研究领域

Neuroscience, Pharmacology, Inflammation

1) Investigation of the role of oxidative stress and NAD metabolism on brain cell death and cellular degeneration. 2) Characterization of the effect of exposure to novel nutritional components (e.g. poly phenols)on the human cellular response to oxidative stress (in vitro and in vivo).

近期论文

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Braidy N; Jugder BE; Poljak A; Jayasena T; Mansour H; Nabavi SM; Sachdev P; Grant R, 2016, 'Resveratrol as a potential therapeutic candidate for the treatment and management of alzheimer’s disease', Current Topics in Medicinal Chemistry, vol. 16, no. 17, pp. 1951 - 1960 De Bie J; Guest J; Guillemin GJ; Grant R, 2016, 'Central kynurenine pathway shift with age in women', Journal of Neurochemistry, vol. 136, no. 5, pp. 995 - 1003, http://dx.doi.org/10.1111/jnc.13496 Guest J; Bilgin A; Hokin B; Mori TA; Croft KD; Grant R, 2015, 'Novel relationships between B12, folate and markers of inflammation, oxidative stress and NAD(H) levels, systemically and in the CNS of a healthy human cohort', Nutritional Neuroscience, vol. 18, no. 8, pp. 355 - 364, http://dx.doi.org/10.1179/1476830515Y.0000000041 Guest J; Guillemin GJ; Heng B; Grant R, 2015, 'Lycopene pretreatment ameliorates acute ethanol induced NAD⁺ depletion in human astroglial cells', Oxidative Medicine and Cellular Longevity, vol. 2015, http://dx.doi.org/10.1155/2015/741612 Braidy N; Poljak A; Grant R; Jayasena T; Mansour H; Chan-Ling T; Smythe G; Sachdev P; Guillemin GJ, 2015, 'Differential expression of sirtuins in the aging rat brain', Frontiers in Cellular Neuroscience, vol. 9, no. MAY, http://dx.doi.org/10.3389/fncel.2015.00167 Grant R; Bilgin A; Guest J; Morris M; Garg M; Pearce R, 2015, 'The Relative Value of Measures of Omega-3 Index, Perceived Stress, Cortisol and Sleep Time in Identifying Depression Among a Cohort of Australian Adolescents', International Journal of Child Health and Nutrition, vol. 4, no. 1, pp. 40 - 49, http://dx.doi.org/10.6000/1929-4247.2015.04.01.4 Sheipouri D; Grant R; Bustamante S; Lovejoy D; Guillemin GJ; Braidy N, 2015, 'Characterisation of the kynurenine pathway in skin-derived fibroblasts and keratinocytes', Journal of Cellular Biochemistry, vol. 116, no. 6, pp. 903 - 922, http://dx.doi.org/10.1002/jcb.25019 Pope B; Hokin B; Grant R, 2015, 'Effect of umbilical cord blood prefreeze variables on postthaw viability', Transfusion, vol. 55, no. 3, pp. 629 - 635, http://dx.doi.org/10.1111/trf.12873 Pope B; Hokin B; Grant R, 2014, 'Effect of maternal iron status on the number of CD34+ stem cells harvested from umbilical cord blood', Transfusion, vol. 54, no. 7, pp. 1876 - 1880, http://dx.doi.org/10.1111/trf.12547 Guest J; Grant R; Garg M; Mori TA; Croft KD; Bilgin A, 2014, 'Cerebrospinal fluid levels of inflammation, oxidative stress and NAD+ are linked to differences in plasma carotenoid concentrations', Journal of Neuroinflammation, vol. 11, http://dx.doi.org/10.1186/1742-2094-11-117 Khor A; Grant R; Guest J; Pope B; Morris M; Tung C; Bilgin A, 2014, 'Postprandial oxidative stress is increased after a phytonutrient-poor food but not after a kilojoule-matched phytonutrient-rich food', Nutrition Research, http://dx.doi.org/10.1016/j.nutres.2014.04.005 Guest J; Grant R; Mori TA; Croft KD, 2014, 'Changes in oxidative damage, inflammation and [NAD(H)] with age in cerebrospinal fluid', PLoS One, vol. 9, no. 1, http://dx.doi.org/10.1371/journal.pone.0085335 Grant; Guest J; Bilgin A; Morris; Garg M; Pearce R, 2013, 'Suboptimal Omega-3 Levels in Australian Adolescents', International Journal of Child Health and Nutrition, http://dx.doi.org/10.6000/1929-4247.2013.02.04.4 Guest J; Garg M; Bilgin A; Grant R, 2013, 'Relationship between central and peripheral fatty acids in humans', Lipids in Health and Disease, vol. 12, no. 1, http://dx.doi.org/10.1186/1476-511X-12-79 Kent L; Morton D; Rankin P; Ward E; Grant R; Gobble J; Diehl H, 2013, 'The effect of a low-fat, plant-based lifestyle intervention (CHIP) on serum HDL levels and the implications for metabolic syndrome status - A cohort study', Nutrition and Metabolism, vol. 10, no. 1, http://dx.doi.org/10.1186/1743-7075-10-58 Braidy N; Jayasena T; Sachdev P; Poljak A; Grant R; Guillemin GJ; Smythe G; Mansour H; Chan-Ling T, 2013, 'Mapping NAD metabolism in the brain of ageing Wistar rats: potential targets for influencing brain senescence', Biogerontology, pp. 1 - 22, http://dx.doi.org/10.1007/s10522-013-9489-5 Braidy N; Lim CK; Grant R; Brew BJ; Guillemin GJ, 2013, 'Serum nicotinamide adenine dinucleotide levels through disease course in multiple sclerosis', Brain Research, vol. 1537, pp. 267 - 272, http://dx.doi.org/10.1016/j.brainres.2013.08.025 Braidy N; Lim CK; Guillemin GJ; Grant R; Brew BJ, 2013, 'Serum nicotinamide adenine dinucleotide levels through disease course in multiple sclerosis', Brain Research, http://dx.doi.org/10.1016/j.brainres.2013.08.025 Pope B; Mitsakos K; Bilgin A; Hokin B; Grant R, 2012, 'Predicting overall viability of cord blood harvests', Transfusion, vol. 52, no. 5, pp. 1079 - 1085, http://dx.doi.org/10.1111/j.1537-2995.2011.03386.x Massudi H; Grant R; Guillemin GJ; Braidy N, 2012, 'NAD + metabolism and oxidative stress: The golden nucleotide on a crown of thorns', Redox Report, vol. 17, no. 1, pp. 28 - 46, http://dx.doi.org/10.1179/1351000212Y.0000000001