研究领域

Neurosciences

Professor Lars Ittner is internationally known for his expertise in developing and analysing new mouse models of human conditions. He has published 69 articles (since commencing his career in 2003), including in top-ranked scientific journals such as Cell, Nature Medicine, Cell Stem Cell, (2x) Nature Reviews Neuroscience, Genes & Development and (3x) PNAS. His work has been cited over 2200 times. He is utilizing and developing latest technologies (such as his own transgenic facility) and combines his medical understanding with his molecular expertise to translate today's discoveries in disease models such as mice, into tomorrows treatments for patients suffering from neurodegenerative conditions. To do this efficiently, he has and will continue to engage with industrial partners for developing and testing novel drugs targeting pathology. Lars Ittner graduated in medicine from the University of Ulm in Germany in 2001, and was awarded with the Doctor of Medicine from the University of Zurich in Switzerland in 2002. In 2002 Lars was selected into the highly competitive Postgraduate (PG) Course for Experimental Biology and Medicine, held at the University of Zurich. After completing the PG course, he became a Postdoctoral Research Fellow in the laboratory of Prof Fischer till June 2005. His work focused on G-protein coupled receptors and neural crest stem cells. In July 2005, he joined Prof Jürgen Götz as a Postdoctoral Research Fellow to establish the Alzheimer’s and Parkinson’s Disease Laboratory at the Brain & Mind Research Institute of the University of Sydney, focusing his work on neurodegenerative disorders. In 2007, Lars became a group leader at the Brain & Mind Research Institute, and was promoted to Senior Lecturer in January 2009. In April 2011, he was promoted to Associate Professor and has led the Alzheimer’s and Parkinson’s Disease Laboratory since early 2012. In July 2013, Lars joined the School of Medical Sciences at the University of New South Wales and Neuroscience Research Australia to head the Dementia Research and Transgenic Animal Units. In January 2014 Lars became a full Professor in the Department of Anatomy at the University of New South Wales.

