研究领域

Neurology and Neuromuscular Diseases

Gary Housley, PhD, holds the Chair of Physiology and is director of the Translational Neuroscience Facility, School of Medical Sciences, UNSW Australia. His research program is broadly within molecular, cellular and systems physiology in the nervous system, particularly around neuroprotection in the CNS and auditory system. He has contributed prominently to understanding how hearing adapts to noise and ageing. Study of neural development and synaptic plasticity in the auditory system informs on gene-targets for neural repair. This research has an applied arm with respect to bionics such as the cochlear implant which has led to development of an innovative gene therapy platform for auditory nerve regeneration. Within the brain, Housley's research group are investigating neural plasticity associated with driven input ( e.g. via the cochlear implant) and mechanisms for protection and repair of the nervous system (focusing of the role of calcium siganalling in glutamate excitotoxicity, associated with ischaemic brain injury, stroke, epilepsy and trauma, alongside noise-induced hearing loss. Hearing loss is the most prominent sensory disability in our society. Stroke is the third highest killer and the most disabling for survivors. The research is supported by national and international collaborations and funding.

近期论文

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Przybyla M; Stevens CH; van der Hoven J; Harasta A; Bi M; Ittner A; van Hummel A; Hodges JR; Piguet O; Karl T; Kassiou M; Housley GD; Ke YD; Ittner LM; Eersel JV, 2016, 'Disinhibition-like behavior in a P301S mutant tau transgenic mouse model of frontotemporal dementia', Neuroscience Letters, vol. 631, pp. 24 - 29, http://dx.doi.org/10.1016/j.neulet.2016.08.007 Housley GD, 2016, 'Keeping the noise down', Australasian Science, no. April 2016, pp. 36 - 38 Craig AJ; Housley GD, 2016, 'Evaluation of gene therapy as an intervention strategy to treat brain injury from stroke', Frontiers in Molecular Neuroscience, vol. 9, no. MAY, http://dx.doi.org/10.3389/fnmol.2016.00034 von Jonquieres G; Froehlich D; Klugmann CB; Wen X; Harasta AE; Ramkumar R; Spencer ZHT; Housley GD; Klugmann M, 2016, 'Recombinant Human Myelin-Associated Glycoprotein Promoter Drives Selective AAV-Mediated Transgene Expression in Oligodendrocytes', Frontiers in Molecular Neuroscience, vol. 9, http://dx.doi.org/10.3389/fnmol.2010.00013 Browne CJ; Pinyon JL; Housley DM; Crawford EN; Lovell NH; Klugmann M; Housley GD, 2016, 'Mapping of bionic array electric field focusing in plasmid DNA-based gene electrotransfer', Gene Therapy (Basingstoke), vol. 23, no. 4, pp. 369 - 379, http://dx.doi.org/10.1038/gt.2016.8 Morton-Jones RT; Vlajkovic SM; Thorne PR; Cockayne DA; Ryan AF; Housley GD, 2015, 'Properties of ATP-gated ion channels assembled from P2X2 subunits in mouse cochlear Reissner’s membrane epithelial cells', Purinergic Signalling, vol. 11, no. 4, pp. 551 - 560, http://dx.doi.org/10.1007/s11302-015-9473-4 Harasta AE; Power JM; Von Jonquieres G; Karl T; Drucker DJ; Housley GD; Schneider M; Klugmann M, 2015, 'Septal glucagon-like peptide 1 receptor expression determines suppression of cocaine-induced behavior', Neuropsychopharmacology, vol. 40, no. 8, pp. 1969 - 1978, http://dx.doi.org/10.1038/npp.2015.47 Froud KE; Wong ACY; Cederholm JME; Klugmann M; Sandow SL; Julien JP; Ryan AF; Housley GD, 2015, 'Type II spiral ganglion afferent neurons drive medial olivocochlear reflex suppression of the cochlear amplifier', Nature Communications, vol. 6, http://dx.doi.org/10.1038/ncomms8115 Canales CP; Wong ACY; Gunning PW; Housley