个人简介

Professor Gunning completed his PhD at Monash University on gene expression in the nervous system and then spent 9 years at Stanford University working first on neuronal differentiation and then on the regulation of muscle gene expression. The latter project involved the cloning of the human contractile proteins which facilitated our cloning of the genes encoding the structural proteins of the skeleton of human cells. Since returning to Australia his research group has used these genes to study the assembly of the architecture of cells and tissues. They have discovered that a family of proteins called tropomyosins are used to specify the spatial and temporal properties of the cell skeleton. This has provided an entirely new model to account for the range of architectural structures found in cells and allows them to dissect these different structures using genetically modified mice and cells. Mouse models have allowed them to link specific types of structures with specific physiological processes such as cell/tissue growth, glucose metabolism, muscle contraction and neuronal morphogenesis. These models have also revealed the role of cell architecture in diseases as diverse as cancer and obesity. This knowledge has been used to develop new drugs with the potential to treat childhood cancer and other malignancies. Professor Gunning has published over 140 research papers and recently edited the book "Tropomyosin". He is on the Board of the NSW Cancer Institute and served as the Chair of the NSW Cancer Institute Cancer Research Advisory Committee for 6 years. Professor Gunning was the inaugural Chair of the Division of Research at The Children's Hospital at Westmead, Sydney, and the Founding Chair of Bio-Link Pty Ltd.

研究领域

Molecular Medicine

His research is focussed on diseases of childhood, primarily cancer and muscle damage. Peter is best known for his discovery of one of the key principles underlying the architecture of all cells and its application to childhood cancer. He is also engaged in adult stem cell research to both limit the impact of chemotherapy on children with brain tumours and to enhance the rebuilding of diseased muscles using muscle stem cells.

