个人简介

Dr Amanda Craig is a Lecturer with the Translational Neuroscience Facility in the Department of Physiology, School of Medical Sciences.

研究领域

Neurosciences

Her research interests are centred around stroke. Stroke is the leading cause of death and long-term disability in adults. Approximately 80% of all strokes suffered are ischaemic, resulting from artery occlusion and causing a lack of perfusion at the core of the infarct and reduced perfusion at the margin of the blood vessels territory (penumbra). The extent of neurological damage following stroke and the severity of the neurological sequelae depend on the viability of the penumbra. Cellular and molecular pathways triggered from the occlusion lead to necrosis, apoptosis and neuroinflammation with subsequent neuronal loss. The devastation of stroke could be greatly ameliorated if therapies were available to salvage these potentially viable neurons in the penumbra. Therefore the cellular and molecular pathways that are involved in neuronal cell injury following ischaemia are a prime target for the development of improved therapies.

近期论文

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Craig AJ; Housley GD, 2016, 'Evaluation of gene therapy as an intervention strategy to treat brain injury from stroke', Frontiers in Molecular Neuroscience, vol. 9, no. MAY, http://dx.doi.org/10.3389/fnmol.2016.00034 Meloni BP; Craig AJ; Knuckey NW; Milech N; Hopkins RM; Watt PM, 2013, 'The Neuroprotective Efficacy of Cell-Penetrating Peptides TAT, Penetratin, Arg-9, and Pep-1 in Glutamic Acid, Kainic Acid, and In Vitro Ischemia Injury Models Using Primary Cortical Neuronal Cultures', Cellular and Molecular Neurobiology, pp. 1 - 9, http://dx.doi.org/10.1007/s10571-013-9999-3 Cross JL; Boulos S; Shepherd KL; Craig AJ; Lee S; Bakker AJ; Knuckey NW; Meloni BP, 2012, 'High level over-expression of different NCX isoforms in HEK293 cell lines and primary neuronal cultures is protective following oxygen glucose deprivation', Neuroscience Research, vol. 73, no. 3, pp. 191 - 198, http://dx.doi.org/10.1016/j.neures.2012.04.007 Meloni BP; Meade AJ; Kitikomolsuk D; Knuckey NW, 2011, 'Characterisation of neuronal cell death in acute and delayed in vitro ischemia (oxygen-glucose deprivation) models', Journal of Neuroscience Methods, vol. 195, no. 1, pp. 67 - 74, http://dx.doi.org/10.1016/j.jneumeth.2010.11.023 Craig AJ; Meloni BP; Watt P; Knuckey NW, 2011, 'Attenuation of neuronal death by peptide inhibitors of AP-1 activation in acute and delayed in vitro ischaemia (oxygen/glucose deprivation) models', International Journal of Peptide Research and Therapeutics, vol. 17, no. 1, pp. 1 - 6, http://dx.doi.org/10.1007/s10989-010-9234-8 Gow WR; Campbell K; Meade AJ; Watt PM; Milech N; Knuckey NW; Meloni BP, 2011, 'Lack of neuroprotection of inhibitory peptides targeting Jun/JNK after transient focal cerebral ischemia in Spontaneously Hypertensive rats', Journal of Cerebral Blood Flow and Metabolism, vol. 31, no. 12, http://dx.doi.org/10.1038/jcbfm.2011.140 Meade AJ; Meloni BP; Cross J; Bakker AJ; Fear MW; Mastaglia FL; Watt PM; Knuckey NW, 2010, 'AP-1 inhibitory peptides are neuroprotective following acute glutamate excitotoxicity in primary cortical neuronal cultures', Journal of Neurochemistry, vol. 112, no. 1, pp. 258 - 270, http://dx.doi.org/10.1111/j.1471-4159.2009.06459.x Meade AJ; Meloni BP; Mastaglia FL; Watt PM; Knuckey NW, 2010, 'AP-1 inhibitory peptides attenuate in vitro cortical neuronal cell death induced by kainic acid', Brain Research, vol. 1360, pp. 8 - 16, http://dx.doi.org/10.1016/j.brainres.2010.09.007