker LM; Kumar NN; Lonergan T; Goodchild AK, 2013, 'Neurochemical codes of sympathetic preganglionic neurons activated by glucoprivation', Journal of Comparative Neurology, vol. 521, no. 12, pp. 2703 - 2718, http://dx.doi.org/10.1002/cne.23310 Turner A; Kumar N; Farnham M; Lung M; Pilowsky P; Mcmullan S, 2013, 'Rostroventrolateral medulla neurons with commissural projections provide input to sympathetic premotor neurons: Anatomical And Functional Evidence', European Journal of Neuroscience, vol. 38, no. 4, pp. 2504 - 2515, http://dx.doi.org/10.1111/ejn.12232 Wang S; Benamer N; Zanella S; Kumar NN; Shi Y; Bévengut M; Penton D; Guyenet PG; Lesage F; Gestreau C; Barhanin J; Bayliss DA, 2013, 'TASK-2 channels contribute to pH sensitivity of retrotrapezoid nucleus chemoreceptor neurons', The Journal of Neuroscience, vol. 33, no. 41, pp. 16033 - 16044, http://dx.doi.org/10.1523/JNEUROSCI.2451-13.2013 Parker LM; Kumar NN; Lonergan T; McMullan S; Goodchild AK, 2013, 'Distribution and neurochemical characterization of neurons in the rat ventrolateral medulla activated by glucoprivation', Brain Structure and Function, vol. 220, no. 1, pp. 117 - 134, http://dx.doi.org/10.1007/s00429-013-0642-3 Parker LM; Tallapragada VJ; Kumar NN; Goodchild AK, 2012, 'Distribution and localisation of Gα proteins in the rostral ventrolateral medulla of normotensive and hypertensive rats: Focus on catecholaminergic neurons', Neuroscience, vol. 218, pp. 20 - 34, http://dx.doi.org/10.1016/j.neuroscience.2012.05.037 Pardey MC; Kumar NN; Goodchild AK; Clemens KJ; Homewood J; Cornish JL, 2012, 'Long-term effects of chronic oral Ritalin administration on cognitive and neural development in adolescent wistar kyoto rats.', Brain Sciences, vol. 2, no. 3, pp. 375 - 404, http://dx.doi.org/10.3390/brainsci2030375 Kumar NN; Allen K; Parker L; Damanhuri H; Goodchild AK, 2010, 'Neuropeptide coding of sympathetic preganglionic neurons; focus on adrenally projecting populations', Neuroscience, vol. 170, no. 3, pp. 789 - 799, http://dx.doi.org/10.1016/j.neuroscience.2010.07.047 Kumar NN; Goodchild AK, 2009, 'Identification and distribution of inositol trisphosphate receptor subtypes in catecholaminergic cell groups in rat brainstem and midbrain', The FASEB Journal, vol. 23, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208621502032&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a Kumar NN; Ferguson J; Padley JR; Pilowsky PM; Goodchild AK, 2009, 'Differential muscarinic receptor gene expression levels in the ventral medulla of spontaneously hypertensive and Wistar - Kyoto rats: Role in sympathetic baroreflex function', Journal of Hypertension, vol. 27, no. 5, pp. 1001 - 1008, http://dx.doi.org/10.1097/HJH.0b013e3283282e5c Padley JR; Kumar NN; Li Q; Nguyen TBV; Pilowsky PM; Goodchild AK, 2007, 'Central command regulation of circulatory function mediated by descending pontine cholinergic inputs to sympathoexcitatory rostral ventrolateral medulla neurons', Circulation Research, vol. 100, no. 2, pp. 284 - 291, http://dx.doi.org/10.1161/01.RES.0000257370.63694.73 Kumar NN; Goodchild AK; Li Q; Pilowsky PM, 2006, 'An aldosterone-related system in the ventrolateral medulla oblongata of spontaneously hypertensive and Wistar-Kyoto rats', Clinical and Experimental Pharmacology and Physiology, vol. 33, no. 1-2, pp. 71 - 75, http://dx.doi.org/10.1111/j.1440-1681.2006.04326.x Speirs HJL; Katyk K; Kumar NN; Benjafield AV; Wang WYS; Morris BJ, 2004, 'Association of G-protein-coupled receptor kinase 4 haplotypes, but not HSD3B1 or PTP1B polymorphisms, with essential hypertension', Journal of Hypertension, vol. 22, no. 5, pp. 931 - 936, http://dx.doi.org/10.1097/00004872-200405000-00014 Kumar NN; Benjafield AV; Lin RCY; Wang WYS; Stowasser M; Morris BJ, 2003, 'Haplotype analysis of aldosterone synthase gene (CYP11B2) polymorphisms shows association with essential hypertension', Journal of Hypertension, vol. 21, no. 7, pp. 1331 - 1337, http://dx.doi.org/10.1097/00004872-200307000-00022