研究领域

Neuroscience, Injury, Pharmacology

The broad research focus of the lab is to examine cellular and molecular mechanisms that may cause or prevent brain cell death resulting from an acute brain injury (ie perinatal asphyxia, stroke, trauma). Drugs with neuroprotective potential are routinely investigated in cell lines, brain tissue cultures and in vivo rat injury models as part of a search for new therapeutic strategies for acute brain injuries. Because tissue hypoxia often occurs after a brain insult, we are interested in learning how hypoxia-inducible proteins (hypoxia-inducible factor-1 (HIF-1), erythropoietin, vascular endothelial growth factor, glucose transporters) are involved in injury and repair processes of the brain.

近期论文

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Chan YL; Saad S; Pollock C; Oliver B; Al-Odat I; Zaky AA; Jones N; Chen H, 2016, 'Impact of maternal cigarette smoke exposure on brain inflammation and oxidative stress in male mice offspring', Scientific Reports, vol. 6, http://dx.doi.org/10.1038/srep25881 Coleman JLJ; Ngo T; Schmidt J; Mrad N; Liew CK; Jones NM; Graham RM; Smith NJ, 2016, 'Metalloprotease cleavage of the N terminus of the orphan G protein-coupled receptor GPR37L1 reduces its constitutive activity', Science Signaling, vol. 9, no. 423, http://dx.doi.org/10.1126/scisignal.aad1089 Lizarme Y; Wangsahardja J; Marcolin GM; Morris JC; Jones NM; Hunter L, 2016, 'Synthesis and neuroprotective activity of dictyoquinazol A and analogues', Bioorganic and Medicinal Chemistry, vol. 24, no. 7, pp. 1480 - 1487, http://dx.doi.org/10.1016/j.bmc.2016.02.016 Chu HX; Jones NM, 2016, 'Changes in Hypoxia-Inducible Factor-1 (HIF-1) and Regulatory Prolyl Hydroxylase (PHD) Enzymes Following Hypoxic–Ischemic Injury in the Neonatal Rat', Neurochemical Research, vol. 41, no. 3, pp. 515 - 522, http://dx.doi.org/10.1007/s11064-015-1641-y Teo JD; Morris MJ; Jones NM, 2015, 'Hypoxic postconditioning reduces microglial activation, astrocyte and caspase activity, and inflammatory markers after hypoxia-ischemia in the neonatal rat brain', Pediatric Research, vol. 77, no. 6, pp. 757 - 764, http://dx.doi.org/10.1038/pr.2015.47 Parmar J; Jones NM, 2015, 'Hypoxic preconditioning can reduce injury-induced inflammatory processes in the neonatal rat brain', International Journal of Developmental Neuroscience, vol. 43, pp. 35 - 42, http://dx.doi.org/10.1016/j.ijdevneu.2015.03.010 Suryana E; Jones NM, 2014, 'The effects of hypoxic preconditioning on white matter damage following hypoxic-ischaemic injury in the neonatal rat brain', International Journal of Developmental Neuroscience, vol. 37, pp. 69 - 75, http://dx.doi.org/10.1016/j.ijdevneu.2014.06.007 Galle AA; Jones NM, 2013, 'The neuroprotective actions of hypoxic preconditioning and postconditioning in a neonatal rat model of hypoxic-ischemic brain injury', Brain Research, vol. 1498, pp. 1 - 8, http://dx.doi.org/10.1016/j.brainres.2012.12.026 Chu PWY; Beart PM; Jones NM, 2010, 'Preconditioning protects against oxidative injury involving hypoxia-inducible factor-1 and vascular endothelial growth factor in cultured astrocytes', European Journal of Pharmacology, vol. 633, no. 1-3, pp. 24 - 32, http://dx.doi.org/10.1016/j.ejphar.2010.02.008 Jones NM; Kardashyan L; Callaway JK; Lee EM; Beart PM, 2008, 'Long-term functional and