研究领域

Lipids; Neuroscience; Vascular Disease; Cell Biology and Gene Regulation; Biochemistry

Professor Brett Garner is a Principal Research Fellow with Neuroscience Research Australia (NeuRA) and conjoint Professor with the School of Medical Sciences, UNSW. Professor Garner's research is focused on lipoprotein metabolism, apolipoprotein structure and cellular lipid metabolism with the aim of elucidating mechanisms that regulate lipid transport. Studies on apolipoprotein-E, apolipoprotein-D and ATP-binding cassette transporters indicate new roles in cell biology, atherosclerosis and neurodegeneration. Studies on the interaction of cellular cholesterol and glycosphingolipid metabolism provide new mechanistic understandings to the dysregulation of lipid transport in atherosclerosis and specific neurodegenerative diseases. These studies have also yielded new potential therapeutic avenues to regulate cellular lipid metabolism.

近期论文

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Li H; Karl T; Garner B, 2015, 'Understanding the function of ABCA7 in Alzheimer's disease', Biochemical Society Transactions, vol. 43, pp. 920 - 923, http://dx.doi.org/10.1042/BST20150105 Murphy KE; Gysbers AM; Abbott SK; Spiro AS; Furuta A; Cooper A; Garner B; Kabuta T; Halliday GM, 2015, 'Lysosomal-associated membrane protein 2 isoforms are differentially affected in early Parkinson's disease', Movement Disorders, vol. 30, no. 12, pp. 1639 - 1647, http://dx.doi.org/10.1002/mds.26141 Abbott SK; Jenner AM; Spiro AS; Batterham M; Halliday GM; Garner B, 2015, 'Fatty acid composition of the anterior cingulate cortex indicates a high susceptibility to lipid peroxidation in Parkinson's disease', Journal of Parkinson's Disease, vol. 5, no. 1, pp. 175 - 185, http://dx.doi.org/10.3233/JPD-140479 Li H; Ruberu K; Muñoz SS; Jenner AM; Spiro A; Zhao H; Rassart E; Sanchez D; Ganfornina MD; Karl T; Garner B, 2014, 'Apolipoprotein D modulates amyloid pathology in APP/PS1 Alzheimer's disease mice', Neurobiology of Aging, http://dx.doi.org/10.1016/j.neurobiolaging.2015.02.010 Couttas TA; Kain N; Daniels B; Lim XYI; Shepherd C; Kril J; Pickford R; Li H; Garner B; Don AS, 2014, 'Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer's disease pathogenesis', Acta Neuropathologica Communications, vol. 2, pp. 9, http://dx.doi.org/10.1186/2051-5960-2-9 Cheng D; Spiro AS; Jenner AM; Garner B; Karl T, 2014, 'Long-term cannabidiol treatment prevents the development of social recognition memory deficits in alzheimer's disease transgenic mice', Journal of Alzheimer's Disease, vol. 42, no. 4, pp. 1383 - 1396, http://dx.doi.org/10.3233/JAD-140921 Cheng D; Low JK; Logge W; Garner B; Karl T, 2014, 'Chronic cannabidiol treatment improves social and object recognition in double transgenic APPswe/PS1ΔE9 mice', Psychopharmacology, vol. 231, no. 15, pp. 3009 - 3017, http://dx.doi.org/10.1007/s00213-014-3478-5 Abbott SK; Li H; Muñoz SS; Knoch B; Batterham M; Murphy KE; Halliday GM; Garner B, 2014, 'Altered ceramide acyl chain length and ceramide synthase gene expression in Parkinson's disease', Movement Disorders, vol. 29, no. 4, pp. 518 - 526, http://dx.doi.org/10.1002/mds.25729 