研究领域

Humoral Immunology and Immunochemistry

My research interests focus on mast cell biology and the discovery and molecular characterisation of novel mast cell proteases. We have recently discovered a number of novel human mast cell tryptases, and we are currently determining their substrate specificity. Another aspect of our work involves the characterisation of factors that control the biology of mast cells. We have demonstrated that IL-15 is one of the most potent mast cell attractants yet reported, and also acts to upregulate the expression of ubiquitin-protein ligase 3B, matrix metalloproteinase 9 (MMP9) and apolipoprotein CI (ApoC1) by mast cells.

近期论文

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Yang Ai SS; Hsu K; Herbert C; Cheng Z; Hunt J; Lewis CR; Thomas PS, 2013, 'Mitochondrial DNA mutations in exhaled breath condensate of patients with lung cancer', Respiratory Medicine, vol. 107, no. 6, pp. 911 - 918, http://dx.doi.org/10.1016/j.rmed.2013.02.007 Yang Ai SS; Hsu K; Herbert C; Cheng Z; Hunt J; Lewis CR; Thomas PS, 2013, 'Response to "MtDNA depletions and deletions may also important in pathogenesis of lung cancer"', Respiratory Medicine, http://dx.doi.org/10.1016/j.rmed.2013.08.017 Hunt JE; Scicluna H; McNeil HP, 2011, 'Development and evaluation of a mandatory research experience in an undergraduate medical education program: the independent learning project at UNSW.', The journal of the International Association of Medical Science Educators : JIAMSE, vol. 21(1S), pp. 78 - 85, http://www.iamse.org/artman/publish/cat_index_94.shtml Jackson NE; Wang H-W; Bryant KJ; McNeil HP; Husain A; Liu K; Tedla N; Thomas PS; King GC; Hettiaratchi A; Cairns J; Hunt JE, 2008, 'Alternate mRNA Splicing in Multiple Human Tryptase Genes Is Predicted to Regulate Tetramer Formation', Journal of Biological Chemistry, vol. 283, no. 49, pp. 34178 - 34187, http://dx.doi.org/10.1074/jbc.M807553200 Huynh OA; Hampartzoumian T; Arm JP; Hunt J; Borges L; Ahern M; Smith M; Geczy CL; McNeil HP; Tedla N, 2007, 'Down-regulation of leucocyte immunoglobulin-like receptor expression in the synovium of rheumatoid arthritis patients after treatment with disease-modifying anti-rheumatic drugs', Rheumatology, vol. 46, no. 5, pp. 742 - 751, http://dx.doi.org/10.1093/rheumatology/kel405 Yang Z; Yan WX; Cai H; Tedla N; Armishaw C; Di Girolamo N; Wang HW; Hampartzoumian T; Simpson JL; Gibson PG; Hunt J; Hart P; Hughes JM; Perry MA; Alewood PF; Geczy CL, 2007, 'S100A12 provokes mast cell activation: A potential amplification pathway in asthma and innate immunity', Journal of Allergy and Clinical Immunology, vol. 119, no. 1, pp. 106 - 114, http://dx.doi.org/10.1016/j.jaci.2006.08.021 Hettiaratchi A; Hawkins NJ; McKenzie G; Ward RL; Hunt JE; Wakefield D; Di Girolamo N, 2007, 'The collagenase-1 (MMP-1) gene promoter polymorphism - 1607/2G is associated with favourable prognosis in patients with colorectal cancer', British Journal of Cancer, vol. 96, no. 5, pp. 783 - 792, http://dx.doi.org/10.1038/sj.bjc.6603630 Geczy CL; Yang Z; Yan W-X; Cai H; Tedla N; Perry M; Hunt J; Hart P, 2005, 'S100A12 and mast cell activation in inflammation', Inflammation Research, vol. 54, pp. S129 - S129, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000205501600134&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a Wei XM; Kim HS; Kumar RK; Heywood GJ; Hunt JE; McNeil HP; Thomas PS, 2005, 'Effects of cigarette smoke on degranulation and NO production by mast cells and epithelial cells', Respiratory