研究领域

Animal Cell and Molecular Biology

Interests are in the fields of muscle biology and cell biology. Particularly interested in aspects of novel structural and cytoskeletal proteins and complexes and their involvement in normal physiology and disease processes. Diseases of interest include muscular dystrophy and other congenital myopathies, diabetes and obesity. Also have an interest in the role of epigenetic events that impact on muscle adaptation to exercise.

近期论文

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Garratt M; Kee AJ; Palme R; Brooks RC, 2016, 'Male Presence can Increase Body Mass and Induce a Stress-Response in Female Mice Independent of Costs of Offspring Production', Scientific Reports, vol. 6, http://dx.doi.org/10.1038/srep23538 Kee AJ; Yang L; Lucas CA; Greenberg MJ; Martel N; Leong GM; Hughes WE; Cooney GJ; James DE; Ostap EM; Han W; Gunning PW; Hardeman EC, 2016, 'Corrigendum to An Actin Filament Population Defined by the Tropomyosin Tpm3.1 Regulates Glucose Uptake [Traic, (2015), 16, 7, 691-711]', Traffic, vol. 17, no. 1, pp. 80 - 81, http://dx.doi.org/10.1111/tra.12342 Schevzov G; Kee AJ; Wang B; Sequeira VB; Hook J; Coombes JD; Lucas CA; Stehn JR; Musgrove EA; Cretu A; Assoian R; Fath T; Hanoch T; Seger R; Pleines I; Kile BT; Hardeman EC; Gunning PW, 2015, 'Regulation of cell proliferation by ERK and signal-dependent nuclear translocation of ERK is dependent on Tm5NM1-containing actin filaments', Molecular Biology of the Cell, vol. 26, no. 13, pp. 2475 - 2490, http://dx.doi.org/10.1091/mbc.E14-10-1453 Kee AJ; Yang L; Lucas CA; Greenberg MJ; Martel N; Leong GM; Hughes WE; Cooney GJ; James DE; Ostap EM; Han W; Gunning PW; Hardeman EC, 2015, 'An Actin Filament Population Defined by the Tropomyosin Tpm3.1 Regulates Glucose Uptake', Traffic, vol. 16, no. 7, pp. 691 - 711, http://dx.doi.org/10.1111/tra.12282 Caldwell BJ; Lucas C; Kee AJ; Gaus K; Gunning PW; Hardeman EC; Yap AS; Gomez GA, 2015, 'Tropomyosin isoforms support actomyosin biogenesis to generate contractile tension at the epithelial zonula adherens', Cytoskeleton, http://dx.doi.org/10.1002/cm.21202 Garratta M; Pichaud N; Glaros EN; Kee AJ; Brooks RC, 2014, 'Superoxide dismutase deficiency impairs olfactory sexual signaling and alters bioenergetic function in mice', Proceedings of the National Academy of Sciences of USA, vol. 111, no. 22, pp. 8119 - 8124, http://dx.doi.org/10.1073/pnas.1322282111 Wang B; Schevzov G; Coombes J; Hook J; Kee A; Lucas C; Stehn J; Sequeira V; Seger R; Hardeman E; Gunning P, 2013, 'Regulation of cell proliferation mediated by the actin filament regulator Tropomyosin 5NM1', Molecular Biology of the Cell, vol. 24, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209348702025&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a Kee AJ; Tran L; Yang L; Genel F; Weigert R; Gunning P; Hardeman E, 2013, 'Identification of a novel Golgi-associated actin filament population that is important for maintaining Golgi morphology', Molecular Biology of the Cell, vol. 24, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209348702023&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a Schevzov G; Kee A; Hook J; Pleines I; Kile B; Hardeman E; Gunning P, 2013, 'Distinct actin filament networks modulate different cell signaling cascades', Molecular Biology of the Cell, vol. 24, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209348702022&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a Lee AS; Anderson JE; Joya JE; Head SI; Pather N; Kee AJ; Gunning PW; Hardeman EC, 2013, 'Aged skeletal muscle retains the ability to fully regenerate functional architecture.', Bioarchitecture, vol. 3, no. 2, pp. 25 - 37, http://dx.doi.org/10.4161/bioa.24966 Lees JG; Ching YW; Adams DH; Bach CTT; Samuel MS; Kee AJ; Hardeman EC; Gunning P; Cowin AJ; O'Neill GM, 2013, 'Tropomyosin regulates cell migration during skin wound healing', Journal of Investigative Dermatology, vol. 133, no. 5, pp. 1330 - 1339, http://dx.doi.org/10.1038/jid.2012.489 Nguyen MAT; Joya JE; Kee AJ; Domazetovska A; Yang N; Hook JW; Lemckert FA; Kettle E; Valova VA; Robinson PJ; North KN; Gunning PW; Mitchell CA; Hardeman EC, 2011, 'Hypertrophy and dietary tyrosine ameliorate the phenotypes of a mouse model of severe nemaline myopathy', Brain: a journal of neurology, vol. 134, no. 12, pp. 3513 - 3526, http://dx.doi.org/10.1093/brain/awr274 Leong GM; Kee AJ; Millard SM; Martel N; Eriksson N; Turner N; Cooney GJ; Hardeman EC; Muscat GEO, 2010, 'The Ski proto-oncogene regulates body composition and suppresses lipogenesis', International Journal of Obesity, vol. 34, no. 3, pp. 524 - 536, http://dx.doi.org/10.1038/ijo.2009.265 Vlahovich N; Kee AJ; Van Der Poel CD; Kettle E; Hernandez-Deviez D; Lucas C; Lynch GS; Parton RG; Gunning PW; Hardeman EC, 2009, 'Cytoskeletal tropomyosin Tm5NM1 is required for normal Excitation- contraction coupling in skeletal muscle', Molecular Biology of the Cell, vol. 20, no. 1, pp. 400 - 409, http://dx.doi.org/10.1091/mbc.E08-06-0616 Kee AJ; Gunning PW; Hardeman EC, 2009, 'Diverse roles of the actin cytoskeleton in striated muscle', Journal of Muscle Research and Cell Motility, vol. 30, no. 5-6, pp. 187 - 197, http://dx.doi.org/10.1007/s10974-009-9193-x Kee AJ; Gunning PW; Hardeman EC, 2009, 'A cytoskeletal tropomyosin can compromise the structural integrity of skeletal muscle', Cell Motility and the Cytoskeleton, vol. 66, no. 9, pp. 710 - 720, http://dx.doi.org/10.1002/cm.20400 Kee AJ; Hardeman EC, 2008, 'Tropomyosins in skeletal muscle diseases', Advances in Experimental Medicine and Biology, vol. 644, pp. 143 - 157, http://dx.doi.org/10.1007/978-0-387-85766-4_12 Cowling BS; McGrath MJ; Nguyen MA; Cottle DL; Kee AJ; Brown S; Schessl J; Zou Y; Joya J; Bönnemann CG; Hardeman EC; Mitchell CA, 2008, 'Identifi cation of FHL1 as a regulator of skeletal muscle mass: Implications for human myopathy', The Journal of Cell Biology, vol. 183, no. 6, pp. 1033 - 1048, http://dx.doi.org/10.1083/jcb.200804077 Macarthur DG; Seto JT; Chan S; Quinlan KGR; Raftery JM; Turner N; Nicholson MD; Kee AJ; Hardeman EC; Gunning PW; Cooney GJ; Head SI; Yang N; North KN, 2008, 'An Actn3 knockout mouse provides mechanistic insights into the association between α-actinin-3 deficiency and human athletic performance', Human Molecular Genetics, vol. 17, no. 8, pp. 1076 - 1086, http://dx.doi.org/10.1093/hmg/ddm380 Chen W; Ruell PA; Ghoddusi M; Kee A; Hardeman EC; Hoffman KM; Thompson MW, 2007, 'Ultrastructural changes and sarcoplasmic reticulum Ca2+ regulation in red vastus muscle following eccentric exercise in the rat', Experimental Physiology, vol. 92, no. 2, pp. 437 - 447, http://dx.doi.org/10.1113/expphysiol.2006.036442