研究领域

Oncology and Carcinogenesis

Over his career to date, Prof Hawkins has pursued research interests in the molecular basis of colorectal carcinogenesis. His research interests draw on his professional expertise in anatomical pathology and his research training in molecular and cellular biology, and focus on the correlation of histopathological features of colorectal neoplasia to the molecular characteristics of the disease. In this work, a key achievement has been the accumulation and documentation of a large series of colorectal cancer tissues (>1500) that serves as the basis for the ongoing work of the research group. Using this tissue resource, he has been able to clearly demonstrate the critical role of serrated as precursor lesions in microsatellite unstable colorectal cancers. More recently, he and his colleagues have been at the forefront of descriptions of the phenomenon of CpG island methylation in colorectal cancer, and its biological significance. He has over ninety publications in international peer reviewed journals, including first author publications in highest ranking journals in the fields of gastroenterology, pathology and cancer research. His work has been cited over 3000 times by other scientists (H factor 27). Over the last decade, his work has been continuously funded by peer reviewed organisations as well as commercial funding, and eight students have attained higher degree awards under his supervision. In the broader area of bowel cancer research, he has successfully and repeatedly translated findings from basic research to the real world of current clinical practice.

近期论文

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Ma SSQ; Srivastava S; Llamosas E; Hawkins NJ; Hesson LB; Ward RL; Ford CE, 2016, 'ROR2 is epigenetically inactivated in the early stages of colorectal neoplasia and is associated with proliferation and migration', BMC Cancer, vol. 16, no. 1, http://dx.doi.org/10.1186/s12885-016-2576-7 Polly P; Velan GM; Hawkins N, 2015, 'Development of Online Science Practical Lesson Resources to Enhance Student Learning in Phases 1 and 2 Medicine at UNSW Australia.', Proceedings of E-Learn: World Conference on E-Learning in Corporate, Government, Healthcare, and Higher Education 2015, pp. 1452 - 1458, http://www.editlib.org/pv/152202/ Jorissen RN; Christie M; Mouradov D; Sakthianandeswaren A; Li S; Love C; Xu ZZ; Molloy PL; Jones IT; McLaughlin S; Ward RL; Hawkins NJ; Ruszkiewicz AR; Moore J; Burgess AW; Busam D; Zhao Q; Strausberg RL; Lipton L; Desai J; Gibbs P; Sieber OM, 2015, 'Wild-type APC predicts poor prognosis in microsatellite-stable proximal colon cancer', British Journal of Cancer, vol. 113, no. 6, pp. 979 - 988, http://dx.doi.org/10.1038/bjc.2015.296 Wong V; Smith AJ; Hawkins NJ; Kumar RK; Young N; Kyaw M; Velan GM, 2015, 'Adaptive Tutorials Versus Web-Based Resources in Radiology: A Mixed Methods Comparison of Efficacy and Student Engagement', Academic Radiology, http://dx.doi.org/10.1016/j.acra.2015.07.002 Scott GM; Hettiaratchi A; Salisbury E; Ward RL; Hawkins NJ, 2015, 'Institutional biobanking: An integral part of contemporary pathology practice', Pathology, vol. 47, no. 1, pp. 4 - 6, http://dx.doi.org/10.1097/PAT.0000000000000185 Zarzour P; Boelen L; Luciani F; Beck D; Sakthianandeswaren A; Mouradov D; Sieber OM; Hawkins NJ; Hesson LB; Ward RL; Wong JWH, 2015, 'Single nucleotide polymorphism array profiling identifies distinct chromosomal aberration patterns across colorectal adenomas and carcinomas', Genes Chromosomes and Cancer, vol. 54, no. 5, pp. 303 - 314, http://dx.doi.org/10.1002/gcc.22243 Yang J-L; Coleman K; Das M; Hawkins NJ, 2015, 'Integrated Career Development Learning and ePortfolios: Improving Student Self-efficacy in Employability Skills in an Undergraduate Science Course', International Journal of Adult, Community and Professional Learning, vol. 22, no. 1, pp. 1 - 17, http://jialinyang.cgpublisher.com/product/pub.255/prod.57 Hesson LB; Sloane MA; Wong JWH; Nunez AC; Srivastava S; Ng B; Hawkins NJ; Bourke MJ; Ward RL, 2014, 'Altered promoter nucleosome positioning is an early event in gene silencing', Epigenetics, vol. 9, no. 10, pp. 1422 - 1430, http://dx.doi.org/10.4161/15592294.2014.970077 Henry C; Quadir A; Hawkins NJ; Jary E; Llamosas E; Kumar D; Daniels