研究领域

Neuroscience, Neurodegenerative Diseases, Cell Biology and Gene Regulation, Disease Modelling, Injury

The primary research focus of the lab is on the regulation of the cytoskeleton in injury of the nervous system and neurodegenerative diseases such as Alzheimer's Disease with a particular interest in the microfilament system. For this we employ cell and tissue cultures, prepared from genetically modified mice which express altered levels of the actin dynamics-regulating protein tropomyosin. Other projects in the lab focus on the role of the cytoskeleton in early neuronal development. Recent outcome of these projects demonstrate that tropomyosin isoforms regulate early processes such as neurite formation and branching in an isoform-specific manner.

近期论文

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Tate MLK; Fath T, 2016, 'The Only Constant Is Change: Next Generation Materials and Medical Device Design for Physical and Mental Health', Advanced healthcare materials, http://dx.doi.org/10.1002/adhm.201600437 Brettle M; Patel S; Fath T, 2016, 'Tropomyosins in the healthy and diseased nervous system', Brain Research Bulletin, http://dx.doi.org/10.1016/j.brainresbull.2016.06.004 Gray KT; Suchowerska AK; Bland T; Colpan M; Wayman G; Fath T; Kostyukova AS, 2016, 'Tropomodulin isoforms utilize specific binding functions to modulate dendrite development', Cytoskeleton, vol. 73, no. 6, pp. 316 - 328, http://dx.doi.org/10.1002/cm.21304 Couttas TA; Kain N; Suchowerska AK; Quek LE; Turner N; Fath T; Garner B; Don AS, 2016, 'Loss of ceramide synthase 2 activity, necessary for myelin biosynthesis, precedes tau pathology in the cortical pathogenesis of Alzheimer's disease', Neurobiology of Aging, vol. 43, pp. 89 - 100, http://dx.doi.org/10.1016/j.neurobiolaging.2016.03.027 Stefen H; Chaichim C; Power J; Fath T, 2016, 'Regulation of the Postsynaptic Compartment of Excitatory Synapses by the Actin Cytoskeleton in Health and Its Disruption in Disease', NEURAL PLASTICITY, vol. 2016, http://dx.doi.org/10.1155/2016/2371970 An H; Brettle M; Lee T; Heng B; Lim CK; Guillemin GJ; Lord MS; Klotzsch E; Geczy CL; Bryant K; Fath T; Tedla N, 2016, 'Soluble LILRA3 promotes neurite outgrowth and synapses formation through a high-affinity interaction with Nogo 66', Journal of Cell Science, vol. 129, no. 6, pp. 1198 - 1209, http://dx.doi.org/10.1242/jcs.182006 Sytnyk V; Fath T, 2015, 'Synapse Function in Dementia and Neurodegenerative Disorders', Australian Biochemist, vol. 46, no. 1, https://www.asbmb.org.au/magazine/2015_April_Issue46-1/Showcase%204%20-%20Fath.pdf Brettle M; Suchowerska AK; Chua SW; Ittner LM; Fath T, 2015, 'Amyotrophic lateral sclerosis-associated mutant profilin 1 increases dendritic arborisation and spine formation in primary hippocampal neurons', Neuroscience Letters, vol. 609, pp. 223 - 228, http://dx.doi.org/10.1016/j.neulet.2015.09.034 Schevzov G; Kee AJ; Wang B; Sequeira VB; Hook J; Coombes JD; Lucas CA; Stehn JR; Musgrove EA; Cretu A; Assoian R; Fath T; Hanoch T; Seger R; Pleines I; Kile BT; Hardeman EC; Gunning PW, 2015, 'Regulation of cell proliferation by ERK and signal-dependent nuclear translocation of ERK is dependent