研究领域

Pathology, Pulmonary Disease, Allergy, Inflammation

My primary research focus is on the pathogenesis of asthma. Currently I am investigating the mechanisms by which exposure to environmental pollutants during early life contributes to the development of childhood asthma, as well as the mechanisms underlying severe airway inflammation in acute exacerbations of asthma. Additional interests include the identification and evaluation of anti-inflammatory agents, including novel drugs and natural products, using cell culture systems and clinically relevant models of asthma in mice. I am also extensively involved in undergraduate teaching, in research training for both Medicine and Science undergraduate students in the School of Medical Sciences, and in postgraduate research training in the Faculty of Medicine at UNSW.

近期论文

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Xiang Y; Eyers F; Herbert C; Tay HL; Foster PS; Yang M, 2016, 'MicroRNA-487b is a negative regulator of macrophage activation by targeting IL-33 production', Journal of Immunology, vol. 196, no. 8, pp. 3421 - 3428, http://dx.doi.org/10.4049/jimmunol.1502081 Zhou H; Zhang J; Eyers F; Xiang Y; Herbert C; Tay HL; Foster PS; Yang M, 2016, 'Identification of the microRNA networks contributing to macrophage differentiation and function', Oncotarget, vol. 7, no. 20, pp. 28806 - 28820, http://dx.doi.org/10.18632/oncotarget.8933 Mohan N; Akter R; Bryant K; Herbert C; Chow S; Thomas PS, 2016, 'Exhaled breath markers of alveolar macrophage activity in sarcoidosis', Inflammation Research, vol. 65, no. 6, pp. 471 - 478, http://dx.doi.org/10.1007/s00011-016-0929-y Kumar RK; Herbert C; Foster PS, 2016, 'Mouse models of acute exacerbations of allergic asthma', Respirology, http://dx.doi.org/10.1111/resp.12760 Herbert C; Bunting MM; Lambie N; Thomas PS; Kumar RK, 2015, 'Immunoreactivity for interleukin-33 in allergic airway inflammation', Journal of Cytology and Histology, http://dx.doi.org/10.4172/2157-7099.1000302 Herbert C; Sebesfi M; Zeng QX; Oliver BG; Foster PS; Kumar RK, 2015, 'Using multiple online databases to help identify microRNAs regulating the airway epithelial cell response to a virus-like stimulus', Respirology, vol. 20, no. 8, pp. 1206 - 1212, http://dx.doi.org/10.1111/resp.12606 Loke WSJ; Freeman A; Garthwaite L; Prazakova S; Park M; Hsu K; Thomas PS; Herbert C, 2015, 'T-bet and interleukin-27: possible TH1 immunomodulators of sarcoidosis', Inflammopharmacology: experimental and clinical studies, vol. 23, no. 5, pp. 283 - 290, http://dx.doi.org/10.1007/s10787-015-0247-y Hiroshima Y; Garthwaite L; Hsu K; Yoo H; Park SH; Geczy CL; Kumar RK; Herbert C, 2015, 'ISU201 enhances the resolution of airway inflammation in a mouse model of an acute exacerbation of asthma', Mediators of Inflammation, vol. 2015, http://dx.doi.org/10.1155/2015/405629 Amin T; Herbert C; Thomas P, 2015, 'The Immune Paradox of Sarcoidosis: A Review of Literature', British Journal of Medicine and Medical Research, vol. 5, no. 6, pp. 734 - 748, http://dx.doi.org/10.9734/BJMMR/2015/12473 Kumar RK; Herbert C, 2015, 'IL-33-dependent type 2 inflammation in asthma exacerbations', American Journal of Respiratory and Critical Care Medicine, vol. 191, no. 2, pp. 237 - 238 Tang SN; Thomas PS; Herbert C, 2014, 'Immunopathogenesis and the use of Exhaled Breath Condensate Analysis in Sarcoidosis.', Journal of Applied Medical Sciences Kumar RK; Shadie AM; Bucknall MP; Rutlidge H; Garthwaite L; Herbert C; Halliburton B; Parsons KS; Wark PA, 2014, 'Differential injurious effects of ambient and traffic-derived particulate matter on airway epithelial cells', Respirology, http://dx.doi.org/10.1111/resp.12381 Ringkowski S; Thomas PS; Herbert C, 2014, 'Interleukin-12 family cytokines and sarcoidosis', Frontiers in Pharmacology, vol. 5, no. OCT, http://dx.doi.org/10.3389/fphar.2014.00233 Eiffe E; Pasquier E; Kavallaris M; Herbert C; Black DSC; Kumar N, 2014, 'Synthesis, anti-cancer and anti-inflammatory activity of novel 2-substituted isoflavenes', Bioorganic and Medicinal Chemistry, vol. 22, no. 19, pp. 5182 - 5193, http://dx.doi.org/10.1016/j.bmc.2014.08.010 Herbert C; Zeng QX; Shanmugasundaram R; Garthwaite L; Oliver BG; Kumar RK, 2014, 'Response of airway epithelial cells to double-stranded RNA in an allergic environment.', Advances in Integrative Omics and Applied Biotechnology, vol. 2, no. 1, pp. 11, http://dx.doi.org/10.1186/s40247-014-0011-6 Shadie AM; Herbert C; Kumar RK, 2014, 'Ambient particulate matter induces an exacerbation of airway inflammation in experimental asthma: Role of interleukin-33', Clinical and Experimental Immunology, vol. 177, no. 2, pp. 491 - 499, http://dx.doi.org/10.1111/cei.12348 Hiroshima Y; Hsu K; Tedla N; Chung YM; Chow S; Herbert C; Geczy CL, 2014, 'S100A8 induces IL-10 and protects against acute lung injury', Journal of Immunology, vol. 192, no. 6, pp. 2800 - 2811, http://dx.doi.org/10.4049/jimmunol.1302556 Herbert C; Shadie AM; Bunting MM; Tedla N; Garthwaite L; Freeman A; Yoo H; Park SH; Kumar RK, 2014, 'Anti-inflammatory and anti-remodelling effects of ISU201, a modified form of the extracellular domain of human BST2, in experimental models of asthma: Association with inhibition of histone acetylatio', PLoS One, vol. 9, no. 3, http://dx.doi.org/10.1371/journal.pone.0090436 Flesher RP; Herbert C; Kumar RK, 2014, 'Resolvin E1 promotes resolution of inflammation in a mouse model of an acute exacerbation of allergic asthma', Clinical Science, vol. 126, no. 11, pp. 805 - 814, http://dx.doi.org/10.1042/CS20130623 Loke WSJ; Herbert C; Thomas PS, 2013, 'Sarcoidosis: Immunopathogenesis and Immunological Markers', International Journal of Chronic Diseases, vol. 2013, pp. 1 - 13, http://dx.doi.org/10.1155/2013/928601