protective actions of preconditioning with hypoxia, cobalt chloride, and desferrioxamine against hypoxic-ischemic injury in neonatal rats', Pediatric Research, vol. 63, no. 6, pp. 620 - 624, http://dx.doi.org/10.1203/PDR.0b013e31816d9117 Weston RM; Jones NM; Jarrott B; Callaway JK, 2007, 'Inflammatory cell infiltration after endothelin-1-induced cerebral ischemia: Histochemical and myeloperoxidase correlation with temporal changes in brain injury', Journal of Cerebral Blood Flow and Metabolism, vol. 27, no. 1, pp. 100 - 114, http://dx.doi.org/10.1038/sj.jcbfm.9600324 Cimarosti H; O'Shea RD; Jones NM; Horn AP; Simão F; Zamin LL; Nassif M; Frozza R; Netto CA; Beart PM; Salbego C, 2006, 'The effects of estradiol on estrogen receptor and glutamate transporter expression in organotypic hippocampal cultures exposed to oxygen-glucose deprivation', Neurochemical Research, vol. 31, no. 4, pp. 483 - 490, http://dx.doi.org/10.1007/s11064-006-9043-9 O'Shea RD; Lau CL; Farso MC; Diwakarla S; Zagami CJ; Svendsen BB; Feeney SJ; Callaway JK; Jones NM; Pow DV; Danbolt NC; Jarrott B; Beart PM, 2006, 'Effects of lipopolysaccharide on glial phenotype and activity of glutamate transporters: Evidence for delayed up-regulation and redistribution of GLT-1', Neurochemistry International: the journal for the publication of cellular and molecular aspects of neurochemistry, vol. 48, no. 6-7, pp. 604 - 610, http://dx.doi.org/10.1016/j.neuint.2005.12.028 Jones NM; Lee EM; Brown TG; Jarrott B; Beart PM, 2006, 'Hypoxic preconditioning produces differential expression of hypoxia-inducible factor-1α (HIF-1α) and its regulatory enzyme HIF prolyl hydroxylase 2 in neonatal rat brain', Neuroscience Letters, vol. 404, no. 1-2, pp. 72 - 77, http://dx.doi.org/10.1016/j.neulet.2006.05.049 Gresle MM; Jarrott B; Jones NM; Callaway JK, 2006, 'Injury to axons and oligodendrocytes following endothelin-1-induced middle cerebral artery occlusion in conscious rats', Brain Research, vol. 1110, no. 1, pp. 13 - 22, http://dx.doi.org/10.1016/j.brainres.2006.06.111 Cimarosti H; Jones NM; O'Shea RD; Pow DV; Salbego C; Beart PM, 2005, 'Hypoxic preconditioning in neonatal rat brain involves regulation of excitatory amino acid transporter 2 and estrogen receptor alpha', Neuroscience Letters, vol. 385, no. 1, pp. 52 - 57, http://dx.doi.org/10.1016/j.neulet.2005.05.006 Jones NM; Bergeron M, 2004, 'Hypoxia-induced ischemic tolerance in neonatal rat brain involves enhanced ERK1/2 signaling', Journal of Neurochemistry, vol. 89, no. 1, pp. 157 - 167 Jones NM; Bergeron M, 2001, 'Hypoxic preconditioning induces changes in HIF-1 target genes in neonatal rat brain', Journal of Cerebral Blood Flow and Metabolism, vol. 21, no. 9, pp. 1105 - 1114 Bond A; Jones NM; Hicks CA; Whiffin GM; Ward MA; O'Neill MF; Kingston AE; Monn JA; Ornstein PL; Schoepp DD; Lodge D; O'Neill MJ, 2000, 'Neuroprotective Effects of LY379268, a Selective mGlu2/3 Receptor Agonist: Investigations into Possible Mechanism of Action In Vivo', Journal of Pharmacology and Experimental Therapeutics, vol. 294, no. 3, pp. 800 - 809 Mercer LD; Le VQ; Nunan J; Jones NM; Beart PM, 2000, 'Direct visualization of cholecystokinin subtype2 receptors in rat central nervous system using anti-peptide antibodies', Neuroscience Letters, vol. 293, no. 3, pp. 167 - 170, http://dx.doi.org/10.1016/S0304-3940(00)01504-4