Chisholm, Orin - University of New South Wales

个人简介

Orin Chisholm is the Program Authority and Senior Lecturer in Pharmaceutical Medicine in the School of Medical Sciences at UNSW a position she has held since late 2012. After undergraduate studies in biochemistry at The University of Sydney and doctoral studies in molecular biology and oncology at the Children’s Medical Research Foundation, Orin followed a research and academic pathway for several years. She undertook research appointments at leading medical research institutes in New York, Melbourne, Canberra and Sydney, where her research focussed on a molecular understanding of haemopoiesis. She also expertise in undergraduate and postgraduate teaching in the areas of biochemistry, molecular genetics, immunology and biotechnology. Orin has considerable work experience in the pharmaceutical industry, predominantly in the area of Regulatory Affairs, where she has over 12 years experience. She has worked in both large pharmaceutical and smaller biotechnology companies in Australia. She has particular expertise in the registration of biotechnology products for oncology indications. She also worked at Medicines Australia as their scientific manager during the initial consultation period for ANZTPA. She lectured from 2005-2012 at the University of Sydney in their Molecular Biotechnology program on the regulation of biotechnology products in Australia.

研究领域

Pharmaceutical Sciences

1. Regulatory science and Pharmaceutical Medicine 2. The scholarship of learning and teaching in pharmaceutical medicine and personalised medicine

近期论文

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Chisholm OT, 2015, 'Proposed changes to US therapeutic products regulation', The Source Document, no. 24, pp. 7 - 9 Badolato J; Chisholm OT; Holmes M, 2013, 'ARCS Australia University Partnerships.', The Source, no. 19, pp. 34 - 34 Marsh IB; Whittington RJ; ORourke B; Hyatt AD; Chisholm O, 2002, 'Rapid differentiation of Australian, European and American ranaviruses based on variation in major capsid protein gene sequence', Molecular and Cellular Probes, vol. 16, no. 2, pp. 137 - 151, http://dx.doi.org/10.1006/mcpr.2001.0400 Ryan GR; Dai XM; Dominguez MG; Tong W; Chuan F; Chisholm O; Russell RG; Pollard JW; Richard Stanley E, 2001, 'Rescue of the colony-stimulating factor 1 (CSF-1)-nullizygous mouse (Csf1op/Csf1op) phenotype with a CSF-1 transgene and identification of sites of local CSF-1 synthesis', Blood, vol. 98, no. 1, pp. 74 - 84, http://dx.doi.org/10.1182/blood.V98.1.74 Sungaran R; Chisholm O, 2001, 'Thrombopoietin gene regulation - A review', Hematology, vol. 6, no. 1, pp. 41 - 46 Sungaran R; Chisholm OT; Markovic B; Khachigian LM; Tanaka Y; Chong BH, 2000, 'The role of platelet alpha-granular proteins in the regulation of thrombopoietin messenger RNA expression in human bone marrow stromal cells', Blood, vol. 95, no. 10, pp. 3094 - 3101, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000086951000014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a Yang M; Hogg PJ; Chisholm OT; Li K; Chesterman CN; Chong BH, 1999, 'TSP1 inhibits PEG-rHuMGDF-induced mega karyocytopoiesis via TSP/TSP receptor interaction.', Blood, vol. 94, no. 10, pp. 41A - 41A, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000083790300218&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a Yang M; Li K; Lam AC; Chui CMY; Yuen PMP; Chisholm OT; Chesterman CN; Chong BH, 1999, 'PDGF indirectly enhanced granulopoiesis.', Blood, vol. 94, no. 10, pp. 46B - 46B, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000083790700200&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a Chisholm O; Fahmy R; Tao H; Holmes M; Chong B, 1999, 'Transcription factor and cell surface protein expression during megakaryocyte differentiation.', Experimental Hematology, vol. 27, no. 7, pp. 102 - 102, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000081030100250&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a Holmes M; Turner J; Fox A; Chisholm O; Crossley M; Chong B, 1999, 'hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2 and modulates GATA-mediated activation', Journal of Biological Chemistry, vol. 274, no. 33, pp. 23491 - 23498, http://dx.doi.org/10.1074/jbc.274.33.23491 Cohen PE; Chisholm O; Arceci RJ; Stanley ER; Pollard JW, 1996, 'Absence of colony-stimulating factor-1 in osteopetrotic (csfm(op)/csfm(op)) mice results in male fertility defects', Biology of Reproduction, vol. 55, no. 2, pp. 310 - 317 Chang MDY; Stanley ER; Khalili H; Chisholm O; Pollard JW, 1995, 'Osteopetrotic (op/op) Mice Deficient in Macrophages Have the Ability to Mount a Normal T-Cell-Dependent Immune Response', Cellular Immunology, vol. 162, no. 1, pp. 146 - 152, http://dx.doi.org/10.1006/cimm.1995.1062 CHISHOLM O; BERTONCELLO I, 1994, 'ALPHA-4-BETA-1 INTEGRIN EXPRESSION ON SUBSETS OF HEMATOPOIETIC STEM-CELLS', Journal of Cellular Biochemistry, pp. 10 - 10, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1994MV41200025&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a Cecchini MG; Dominguez MG; Mocci S; Wetterwald A; Felix R; Fleisch H; Chisholm O; Hofstetter W; Pollard JW; Stanley ER, 1994, 'Role of colony stimulating factor-1 in the establishment and regulation of tissue macrophages during postnatal development of the mouse', Development (Cambridge), vol. 120, no. 6, pp. 1357 - 1372 CHISHOLM O; BERTONCELLO I, 1993, 'DOES EXPRESSION OF THE ALPHA-4-BETA-1 INTEGRIN CHANGE WITH THE PROLIFERATIVE AND DIFFERENTIATIVE CAPACITY OF MURINE PRIMITIVE HEMATOPOIETIC STEM-CELLS', Journal of Leukocyte Biology, pp. 101 - 101, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1993ME18500405&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a Begg SK; Radley JM; Pollard JW; Chisholm OT; Stanley ER; Bertoncello I, 1993, 'Delayed hematopoietic development in osteopetrotic (op/op) mice', Journal of Experimental Medicine, vol. 177, no. 1, pp. 237 - 242 BEGG SK; RADLEY JM; POLLARD JW; CHISHOLM O; STANLEY ER; BERTONCELLO I, 1992, 'MACROPHAGE DEVELOPMENT, AND AGE-RELATED-CHANGES IN HEMATOPOIESIS, IN CSF-1 DEFICIENT OSTEOPETROTIC (OP/OP) MICE', Experimental Hematology, vol. 20, no. 6, pp. 826 - 826, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1992JA73400461&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a Chisholm O; Stapleton P; Symonds G, 1992, 'Constitutive expression of exogenous myc in myelomonocytic cells: Acquisition of a more transformed phenotype and inhibition of differentiation induction', Oncogene, vol. 7, no. 9, pp. 1827 - 1836 Chisholm O; Symonds G, 1992, 'An in vitro fibroblast model system to study myc-driven tumour progression', International Journal of Cancer, vol. 51, no. 1, pp. 149 - 158, http://dx.doi.org/10.1002/ijc.2910510126 Bonham L; Kwok J; Chisholm O; Symonds G, 1991, 'Inducible transformation of fibroblasts using a metallothionein-v-myc gene construct', Oncogene, vol. 6, no. 6, pp. 1073 - 1077