Murphy KE; Gysbers AM; Abbott SK; Tayebi N; Kim WS; Sidransky E; Cooper A; Garner B; Halliday GM, 2014, 'Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson's disease', Brain: a journal of neurology, vol. 137, no. 3, pp. 834 - 848, http://dx.doi.org/10.1093/brain/awt367 Cheng D; Low JK; Logge W; Garner B; Karl T, 2014, 'Novel behavioural characteristics of female APPSwe/PS1δE9 double transgenic mice', Behavioural Brain Research, vol. 260, pp. 111 - 118, http://dx.doi.org/10.1016/j.bbr.2013.11.046 Abbott SK; Jenner AM; Mitchell TW; Brown SHJ; Halliday GM; Garner B, 2013, 'An improved high-throughput lipid extraction method for the analysis of human brain lipids', Lipids, vol. 48, no. 3, pp. 307 - 318, http://dx.doi.org/10.1007/s11745-013-3760-z Bhatia S; Jenner AM; Li H; Ruberu K; Spiro AS; Shepherd CE; Kril JJ; Kain N; Don A; Garner B, 2013, 'Increased apolipoprotein D dimer formation in alzheimer's disease hippocampus is associated with lipid conjugated diene levels', Journal of Alzheimer's Disease, vol. 35, no. 3, pp. 475 - 486, http://dx.doi.org/10.3233/JAD-122278 Cheng D; Logge W; Low JK; Garner B; Karl T, 2013, 'Novel behavioural characteristics of the APPSwe/PS1ΔE9 transgenic mouse model of Alzheimer's disease', Behavioural Brain Research, vol. 245, pp. 120 - 127, http://dx.doi.org/10.1016/j.bbr.2013.02.008 Kim WS; Li H; Ruberu K; Chan S; Elliott DA; Low JK; Cheng D; Karl T; Garner B, 2013, 'Deletion of Abca7 increases cerebral amyloid-β accumulation in the J20 mouse model of Alzheimer's disease', The Journal of Neuroscience, vol. 33, no. 10, pp. 4387 - 4394, http://dx.doi.org/10.1523/JNEUROSCI.4165-12.2013 Karl T; Cheng D; Garner B; Arnold JC, 2012, 'The therapeutic potential of the endocannabinoid system for Alzheimer's disease', Expert Opinion on Therapeutic Targets, vol. 16, no. 4, pp. 407 - 420, http://dx.doi.org/10.1517/14728222.2012.671812 Wong J; Garner B; Halliday GM; Kwok JBJ, 2012, 'Srp20 regulates TrkB pre-mRNA splicing to generate TrkB-Shc transcripts with implications for Alzheimer's disease', Journal of Neurochemistry, vol. 123, no. 1, pp. 159 - 171, http://dx.doi.org/10.1111/j.1471-4159.2012.07873.x Karl T; Bhatia S; Cheng D; Kim WS; Garner B, 2012, 'Cognitive phenotyping of amyloid precursor protein transgenic J20 mice', Behavioural Brain Research, vol. 228, no. 2, pp. 392 - 397, http://dx.doi.org/10.1016/j.bbr.2011.12.021 Logge W; Cheng D; Chesworth R; Bhatia S; Garner B; Kim WS; Karl T, 2012, 'Role of Abca7 in Mouse Behaviours Relevant to Neurodegenerative Diseases', PLoS One, vol. 7, no. 9, http://dx.doi.org/10.1371/journal.pone.0045959 Kim WS; Hill AF; Fitzgerald ML; Freeman MW; Evin G; Garner B, 2011, 'Wild type and tangier disease ABCA1 mutants modulate cellular amyloid-β production independent of cholesterol efflux activity', Journal of Alzheimer's Disease, vol. 27, no. 2, pp. 441 - 452, http://dx.doi.org/10.3233/JAD-2011-110521 Cheng D; Jenner AM; Shui G; Cheong WF; Mitchell TW; Nealon JR; Kim WS; McCann H; Wenk MR; Halliday GM; Garner B, 2011, 'Lipid pathway alterations in parkinson's disease primary visual cortex', PLoS One, vol. 6, no. 2, http://dx.doi.org/10.1371/journal.pone.0017299