个人简介

Education PhD, Stanford University, USA (2010) MSc, IIT Kanpur, India (2004) Professional Experience Postdoctoral Fellow, School of Medical Sciences, UNSW Australia (2014 - current) Glenn Postdoctoral Fellow, Department of Biology, Massachusetts Institute of Technology, USA (2010 - 2014) Graduate Student Researcher, Department of Chemistry, Stanford University, USA (2004 - 2010)

研究领域

Biochemistry and Cell Biology

Sirtuins and NAD+ metabolism in aging and age-related diseases Wound healing in diabetes and ageing Muscle injury and stem cells

近期论文

查看导师新发文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Libert, S.; Pointer, K.; Bell, E. L.; Das, A.; Cohen, D. E.; Asara, J. M.; Kapur, K.; Bergmann, S.; Preisig, M.; Otowa, T.; Kendler, K. S.; Chen, X.; Hettema, J. M.; van den Oord, E. J.; Rubio, J. P.; Guarente, L. “SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive.” Cell 2011, 147(7), 1459-1472. Das, A.; Szu, Ping-Hui, Fitzgerald, J. T., Khosla, C. “Mechanism and engineering of polyketide chain initiation in fredericamycin biosynthesis.” J. Am. Chem. Soc. 2010, 132, 8831-8833. Das, A.; Khosla, C. “In vivo and in vitro analysis of the hedamycin polyketide synthase.” Chemistry and Biology 2009, 16, 1197-1207. Das, A.; Khosla, C. “Biosynthesis of aromatic polyketides in bacteria.” Accounts of Chemical Research 2009, 42, 631-639. Lee, T.S.; Das, A.; Khosla, C. “Structure-activity relationships of semisynthetic Mumbaistatin analogs.” Bioorganic and Medicinal Chemistry 2007, 15, 5207-5218. Mohamad M; Mitchell SJ; Wu LE; White MY; Cordwell SJ; Mach J; Solon-Biet SM; Boyer D; Nines D; Das A; Catherine Li SY; Warren A; Hilmer SN; Fraser R; Sinclair DA; Simpson SJ; de Cabo R; Le Couteur DG; Cogger VC, 2016, 'Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance', Aging Cell, vol. 15, no. 4, pp. 706 - 715, http://dx.doi.org/10.1111/acel.12481 Mohamad M; Mitchell SJ; Wu LE; White MY; Cordwell SJ; Mach J; Solon-Biet SM; Boyer D; Nines D; Das A; Catherine Li SY; Warren A; Hilmer SN; Fraser R; Sinclair DA; Simpson SJ; de Cabo R; Le Couteur DG; Cogger VC, 2016, 'Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance', Aging Cell, http://dx.doi.org/10.1111/acel.12481 Javidpour P; Das A; Khosla C; Tsai S-C, 2011, 'Structural and Biochemical Studies of the Hedamycin Type II Polyketide Ketoreductase ( Hed KR): Molecular Basis of Stereo- and Regiospecificities', Biochemistry, vol. 50, no. 34, pp. 7426 - 7439, http://dx.doi.org/10.1021/bi2006866 Szu P-H; Govindarajan S; Meehan MJ; Das A; Nguyen DD; Dorrestein PC; Minshull J; Khosla C, 2011, 'Analysis of the Ketosynthase-Chain Length Factor Heterodimer from the Fredericamycin Polyketide Synthase', Chemistry and Biology, vol. 18, no. 8, pp. 1021 - 1031, http://dx.doi.org/10.1016/j.chembiol.2011.07.015 Libert S; Pointer K; Bell EL; Das A; Cohen DE; Asara JM; Kapur K; Bergmann S; Preisig M; Otowa T; Kendler KS; Chen X; Hettema JM; van den Oord EJ; Rubio JP; Guarente L, 2011, 'SIRT1 Activates MAO-A in the Brain to Mediate Anxiety and Exploratory Drive', Cell, vol. 147, no. 7, pp. 1459 - 1472, http://dx.doi.org/10.1016/j.cell.2011.10.054 Tahanian E; Lord-Dufour S; Das A; Khosla C; Roy R; Annabi B, 2010, 'Inhibition of Tubulogenesis and of Carcinogen-mediated Signaling in Brain Endothelial Cells Highlight the Antiangiogenic Properties of a Mumbaistatin Analog', Chemical Biology and Drug Design, vol. 75, no. 5, pp. 481 - 488, http://dx.doi.org/10.1111/j.1747-0285.2010.00961.x Das A; Szu P-H; Fitzgerald JT; Khosla C, 2010, 'Mechanism and Engineering of Polyketide Chain Initiation in Fredericamycin Biosynthesis', Journal of the American Chemical Society, vol. 132, no. 26, pp. 8831 - 8833, http://dx.doi.org/10.1021/ja102517q Das A; Khosla C, 2009, 'Biosynthesis of Aromatic Polyketides in Bacteria', Accounts of Chemical Research, vol. 42, no. 5, pp. 631 - 639, http://dx.doi.org/10.1021/ar8002249 Das A; Khosla C, 2009, 'In Vivo and In Vitro Analysis of the Hedamycin Polyketide Synthase', Chemistry and Biology, vol. 16, no. 11, pp. 1197 - 1207, http://dx.doi.org/10.1016/j.chembiol.2009.11.005 Lee TS; Das A; Khosla C, 2007, 'Structure–activity relationships of semisynthetic mumbaistatin analogs', Bioorganic and Medicinal Chemistry, vol. 15, no. 15, pp. 5207 - 5218, http://dx.doi.org/10.1016/j.bmc.2007.05.019