Chin, Jason William - University of Cambridge

个人简介

Professional 2010- Head, Centre for Chemical & Synthetic Biology (CCSB@LMB)MRC Laboratory of Molecular Biology, Cambridge, UK 2010- Professor of Chemistry & Chemical Biology(0.2 FTE, Director of Research 2010-2012)Department of Chemistry, University of Cambridge, UK 2007- Programme Leader (tenured), Cambridge, UK 2007- Fellow in Natural Sciences & Director of Studies in Biochemistry Trinity College, Cambridge University, UK 2003-2007 Programme Leader (tenure-track)MRC Laboratory of Molecular Biology, Cambridge, UK 2001-2003 Postdoctoral Fellow (with Professor Peter G. Schultz.)The Scripps Research Institute, La Jolla, CA, USA 1996-2001 PhD (with Professor Alanna Schepartz.) Yale University, New Haven, CT, USA 1995-1996 Undergraduate Part II Research (with Professor John D. Sutherland.)University of Oxford, Oxford Centre for Molecular Sciences, Oxford, UK Education Oxford University, Oxford, U.K. M.A. 1996 Chemistry Yale University, New Haven, CT, U.S.A. Ph.D. 2001 Organic Chemistry

研究领域

Genetic code expansion in model organisms Photochemical genetics Protein labeling and imaging Post-translational modifications

近期论文

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Trapping biosynthetic acyl-enzyme intermediates with encoded 2,3-diaminopropionic acid. Nature. 2019 565:112-117 Huguenin-Dezot, D. A. Alonzo, G. W. Heberlig, M. Mahesh, D. P. Nguyen, M. H. Dornan, C. N. Boddy, T. M. Schmeing, J. W. Chin. Controlling orthogonal ribosome subunit interactions enables evolution of new function. Nature. 2018 564:444-448 W. H. Schmied, Z. Tnimov, C. Uttamapinant, C. D. Rae, S. D. Fried, J.W. Chin. Translational switching of Cry1 protein expression confers reversible control of circadian behavior in arrythmic Cry-deficient mice. Proc. Natl. Acad. Sci. 2018 26:115 E. Maywood, T. Elliott, A. Patton, T. Krogager, J. Chesham, R. Ernst, V. Beranek, J. W. Chin, M. H. Hastings. An Evolved Methanomethylophilus alvus Pyrrolysyl-tRNA Synthetase/tRNA pair is Highly Active and Orthogonal in Mammalian Cells.Biochemistry. 2018 58:387–390 V. Beranek, J.C.W.Willis, J. W. Chin. A conformational sensor based on genetic code expansion reveals an autocatalytic component in EGFR activation.Nature Comms. 2018 9:3874.M. Baumdick, M. Gelleri, C. Uttamapinant, V . Beranek, J. W. Chin, P. I. H. Bastiaens. Mitotic phosphorylation regulates the spindle localization of the chaperone Hsp72 by uncoupling ATP binding from substrate release.Science Signalling. 2018 11:eaao2464.M. Mukherjee, S. Sabir, L. O. Regan, J. Sampson, M. W. Richards, N. Huguenin-Dezot, J. R. Ault, J. W. Chin, A. Zhuraieva, A. M. Fry, R. Bayliss. Pyrophosphorylation via selective phosphoprotein derivatization.Chem. Sci. 2018 9:5929-5936 A. M. Marmelstein, J. A. M. Morgan, M. Penkert, D. T. Rogerson, J. W. Chin, E. Krause, D. Fiedler. Genetically endcoded protein phosphorylation in mammalian cells.Cell Chem. Biol. 2018 25:1067-1074 V. Beranek, C. D.Reinkemeier, M. S. Zhang, A. D. Liang, G. Kym, J.W. Chin. Mutually orthogonal pyrrolysyl-tRNA synthetase/tRNA pairs.Nature Chem. 2018 10:831-837 J.C.W. Willis, J.W. Chin. Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21.eLIFE. 2018 7:e32660 C. Dickson, A. Fletcher, M. Vaysburd, J.-C. Yang, D.L. Mallery, J. Zeng, C.M. Johnson, S.H. Mclaughlin, M. Skehel, S. Maslen, J. Cruikshank, N. Huguenin-Dezot, J. W. Chin, D. Neuhaus, L.C. James Mitotic spindle association of TACC3 requires Aurora-A-dependent stabilization of a cryptic α-helix.EMBO. J. 2018 37:e97902 S. G. Burgess, M. Murkherjee, S. Sabir, N. Joseph, C. Gutiérrez-Caballero, M.W. Richards, N. Huguenin-Dezot, J.W. Chin, E.J. Kennedy, M. Pfuhl, S.J. Royle, F. Gergely, R. Bayliss. Detecting RNA base methylations in single cells by in situ hybridization.Nature Comms. 2018 9:655 R. T. Ranasinghe, M. R. Challand, K. A. Ganzinger, B. W. Lewis, C. Softley, W. H. Schmied, M. H. Horrocks, N. Shivji, J. W. Chin, J. Spencer, D. Klenerman. Rapid and efficient generation of stable antibody drug conjugates via an encoded cyclopropene and an inverse electron demand Diels Alder reaction.Angew. Chem. 2018 57:2831–2834.B. Oller-Salvia, G.Kym, J.W. Chin. An Orthogonal Central Dogma. Nature Chem Biol. 2018 16;14:103-106 C. Liu, M. Jewett, J.W. Chin, C. A. Voigt. Labelling and identifying cell-type-specific proteomes in the mouse brain.Nature Biotech. 2018 36:156-159.T. P. Krogager, R. J. Ernst, T. S. Elliott, L. Calo, V. Beranek, E. Ciabatti, M. Grazia Spilantini, M. Tripodi, M. H. Hastings, J. W. Chin. Encoding Optical control in LCK kinase to quantitatively investigate its activity in live cells.Nature Struct. Mol. Biol. 2017 24:1155-1163 A. Liaunardy-Jopeace, B.L. Murton, M. Mahesh, J.W. Chin, J.R. James. Expanding and Reprogramming the Genetic Code.ature. 2017 550:53-60 J. W. Chin. Computationally guided discovery of reactive, hydrophilic trans-5-oxocene dienophile for bioorthogonal labeling.Org. Biomol. Chem. 2017 15:6640-6644 W.D Lamber, S. L. Scinto, O. Dmiternko, S.J. Boyd, R. Magboo, R. A. Mehl, J. W. Chin, J.M. Fox, S. Wallace. Intein Zymogens: Conditional Assembly and Splicing of Split Inteins via Targeted Proteolysis J. Am. Chem. Soc. 2017 5139:8074-8077 J.A. Gramespacher, A.J. Stevens, D.P. Nguyen, J.W. Chin, T.W. Muir. Biosynthesis and genetic encoding of phosphothreonine through parallel selection and deep sequencing. Nature Meths. 2017 14: 729-736 M.S Zhang, S.F. Brunner, N. Huguenin-Dezot, A.D. Liang, W.H. Schmied, D.T. Rogerson, J.W. Chin.