近期论文

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Chen Y; Gu M; Gunning PW; Russell SM, 2016, 'Dense small molecule labeling enables activator-dependent STORM by proximity mapping', Histochemistry and Cell Biology, pp. 1 - 12, http://dx.doi.org/10.1007/s00418-016-1451-6 Brayford S; Bryce NS; Schevzov G; Haynes EM; Bear JE; Hardeman EC; Gunning PW, 2016, 'Tropomyosin promotes lamellipodial persistence by collaborating with Arp2/3 at the leading edge', Current Biology, vol. 26, no. 10, pp. 1312 - 1318, http://dx.doi.org/10.1016/j.cub.2016.03.028 Knothe Tate ML; Gunning PW; Sansalone V, 2016, 'Emergence of form from function: role of stem cell mechanoadaptation in sealing of cell fate', Bioarchitecture Bonello TT; Janco M; Hook J; Byun A; Appaduray M; Dedova I; Hitchcock-DeGregori S; Hardeman EC; Stehn JR; Böcking T; Gunning PW, 2016, 'A small molecule inhibitor of tropomyosin dissociates actin binding from tropomyosin-directed regulation of actin dynamics', Scientific Reports, vol. 6, http://dx.doi.org/10.1038/srep19816 Kee AJ; Yang L; Lucas CA; Greenberg MJ; Martel N; Leong GM; Hughes WE; Cooney GJ; James DE; Ostap EM; Han W; Gunning PW; Hardeman EC, 2016, 'Corrigendum to An Actin Filament Population Defined by the Tropomyosin Tpm3.1 Regulates Glucose Uptake [Traic, (2015), 16, 7, 691-711]', Traffic, vol. 17, no. 1, pp. 80 - 81, http://dx.doi.org/10.1111/tra.12342 Hu M; Kramer B; Zhang GY; Wang YM; Watson D; Howden B; McCowage G; Alexander IE; Gunning P; Alexander SI, 2015, 'Methyl-guanine-methyl-transferase transgenic bone marrow transplantation allows N, N-bis (2-chloroethyl)-nitrosourea driven donor mixed-chimerism without graft-versus-host disease, and with donor-spec', Transplantation, vol. 99, no. 12, pp. 2476 - 2484, http://dx.doi.org/10.1097/TP.0000000000000825 Erami Z; Herrmann D; Warren SC; Nobis M; McGhee EJ; Lucas MC; Leung W; Reischmann N; Mrowinska A; Schwarz JP; Kadir S; Conway JRW; Vennin C; Karim SA; Campbell AD; Gallego-Ortega D; Magenau A; Murphy KJ; Ridgway RA; Law AM; Walters SN; Grey ST; Croucher DR; Zhang L; Herzog H; Hardeman EC; Gunning PW; Ormandy CJ; Evans TRJ; Strathdee D; Sansom OJ; Morton JP; Anderson KI; Timpson P, 2015, 'Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue', Cell Reports, http://dx.doi.org/10.1016/j.celrep.2015.12.020 Coombes JD; Schevzov G; Kan CY; Petti C; Maritz MF; Whittaker S; Mackenzie KL; Gunning PW, 2015, 'Ras Transformation Overrides a Proliferation Defect Induced by Tpm3.1 Knockout', Cellular and Molecular Biology Letters: an international journal, vol. 20, no. 4, pp. 626 - 646, http://dx.doi.org/10.1515/cmble-2015-0037 Glass JJ; Phillips PA; Gunning PW; Stehn JR, 2015, 'Hypoxia alters the recruitment of tropomyosins into the actin stress fibres of neuroblastoma cells', BMC Cancer, http://dx.doi.org/10.1186/s12885-015-1741-8 Gunning PW; Hardeman EC; Lappalainen P; Mulvihill DP, 2015, 'Tropomyosin - master regulator of actin filament function in the cytoskeleton', Journal of Cell Science, vol. 128, no. 15, pp. 2965 - 2974, http://dx.doi.org/10.1242/jcs.172502 Prunotto M; Bruschi M; Gunning P; Gabbiani G; Weibel F; Ghiggeri GM; Petretto A; Scaloni A; Bonello T; Schevzov G; Alieva I; Bochaton-Piallat ML; Candiano G; Dugina V; Chaponnier C, 2015, 'Stable incorporation of α-smooth muscle actin into stress fibers is dependent on specific tropomyosin isoforms', Cytoskeleton, vol. 72, no. 6, pp. 257 - 267, http://dx.doi.org/10.1002/cm.21230 Schevzov G; Kee AJ; Wang B; Sequeira VB; Hook J; Coombes JD; Lucas CA; Stehn JR; Musgrove EA; Cretu A; Assoian R; Fath T; Hanoch T; Seger R; Pleines I; Kile BT; Hardeman EC; Gunning PW, 2015, 'Regulation of cell proliferation by ERK and signal-dependent nuclear translocation of ERK is dependent on Tm5NM1-containing actin filaments', Molecular Biology of the Cell, vol. 26, no. 13, pp. 2475 - 2490, http://dx.doi.org/10.1091/mbc.E14-10-1453 Gunning PW; Ghoshdastider U; Whitaker S; Popp D; Robinson RC, 2015, 'The evolution of compositionally and functionally distinct actin filaments', Journal of Cell Science, vol. 128, no. 11, pp. 2009 - 2019, http://dx.doi.org/10.1242/jcs.165563 Kee AJ; Yang L; Lucas CA; Greenberg MJ; Martel N; Leong GM; Hughes WE; Cooney GJ; James DE; Ostap EM; Han W; Gunning PW; Hardeman EC, 2015, 'An Actin Filament Population Defined by the Tropomyosin Tpm3.1 Regulates Glucose Uptake', Traffic, vol. 16, no. 7, pp. 691 - 711, http://dx.doi.org/10.1111/tra.12282 Jalilian I; Heu C; Cheng H; Freittag H; Desouza M; Stehn JR; Bryce NS; Whan RM; Hardeman EC; Fath T; Schevzov G; Gunning PW, 2015, 'Cell elasticity is regulated by the tropomyosin isoform composition of the actin cytoskeleton', PLoS One, vol. 10, no. 5, http://dx.doi.org/10.1371/journal.pone.0126214 Caldwell BJ; Lucas C; Kee AJ; Gaus K; Gunning PW; Hardeman EC; Yap AS; Gomez GA, 2015, 'Tropomyosin isoforms support actomyosin biogenesis to generate contractile tension at the epithelial zonula adherens', Cytoskeleton, http://dx.doi.org/10.1002/cm.21202 Lim CY; Bi X; Wu D; Kim JB; Gunning PW; Hong W; Han W, 2015, 'Tropomodulin3 is a novel Akt2 effector regulating insulin-stimulated GLUT4 exocytosis through cortical actin remodeling.', Nature Communications, vol. 6, pp. 5951, http://dx.doi.org/10.1038/ncomms6951 Pleines I; Woods J; Turro E; Foad N; Chappaz S; Lane RM; Manning H; Schevzov G; Westbury SK; Mumford AD; Favier R; Gunning P; Ouwehand WH; Tijssen MR; Kile BT, 2014, 'Mutations in Tropomyosin 4 Cause Macrothrombocytopenia in Mice and Humans', Blood, vol. 124, no. 21, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000349242708059&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a Geeves MA; Hitchcock-DeGregori SE; Gunning PW, 2014, 'A systematic nomenclature for mammalian tropomyosin isoforms', Journal of Muscle Research and Cell Motility, http://dx.doi.org/10.1007/s10974-014-9389-6 Canales CP; Wong ACY; Gunning PW; Housley GD; Hardeman EC; Palmer SJ, 2014, 'The role of GTF2IRD1 in the auditory pathology of Williams–Beuren Syndrome', European Journal of Human Genetics, http://dx.doi.org/10.1038/ejhg.2014.188