近期论文

查看导师新发文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Bodea LG; Eckert A; Ittner LM; Piguet O; Götz J, 2016, 'Tau physiology and pathomechanisms in frontotemporal lobar degeneration', Journal of Neurochemistry, http://dx.doi.org/10.1111/jnc.13600 Ahmed RM; Devenney EM; Irish M; Ittner A; Naismith S; Ittner LM; Rohrer JD; Halliday GM; Eisen A; Hodges JR; Kiernan MC, 2016, 'Neuronal network disintegration: Common pathways linking neurodegenerative diseases', Journal of Neurology, Neurosurgery and Psychiatry, http://dx.doi.org/10.1136/jnnp-2014-308350 Chandrakanthan V; Yeola A; Kwan JC; Oliver RA; Qiao Q; Kang YC; Zarzour P; Beck D; Boelen L; Unnikrishnan A; Villanueva JE; Nunez AC; Knezevic K; Palu C; Nasrallah R; Carnell M; Macmillan A; Whan R; Yu Y; Hardy P; Grey ST; Gladbach A; Delerue F; Ittner L; Mobbs R; Walkley CR; Purton LE; Ward RL; Wong JWH; Hesson LB; Walsh W; Pimanda JE, 2016, 'PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells', Proceedings of the National Academy of Sciences of USA, vol. 113, no. 16, pp. E2306 - E2315, http://dx.doi.org/10.1073/pnas.1518244113 Delerue F; Ittner L, 2016, 'A fast, easy and reliable method for the generation of KO mice using CRISPR/Cas9 by a single person: a small laboratory perspective', Transgenic Research, vol. 25, no. 2, pp. 228 - 229, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000371155900079&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a Burrell JR; Halliday GM; Kril JJ; Ittner LM; Götz J; Kiernan MC; Hodges JR, 2016, 'The frontotemporal dementia-motor neuron disease continuum', Lancet, http://dx.doi.org/10.1016/S0140-6736(16)00737-6 Morris GP; Wright AL; Tan RP; Gladbach A; Ittner LM; Vissel B, 2016, 'A comparative study of variables influencing ischemic injury in the longa and koizumi methods of intraluminal filament middle cerebral artery occlusion in mice', PLoS One, vol. 11, no. 2, http://dx.doi.org/10.1371/journal.pone.0148503 Ahmed RM; Irish M; Piguet O; Halliday GM; Ittner LM; Farooqi S; Hodges JR; Kiernan MC, 2016, 'Amyotrophic lateral sclerosis and frontotemporal dementia: Distinct and overlapping changes in eating behaviour and metabolism', Lancet Neurology, http://dx.doi.org/10.1016/S1474-4422(15)00380-4 Leshchyns'Ka I; Liew HT; Shepherd C; Halliday GM; Stevens CH; Ke YD; Ittner LM; Sytnyk V, 2015, 'Aβ-dependent reduction of NCAM2-mediated synaptic adhesion contributes to synapse loss in Alzheimer's disease', Nature Communications, vol. 6, http://dx.doi.org/10.1038/ncomms9836 Narlawar R; Werry EL; Scarf AM; Hanani R; Chua SW; King VA; Barron ML; Martins RN; Ittner LM; Rendina LM; Kassiou M, 2015, 'First demonstration of positive allosteric-like modulation at the human wild type translocator protein (TSPO)', Journal of Medicinal Chemistry, vol. 58, no. 21, pp. 8743 - 8749, http://dx.doi.org/10.1021/acs.jmedchem.5b01288 van Eersel J; Stevens CH; Przybyla M; Gladbach A; Stefanoska K; Chan CKX; Ong WY; Hodges JR; Sutherland GT; Kril JJ; Abramowski D; Staufenbiel M; Halliday GM; Ittner LM, 2015, 'Early-onset axonal pathology in a novel P301S-Tau transgenic mouse model of frontotemporal lobar degeneration', Neuropathology and Applied Neurobiology, vol. 41, no. 7, pp. 906 - 925, http://dx.doi.org/10.1111/nan.12233 Brettle M; Suchowerska AK; Chua SW; Ittner LM; Fath T, 2015, 'Amyotrophic lateral sclerosis-associated mutant profilin 1 increases dendritic arborisation and spine formation in primary hippocampal neurons', Neuroscience Letters, vol. 609, pp. 223 - 228, http://dx.doi.org/10.1016/j.neulet.2015.09.034 Ke YD; van Hummel A; Stevens CH; Gladbach A; Ippati S; Bi M; Lee WS; Krüger S; van der Hoven J; Volkerling A; Bongers A; Halliday G; Haass NK; Kiernan M; Delerue F; Ittner LM, 2015, 'Short-term suppression of A315T mutant human TDP-43 expression improves functional deficits in a novel inducible transgenic mouse model of FTLD-TDP and ALS', Acta Neuropathologica, vol. 130, no. 5, pp. 661 - 678, http://dx.doi.org/10.1007/s00401-015-1486-0 Verdile G; Asih PR; Barron AM; Wahjoepramono EJ; Ittner LM; Martins RN, 2015, 'The impact of luteinizing hormone and testosterone on beta amyloid (Aβ) accumulation: Animal and human clinical studies', Hormones and Behaviour, http://dx.doi.org/10.1016/j.yhbeh.2015.05.020 Ittner LM; Halliday GM; Kril JJ; Götz J; Hodges JR; Kiernan MC, 2015, 'FTD and ALS—translating mouse studies into clinical trials', Nature Reviews Neurology, http://dx.doi.org/10.1038/nrneurol.2015.65 Purushothuman S; Johnstone DM; Nandasena C; van Eersel J; Ittner LM; Mitrofanis J; Stone J, 2015, 'Near infrared light mitigates cerebellar pathology in transgenic mouse models of dementia', Neuroscience Letters, vol. 591, pp. 155 - 159, http://dx.doi.org/10.1016/j.neulet.2015.02.037 Ittner A; Bertz J; Suh LS; Stevens CH; Götz J; Ittner LM, 2015, 'Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice', Journal of Neurochemistry, vol. 132, no. 1, pp. 135 - 145, http://dx.doi.org/10.1111/jnc.12821 Ittner AA; Gladbach A; Bertz J; Suh LS; Ittner LM, 2014, 'p38 MAP kinase-mediated NMDA receptor-dependent suppression of hippocampal hypersynchronicity in a mouse model of Alzheimer's disease', Acta Neuropathologica Communications, vol. 2, pp. 149, http://dx.doi.org/10.1186/s40478-014-0149-z Nisbet RM; Polanco J-C; Ittner LM; Götz J, 2014, 'Tau aggregation and its interplay with amyloid-β', Acta Neuropathologica, http://dx.doi.org/10.1007/s00401-014-1371-2 Ittner AA; Bertz J; van Eersel J; Polly P; Ittner LM; Chan TYB, 2014, 'The nucleotide exchange factor SIL1 is required for glucose-stimulated insulin secretion from mouse pancreatic beta cells in vivo', Diabetologia, http://dx.doi.org/10.1007/s00125-014-3230-z Chua SW; Kassiou M; Ittner LM, 2014, 'The translocator protein as a drug target in Alzheimer's disease', Expert Review of Neurotherapeutics: a key contribution to decision making in the treatment of neurologic and neuropsychiatric disorders, vol. 14, no. 4, pp. 439 - 448, http://dx.doi.org/10.1586/14737175.2014.896201