on Tm5NM1-containing actin filaments', Molecular Biology of the Cell, vol. 26, no. 13, pp. 2475 - 2490, http://dx.doi.org/10.1091/mbc.E14-10-1453 Jalilian I; Heu C; Cheng H; Freittag H; Desouza M; Stehn JR; Bryce NS; Whan RM; Hardeman EC; Fath T; Schevzov G; Gunning PW, 2015, 'Cell elasticity is regulated by the tropomyosin isoform composition of the actin cytoskeleton', PLoS One, vol. 10, no. 5, http://dx.doi.org/10.1371/journal.pone.0126214 Suchowerska AK; Fath T, 2014, 'Cytoskeletal changes in diseases of the nervous system', Frontiers in Biology, pp. 1 - 13, http://dx.doi.org/10.1007/s11515-014-1290-6 Curthoys NM; Freittag H; Connor A; Desouza M; Brettle M; Poljak A; Hall A; Hardeman E; Schevzov G; Gunning PW; Fath T, 2014, 'Tropomyosins induce neuritogenesis and determine neurite branching patterns in B35 neuroblastoma cells', Molecular and Cellular Neuroscience, vol. 58, pp. 11 - 21, http://dx.doi.org/10.1016/j.mcn.2013.10.011 Stehn JR; Haass NK; Bonello T; Desouza M; Kottyan G; Treutlein H; Zeng J; Nascimento PRBB; Sequeira VB; Butler TL; Allanson M; Fath T; Hill TA; McCluskey A; Schevzov G; Palmer SJ; Hardeman EC; Winlaw D; Reeve VE; Dixon I; Weninger W; Cripe TP; Gunning PW, 2013, 'A Novel Class of Anticancer Compounds Targets the Actin Cytoskeleton in Tumor Cells', Cancer Research, vol. 73, no. 16, pp. 5169 - 5182, http://dx.doi.org/10.1158/0008-5472.CAN-12-4501 Fath T, 2013, 'Tropomodulins and tropomyosins - Organizers of cellular microcompartments', Biomolecular Concepts, vol. 4, no. 1, pp. 89 - 101, http://dx.doi.org/10.1515/bmc-2012-0037 Schevzov G; Curthoys NM; Gunning PW; Fath T, 2012, 'Functional Diversity of Actin Cytoskeleton in Neurons and its Regulation by Tropomyosin', International review of cell and molecular biology, vol. 298, pp. 33 - 94, http://dx.doi.org/10.1016/B978-0-12-394309-5.00002-X Dale RC; Merheb V; Pillai S; Wang D; Cantrill L; Murphy TK; Ben-Pazi H; Varadkar S; Aumann TD; Horne MK; Church AJ; Fath T; Brilot F, 2012, 'Antibodies to surface dopamine-2 receptor in autoimmune movement and psychiatric disorders', Brain: a journal of neurology, vol. 135, no. 11, pp. 3453 - 3468, http://dx.doi.org/10.1093/brain/aws256 Schevzov G; Whittaker SP; Fath T; Lin JJ-C; Gunning PW, 2011, 'Tropomyosin isoforms and reagents', Bioarchitecture, vol. 1, no. 4, pp. 135 - 164, http://dx.doi.org/10.4161/bioa.1.4.17897 Guven K; Gunning P; Fath T, 2011, 'TPM3 and TPM4 gene products segregate to the postsynaptic region of central nervous system synapses.', Bioarchitecture, vol. 1, no. 6, pp. 284 - 289, http://dx.doi.org/10.4161/bioa.1.6.19336 Fath T; Fischer RS; Dehmelt L; Halpain S; Fowler VM, 2011, 'Tropomodulins are negative regulators of neurite outgrowth', European Journal of Cell Biology, vol. 90, no. 4, pp. 291 - 300, http://dx.doi.org/10.1016/j.ejcb.2010.10.014 Hundelt M; Fath T; Selle K; Oesterwind K; Jordan J; Schultz C; Götz J; von Engelhardt J; Monyer H; Lewejohann L; Sachser N; Bakota L; Brandt R, 2011, 'Altered phosphorylation but no neurodegeneration in a mouse model of tau hyperphosphorylation', Neurobiology of Aging, vol. 32, no. 6, pp. 991 - 1006, http://dx.doi.org/10.1016/j.neurobiolaging.2009.06.007