个人简介

Danny Eckert is a Principal Research Fellow at Neuroscience Research Australia (NeuRA), a NHMRC RD Wright Fellow, and a Conjoint Associate Professor in the School of Medical Sciences, UNSW.

研究领域

Respiratory Diseases

Dr Eckert is a sleep and respiratory physiologist. His research based at NeuRA focusses on investigating various aspects of sleep and upper airway physiology in humans. One of the primary goals is to investigate the multiple pathogenic causes of a common sleep-related breathing disorder, obstructive sleep apnoea, to identify novel therapeutic targets and develop new individualised approaches for therapy. A variety of neurophysiological techniques to study human upper airway muscle activity, function, and airway mechanics during wakefulness and sleep are utilised as part of a comprehensive basic sciences and translational sleep research program. Current NHMRC funded projects include: determining the mechanisms of upper airway muscle dysfunction in sleep apnoea, assessing the role of a variety of pharmacological agents on upper airway physiology and sleep-disordered breathing in humans, determining why people with spinal cord injury get sleep apnoea, understanding the bidirectional relationship between sleep and the brain (NeuroSleep CRE), and the potential for targeted interventions to improve sleep.

近期论文

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Martins RT; Carberry JC; Eckert DJ, 2016, 'Breath-to-breath reflex modulation of genioglossus muscle activity in obstructive sleep apnea.', Sleep Medicine, vol. 21, pp. 45 - 46, http://dx.doi.org/10.1016/j.sleep.2016.02.003 Eckert DJ; Oliven A, 2016, 'When insulin has to work hard to keep the sugar at bay the upper airway collapses away.', European Respiratory Journal, vol. 47, no. 6, pp. 1611 - 1614, http://dx.doi.org/10.1183/13993003.00590-2016 Carter SG; Berger MS; Carberry JC; Bilston LE; Butler JE; Tong BKY; Martins RT; Fisher LP; McKenzie DK; Grunstein RR; Eckert DJ, 2016, 'Zopiclone increases the arousal threshold without impairing genioglossus activity in obstructive sleep apnea', Sleep, vol. 39, no. 4, pp. 757 - 766, http://dx.doi.org/10.5665/sleep.5622 Nguyen CD; Wellman A; Jordan AS; Eckert DJ, 2016, 'Mild airflow limitation during N2 sleep increases K-complex frequency and slows electroencephalographic activity', Sleep, vol. 39, no. 3, pp. 541 - 550, http://dx.doi.org/10.5665/sleep.5522 Carberry JC; Jordan AS; White DP; Wellman A; Eckert DJ, 2016, 'Upper airway collapsibility (Pcrit) and pharyngeal dilator muscle activity are sleep stage dependent', Sleep, vol. 39, no. 3, pp. 511 - 521, http://dx.doi.org/10.5665/sleep.5516 Taranto-Montemurro L; Edwards BA; Sands SA; Marques M; Eckert DJ; White DP; Wellman A, 2016, 'Desipramine Increases Genioglossus Activity and Reduces Upper Airway Collapsibility During Non-REM Sleep in Healthy Subjects.', American Journal of Respiratory and Critical Care Medicine, http://dx.doi.org/10.1164/rccm.201511-2172OC Martins RT; Currow DC; Abernethy AP; Johnson MJ; Toson B; Eckert DJ, 2016, 'Effects of low-dose morphine on perceived sleep quality in patients with refractory breathlessness: A hypothesis generating study.', Respirology, vol. 21, no. 2, pp. 386 - 391, http://dx.doi.org/10.1111/resp.12681 Terrill PI; Edwards BA; Nemati S; Butler JP; Owens RL; Eckert DJ; White DP; Malhotra A; Wellman A; Sands SA, 2015, 'Quantifying the ventilatory control contribution to sleep apnoea using polysomnography', European Respiratory Journal, vol. 45, no. 2, pp. 408 - 418, http://dx.doi.org/10.1183/09031936.00062914 Carberry JC; Hensen H; Fisher LP; Saboisky JP; Butler JE; Gandevia SC; Eckert DJ, 