GD; Hardeman EC; Palmer SJ, 2015, 'The role of GTF2IRD1 in the auditory pathology of Williams–Beuren Syndrome', European Journal of Human Genetics, vol. 23, no. 6, pp. 774 - 780, http://dx.doi.org/10.1038/ejhg.2014.188 Vlajkovic SM; Chang H; Paek SY; Chi HHT; Sreebhavan S; Telang RS; Tingle M; Housley GD; Thorne PR, 2014, 'Adenosine Amine Congener as a Cochlear Rescue Agent', BioMed Research International, vol. 2014, http://dx.doi.org/10.1155/2014/841489 Housley GD; Cederholm JME; Klugmann M; Ryan AF, 2014, 'Purinergic signaling in the cochlea', Purinergic Signalling, vol. 10, no. 4, pp. 726 - 727, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000348578700187&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a Von Jonquieres G; Froud KE; Klugmann CB; Wong ACY; Housley GD; Klugmann M, 2014, 'Loss of central auditory processing in a mouse model of canavan disease', PLoS One, vol. 9, no. 5, http://dx.doi.org/10.1371/journal.pone.0097374 Pinyon JL; Tadros SF; Froud KE; Wong ACY; Tompson IT; Crawford EN; Ko M; Morris R; Klugmann M; Housley GD, 2014, 'Close-field electroporation gene delivery using the cochlear implant electrode array enhances the bionic ear', Science Translational Medicine, vol. 6, no. 233, http://dx.doi.org/10.1126/scitranslmed.3008177 Jonquieres G; Mersmann N; Teahan O; Klugmann CB; Harasta AE; Lutz B; Housley GD; Klugmann M, 2013, 'AAV-BASED GENE THERAPY APPROACHES FOR THE TREATMENT OF CANAVAN DISEASE', Cytotherapy, vol. 15, no. 4, pp. S12 - S12, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000316535700029&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a Brand Y; Sung M; Chavez E; Wei E; Pak KK; Housley GD; Bodmer D; Ryan AF, 2013, 'Neural cell adhesion molecule L1 modulates type i but not type II inner ear spiral ganglion neurite outgrowth in an in vitro alternate choice assay', Journal of Molecular Neuroscience, vol. 51, no. 3, pp. 663 - 670, http://dx.doi.org/10.1007/s12031-013-0040-6 von Jonquieres G; Mersmann N; Klugmann CB; Harasta AE; Lutz B; Teahan O; da Housley G; Fröhlich D; Krämer-Albers EM; Klugmann M, 2013, 'Glial Promoter Selectivity following AAV-Delivery to the Immature Brain', PLoS One, vol. 8, no. 6, http://dx.doi.org/10.1371/journal.pone.0065646 Housley GD; Morton-Jones R; Vlajkovic SM; Telang RS; Paramananthasivam V; Tadros SF; Wong AY; Froud KE; Cederholm JME; Sivakumaran Y; Snguanwongchai P; Khakh BS; Cockayne DA; Thorne PR; Ryan AF, 2013, 'ATP-gated ion channels mediate adaptation to elevated sound levels', Proceedings of the National Academy of Sciences of USA, vol. 110, no. 18, pp. 7494 - 7499, http://dx.doi.org/10.1073/pnas.1222295110 Wong ACY; Birnbaumer L; Housley GD, 2013, 'Canonical transient receptor potential channel subtype 3-mediated hair cell Ca2+ entry regulates sound transduction and auditory neurotransmission', European Journal of Neuroscience, vol. 37, no. 9, pp. 1478 - 1486, http://dx.doi.org/10.1111/ejn.12158 Yan D; Zhu Y; Walsh T; Xie D; Yuan H; Sirmaci A; Fujikawa T; Wong ACY; Loh TL; Du L; Grati M; Vlajkovic SM; Blanton S; Ryan AF; Chen ZY; Thorne PR; Kachar B; Tekin M; Zhao HB; Housley GD; King MC; Liu XZ, 2013, 'Mutation of the ATP-gated P2X2 receptor leads to progressive hearing loss and increased susceptibility to noise', Proceedings of the National Academy of Sciences of USA, vol. 110, no. 6, pp. 2228 - 2233, http://dx.doi.org/10.1073/pnas.1222285110 Cederholm JME; Froud KE; Wong ACY; Ko M; Ryan AF; Housley GD, 2012, 'Differential actions of isoflurane and ketamine-based anaesthetics on cochlear function in the mouse', Hearing Research, vol. 292, no. 1-2, pp. 71 - 79, http://dx.doi.org/10.1016/j.heares.2012.08.010