B; Ward RL; Ford CE, 2014, 'Expression of the novel Wnt receptor ROR2 is increased in breast cancer and may regulate both β-catenin dependent and independent Wnt signalling', Journal of Cancer Research and Clinical Oncology, vol. 141, no. 2, pp. 243 - 254, http://dx.doi.org/10.1007/s00432-014-1824-y Xu H; Yan Y; Deb S; Rangasamy D; Germann M; Malaterre J; Eder NC; Ward RL; Hawkins NJ; Tothill RW; Chen L; Mortensen NJ; Fox SB; McKay MJ; Ramsay RG, 2014, 'Cohesin Rad21 Mediates Loss of Heterozygosity and Is Upregulated via Wnt Promoting Transcriptional Dysregulation in Gastrointestinal Tumors', Cell Reports, vol. 9, no. 5, pp. 1781 - 1789, http://dx.doi.org/10.1016/j.celrep.2014.10.059 Sloane MA; Wong JWH; Perera D; Nunez AC; Pimanda JE; Hawkins NJ; Sieber OM; Bourke MJ; Hesson LB; Ward RL, 2014, 'Epigenetic inactivation of the candidate tumor suppressor USP44 is a frequent and early event in colorectal neoplasia', Epigenetics, vol. 9, no. 8, pp. 1092 - 1100, http://dx.doi.org/10.4161/epi.29222 Wyld L; Smith S; Hawkins NJ; Long J; Ward RL, 2014, 'Introducing research initiatives into healthcare: What do doctors think?', Biopreservation and Biobanking, vol. 12, no. 2, pp. 91 - 98, http://dx.doi.org/10.1089/bio.2013.0069 Dewhurst SM; McGranahan N; Burrell RA; Rowan AJ; Grönroos E; Endesfelder D; Joshi T; Mouradov D; Gibbs P; Ward RL; Hawkins NJ; Szallasi Z; Sieber OM; Swanton C, 2014, 'Tolerance of whole- genome doubling propagates chromosomal instability and accelerates cancer genome evolution', Cancer Discovery, vol. 4, no. 2, pp. 175 - 185, http://dx.doi.org/10.1158/2159-8290.CD-13-0285 Deb S; Xu H; Tuynman J; George J; Yan Y; Li J; Ward RL; Mortensen N; Hawkins NJ; McKay MJ; Ramsay RG; Fox SB, 2014, 'RAD21 cohesin overexpression is a prognostic and predictive marker exacerbating poor prognosis in KRAS mutant colorectal carcinomas', British Journal of Cancer, vol. 110, no. 6, pp. 1606 - 1613, http://dx.doi.org/10.1038/bjc.2014.31 Webster LR; Provan PJ; Graham DJ; Byth K; Walker RL; Davis S; Salisbury EL; Morey AL; Ward RL; Hawkins NJ; Clarke CL; Meltzer PS; Balleine RL, 2013, 'Prohibitin expression is associated with high grade breast cancer but is not a driver of amplification at 17q21.33', Pathology, vol. 45, no. 7, pp. 629 - 636, http://dx.doi.org/10.1097/PAT.0000000000000004 Fleming NI; Jorissen RN; Mouradov D; Christie M; Sakthianandeswaren A; Palmieri M; Day F; Li S; Tsui C; Lipton L; Desai J; Jones IT; McLaughlin S; Ward RL; Hawkins NJ; Ruszkiewicz AR; Moore J; Zhu H-J; Mariadason JM; Burgess AW; Busam D; Zhao Q; Strausberg RL; Gibbs P; Sieber OM, 2013, 'SMAD2, SMAD3 and SMAD4 Mutations in Colorectal Cancer', Cancer Research, vol. 73, no. 2, pp. 725 - 735, http://dx.doi.org/10.1158/0008-5472.CAN-12-2706 Ward RL; Hicks S; Hawkins NJ, 2013, 'Population-based molecular screening for Lynch syndrome: implications for personalized medicine.', Journal of Clinical Oncology, vol. 31, no. 20, pp. 2554 - 2562, http://dx.doi.org/10.1200/JCO.2012.46.8454 Mouradov D; Gibbs P; Jorissen RN; Lipton L; Sieber OM; Tomlinson IP; Domingo E; Li S; Soo PY; Desai J; Danielsen HE; Oukrif D; Novelli M; Yau C; Holmes CC; Jones IT; McLaughlin S; Molloy P; Hawkins NJ; Ward R; Midgely R; Kerr D, 2013, 'Survival in stage II/III colorectal cancer is independently predicted by chromosomal and microsatellite instability, but not by specific driver mutations', American Journal of Gastroenterology, http://dx.doi.org/10.1038/ajg.2013.292 Metz AJ; Bourke MJ; Moss A; Dower A; Zarzour P; Hawkins NJ; Ward RL; Hesson LB, 2013, 'A correlation of the endoscopic characteristics of colonic laterally spreading tumours with genetic alterations', European Journal of Gastroenterology and Hepatology, vol. 25, no. 3, pp. 319 - 326, http://dx.doi.org/10.1097/MEG.0b013e32835b57e7 Day FL; Jorissen RN; Lipton L; Mouradov D; Sakthianandeswaren A; Christie M; Li S; Tsui C; Tie J; Desai J; Xu ZZ; Molloy P; Whitehall V; Leggett BA; Jones IT; McLaughlin S; Ward RL; Hawkins NJ; Ruszkiewicz AR; Moore J; Busam D; Zhao Q; Strausberg RL; Gibbs P; Sieber OM, 2013, 'PIK3CA and PTEN gene and exon mutation-specific clinicopathologic and molecular associations in Colorectal cancer', Clinical Cancer Research, vol. 19, no. 12, pp. 3285 - 3296, http://dx.doi.org/10.1158/1078-0432.CCR-12-3614