2015, 'Mechanisms contributing to the response of upper-airway muscles to changes in airway pressure', Journal of Applied Physiology, vol. 118, no. 10, pp. 1221 - 1228, http://dx.doi.org/10.1152/japplphysiol.01103.2014 Owens RL; Edwards BA; Eckert DJ; Jordan AS; Sands SA; Malhotra A; White DP; Loring SH; Butler JP; Wellman A, 2015, 'An integrative model of physiological traits can be used to predict obstructive sleep apnea and response to non positive airway pressure therapy', Sleep, vol. 38, no. 6, pp. 961 - 970, http://dx.doi.org/10.5665/sleep.4750 Jordan AS; Cori JM; Dawson A; Nicholas CL; O'Donoghue FJ; Catcheside PG; Eckert DJ; McEvoy RD; Trinder J, 2015, 'Arousal from sleep does not lead to reduced dilator muscle activity or elevated upper airway resistance on return to sleep in healthy individuals', Sleep, vol. 38, no. 1, pp. 53 - 59, http://dx.doi.org/10.5665/sleep.4324 Sands SA; Eckert DJ; Jordan AS; Edwards BA; Owens RL; Butler JP; Schwab RJ; Loring SH; Malhotra A; White DP; Wellman A, 2014, 'Enhanced upper-airway muscle responsiveness is a distinct feature of overweight/obese individuals without sleep apnea', American Journal of Respiratory and Critical Care Medicine, vol. 190, no. 8, pp. 930 - 937, http://dx.doi.org/10.1164/rccm.201404-0783OC Edwards BA; Eckert DJ; McSharry DG; Sands SA; Desai A; Kehlmann G; Bakker JP; Genta PR; Owens RL; White DP; Wellman A; Malhotra A, 2014, 'Clinical predictors of the respiratory arousal threshold in patients with obstructive sleep apnea', American Journal of Respiratory and Critical Care Medicine, vol. 190, no. 11, pp. 1293 - 1300, http://dx.doi.org/10.1164/rccm.201404-0718OC Genta PR; Schorr F; Eckert DJ; Gebrim E; Kayamori F; Moriya HT; Malhotra A; Lorenzi-Filho G, 2014, 'Upper airway collapsibility is associated with obesity and hyoid position.', Sleep, vol. 37, no. 10, pp. 1673 - 1678 Genta PR; Owens RL; Edwards BA; Sands SA; Eckert DJ; Butler JP; Loring SH; Malhotra A; Jackson AC; White DP; Wellman A, 2014, 'Influence of pharyngeal muscle activity on inspiratory negative effort dependence in the human upper airway', Respiratory Physiology and Neurobiology, vol. 201, pp. 55 - 59, http://dx.doi.org/10.1016/j.resp.2014.07.005 Edwards BA; Wellman A; Sands SA; Owens RL; Eckert DJ; White DP; Malhotra A, 2014, 'Obstructive sleep apnea in older adults is a distinctly different physiological phenotype.', Sleep, vol. 37, no. 7, pp. 1227 - 1236, http://dx.doi.org/10.5665/sleep.3844 Owens RL; Edwards BA; Sands SA; Butler JP; Eckert DJ; White DP; Malhotra A; Wellman A, 2014, 'The classical Starling resistor model often does not predict inspiratory airflow patterns in the human upper airway', Journal of Applied Physiology, vol. 116, no. 8, pp. 1105 - 1112, http://dx.doi.org/10.1152/japplphysiol.00853.2013 Teodorescu M; Xie A; Sorkness CA; Robbins J; Reeder S; Gong Y; Fedie JE; Sexton A; Miller B; Huard T; Hind J; Bioty N; Peterson E; Kunselman SJ; Chinchilli VM; Soler X; Ramsdell J; Loredo J; Israel E; Eckert DJ; Malhotra A, 2014, 'Effects of Inhaled Fluticasone on Upper Airway during Sleep and Wakefulness in Asthma: A Pilot Study', The Journal of Clinical Sleep Medicine, vol. 10, no. 8, pp. 183 - 193D, http://dx.doi.org/10.5664/jcsm.3450 Martins RT; Eckert DJ, 2014, 'Central Sleep Apnea due to Other Medical Disorders', Sleep Medicine Clinics, vol. 9, no. 1, pp. 57 - 67, http://dx.doi.org/10.1016/j.jsmc.2013.10.002 Eckert DJ; Malhotra A; Wellman A; White DP, 2014, 'Trazodone Increases the Respiratory Arousal Threshold in Obstructive Sleep Apnea Patients with a Low Arousal Threshold', Sleep, vol. 37, no. 4, pp. 811 - 819, http://dx.doi.org/10.5665/sleep.3596