研究领域

Receptors and Membrane Biology

Research interests are G-Protein Coupled Receptor (GPCR), activation and regulation by drugs. The mechanisms of GPCR activation are being explored via: (i) investigating the role of the extracellular loops in regulating the activation of GPCRs and as a site of interaction with allosteric modulator drugs in adrenergic, inflammatory (C5aR) and taste receptors (ii) a drug discovery program which is developing urogenital selective α1-adrenoceptor antagonists for the treatment of prostate diseases and adrenoceptor modulators for Rett syndrome, seizure disorders and other neurological conditions.

近期论文

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Chen J; Campbell AP; Urmi KF; Wakelin LPG; Denny WA; Griffith R; Finch AM, 2014, 'Human α1-adrenoceptor subtype selectivity of substituted homobivalent 4-aminoquinolines', Bioorganic and Medicinal Chemistry, vol. 22, no. 21, pp. 5910 - 5916, http://dx.doi.org/10.1016/j.bmc.2014.09.017 Kim MY; Finch AM; Lumbers ER; Boyce AC; Gibson KJ; Eiby YA; Lingwood BE, 2014, 'Expression of adrenoceptor subtypes in preterm piglet heart is different to term heart', PLoS One, vol. 9, no. 3, http://dx.doi.org/10.1371/journal.pone.0092167 Campbell AP; MacDougall IJA; Griffith R; Finch AM, 2014, 'An aspartate in the second extracellular loop of the α1B adrenoceptor regulates agonist binding', European Journal of Pharmacology, vol. 733, no. 1, pp. 90 - 96, http://dx.doi.org/10.1016/j.ejphar.2014.03.034 Ngo T; Nicholas TJ; Chen J; Finch AM; Griffith R, 2013, '5-HT1A receptor pharmacophores to screen for off-target activity of α1-adrenoceptor antagonists', Journal of Computer-Aided Molecular Design, vol. 27, no. 4, pp. 305 - 319, http://dx.doi.org/10.1007/s10822-013-9647-5 Chen J; Murad AK; Wakelin LPG; Denny WA; Griffith R; Finch AM, 2013, 'α1-Adrenoceptor and serotonin 5-HT1A receptor affinity of homobivalent 4-aminoquinoline compounds: An investigation of the effect of linker length', Biochemical Pharmacology, vol. 85, no. 10, pp. 1534 - 1541, http://dx.doi.org/10.1016/j.bcp.2013.03.010 Stoddart ES; Senadheera S; MacDougall IJA; Griffith R; Finch AM, 2011, 'A novel structural framework for α1a/d-adrenoceptor selective antagonists identified using subtype selective pharmacophores', PLoS One, vol. 6, no. 5, http://dx.doi.org/10.1371/journal.pone.0019695 Laird AS; Finch AM; Waite PME; Carrive P, 2008, 'Peripheral changes above and below injury level lead to prolonged vascular responses following high spinal cord injury', American Journal of Physiology: Heart and Circulatory Physiology, vol. 294, no. 2, http://dx.doi.org/10.1152/ajpheart.01002.2007 Riek RP; Finch AA; Begg GE; Graham RM, 2008, 'Wide turn diversity in protein transmembrane helices implications for G-protein-coupled receptor and other polytopic membrane protein structure and function', Molecular Pharmacology, vol. 73, no. 4, pp. 1092 - 1104, http://dx.doi.org/10.1124/mol.107.043042 Antipatis C; Finch A; Ashworth C, 2008, 'Effect of controlled alterations in maternal dietary retinol on foetal and neonatal retinol status and pregnancy outcome in pigs', Livestock Science, vol. 118, pp. 247 - 254 Mcneil CJ; Nwagwu MO; Finch A; Page KP; Thain A; Mcardle HJ; Ashworth C, 2007, 'Glucocorticoid exposure and tissue gene expression of 11â HSD-1, 11 â HSD-2, and glucocorticoid receptor in a porcine model of differential fetal growth', Reproduction, vol. 133, pp. 653 - 661 Finch AM; Graham RM, 2006, 'The alpha(1D)-adrenergic receptor: cinderella or ugly stepsister.', Molecular Pharmacology, vol. 69, no. 1, pp. 1 - 4, http://dx.doi.org/10.1124/mol.105.020230 Du X-J; Gao X-M; Kiriazis H; Moore X-L; Ming Z; Su Y; Wang K; Finch AM; Dart AM; Graham RM, 2006, 'Cardiac overexpression of the alpha(1A)-adrenergic receptor limits post-infarct ventricular remodeling and dysfunction, and improves survival', Journal of Molecular and Cellular Cardiology, vol. 41, no. 4, pp. 735 - 735, http://dx.doi.org/10.1016/j.yjmcc.2006.06.022 Finch AM; Graham RM, 2006, 'The α1D-adrenergic receptor: Cinderella or ugly stepsister', Molecular Pharmacology, vol. 69, no. 1, pp. 1 - 4, http://dx.doi.org/10.1124/mol.105.020230 Du XJ; Gao XM; Kiriazis H; Moore XL; Ming Z; Su Y; Finch AM; Hannan RA; Dart AM; Graham RM, 2006, 'Transgenic α1A-adrenergic activation limits post-infarct ventricular remodeling and dysfunction and improves survival', Cardiovascular Research, vol. 71, no. 4, pp. 735 - 743, http://dx.doi.org/10.1016/j.cardiores.2006.06.015 Mcneil CJ; Finch A; Page KP; Clarke SD; Ashworth C; Mcardle HJ, 2005, 'The effect of fetal pig size and stage of gestation on tissue fatty acid metabolism and profile', Reproduction, vol. 129, no. 6, pp. 757 - 763 Du XJ; Fang L; Gao XM; Kiriazis H; Feng X; Hotchkin E; Finch AM; Chaulet H; Graham RM, 2004, 'Genetic enhancement of ventricular contractility protects against pressure-overload-induced cardiac dysfunction', Journal of Molecular and Cellular Cardiology, vol. 37, no. 5, pp. 979 - 987, http://dx.doi.org/10.1016/j.yjmcc.2004.07.010 McGinty SJ; Finch A; Griffith R; Graham RM; Bremner JB, 2004, 'Synthesis and biological evaluation of bicyclic and tricyclic substituted nortropane derivatives: Discovery of a novel selective α 1D- adrenergic receptor ligand', Bioorganic and Medicinal Chemistry, vol. 12, no. 21, pp. 5639 - 5650, http://dx.doi.org/10.1016/j.bmc.2004.07.063 Finch A; Yang LG; Nwagwu MO; Page KP; Mcardle HJ; Ashworth C, 2004, 'Placental transport of leucine in a porcine model of low birth weight', Reproduction, vol. 128, no. 2, pp. 229 - 235 Page KP; Ashworth C; Mcardle HJ; Finch A; Nwagwu MO, 2003, 'Sodium transport across the chorioallantoic membrane of porcine placenta involves the epithelial sodium channel (ENaC)', The Journal of Physiology, vol. 547, no. 3, pp. 849 - 857, http://dx.doi.org/10.1113/jphysiol.2002.031153 Finch AM; Antipatis C; Pickard AR; Ashworth CJ, 2002, 'Patterns of fetal growth within Large White × Landrace and Chinese Meishan gilt litters at three stages of gestation', Reproduction Fertility and Development, vol. 14, no. 7, pp. 419 - 419, http://dx.doi.org/10.1071/RD01131