Research, vol. 6, http://dx.doi.org/10.1186/1465-9921-6-108 Jackson NE; Wang H-W; Tedla N; McNeil HP; Geczy CL; Collins A; Grimm MC; Hampartzoumian T; Hunt JE, 2005, 'IL-15 induces mast cell migration via a pertussis toxin-sensitive receptor', European Journal of Immunology, vol. 35, no. 8, pp. 2376 - 2385, http://dx.doi.org/10.1002/eji.200526154 Wang H-W; Tedla N; Hunt JE; Wakefield D; McNeil HP, 2005, 'Mast cell accumulation and cytokine expression in the tight skin mouse model of scleroderma', Experimental Dermatology, vol. 14, no. 4, pp. 295 - 302, http://dx.doi.org/10.1111/j.0906-6705.2005.00315.x Li M; Liu K; Michalicek J; Angus JA; Hunt JE; Dell'Italia LJ; Feneley MP; Graham RM; Husain A, 2004, 'Involvement of chymase-mediated angiotensin II generation in blood pressure regulation.', Journal of Clinical Investigation, vol. 114, no. 1, pp. 112 - 120, http://dx.doi.org/10.1172/JCI20805 Wang HW; McNeil HP; Husain A; Liu K; Tedla N; Thomas PS; Raftery M; King GC; Cai ZY; Hunt JE, 2002, 'Delta tryptase is expressed in multiple human tissues, and a recombinant form has proteolytic activity.', Journal of Immunology, vol. 169, no. 9, pp. 5145 - 5152, http://www.ncbi.nlm.nih.gov/pubmed/12391231 Friend DS; Gurish MF; Austen KF; Hunt J; Stevens RL, 2000, 'Senescent jejunal mast cells and eosinophils in the mouse preferentially translocate to the spleen and draining lymph node, respectively, during the recovery phase of helminth infection.', Journal of Immunology, vol. 165, no. 1, pp. 344 - 352, http://www.ncbi.nlm.nih.gov/pubmed/10861071 Huang C, 1999, 'Human Tryptases alpha and beta /II Are Functionally Distinct Due, in Part, to a Single Amino Acid Difference in One of the Surface Loops That Forms the Substrate-binding Cleft', Journal of Biological Chemistry, vol. 274, no. 28, pp. 19670 - 19676, http://dx.doi.org/10.1074/jbc.274.28.19670 Friend DS; Ghildyal N; Gurish MF; Hunt J; Hu XZ; Austen KF; Stevens RL, 1998, 'Reversible expression of tryptases and chymases in the jejunal mast cells of mice infected with Trichinella spiralis', Journal of Immunology, vol. 160, no. 11, pp. 5537 - 5545, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000073735400045&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a Huang C; Friend DS; Qiu WT; Wong GW; Morales G; Hunt J; Stevens RL, 1998, 'Induction of a selective and persistent extravasation of neutrophils into the peritoneal cavity by tryptase mouse mast cell protease 6.', Journal of Immunology, vol. 160, no. 4, pp. 1910 - 1919, http://www.ncbi.nlm.nih.gov/pubmed/9469453 Hunt JE; Friend DS; Gurish MF; Feyfant E; Sali A; Huang C; Ghildyal N; Stechschulte S; Austen KF; Stevens RL, 1997, 'Mouse Mast Cell Protease 9, a Novel Member of the Chromosome 14 Family of Serine Proteases that is Selectively Expressed in Uterine Mast Cells', Journal of Biological Chemistry, vol. 272, no. 46, pp. 29158 - 29166, http://dx.doi.org/10.1074/jbc.272.46.29158 Hunt JE; Stevens RL; Austen KF; Zhang J; Xia Z; Ghildyal N, 1996, 'Natural Disruption of the Mouse Mast Cell Protease 7 Gene in the C57BL/6 Mouse', Journal of Biological Chemistry, vol. 271, no. 5, pp. 2851 - 2855, http://dx.doi.org/10.1074/jbc.271.5.2851 Murakami M, 1996, 'A Heparin-sensitive Phospholipase A2 and Prostaglandin Endoperoxide Synthase-2 Are Functionally Linked in the Delayed Phase of Prostaglandin D2 Generation in Mouse Bone Marrow-derived Mast Cells', Journal of Biological Chemistry, vol. 271, no. 42, pp. 25936 - 25944, http://dx.doi.org/10.1074/jbc.271.42.25936