Cederholm, Jennie - University of New South Wales

个人简介

I have a MSc in Medical Biology from Linkoping University, Linkoping, Sweden, and a PhD in Biomedial Sciences from the University of South Australia, Adelaide. My PhD involved studying the human skeletal muscle chloride ion channel, ClC-1. My main interest was in the gating mechanism of this ion channel, and for this I utilised molecular biology to create mutant channels and investigate their function using whole-cell patch clamping. My first post-doctoral position was at Neuroscience Research Australia, Sydney, in the laboratory of Professor Peter Schofield. During this time, I also held a conjoint position at UNSW, working with Dr Trevor Lewis in the Membrane Biophysics laboratory. Here I investigated the importance of loop structures in the glycine receptor, again using molecular biology and the whole-cell patch clamp technique. I also created several glycine receptor homology models using molecular modelling. I am currently working with Professor Gary Housley, at the Translational Neuroscience Facility (TNF), on hearing adaptation to sustained noise, with focus being on the role of P2X2 receptors in noise-induced hearing loss. My teaching involves facilitation of Medicine undergraduates in Phase 1, and also lecturing/tutoring/demonstrating of Medicine and Science undergraduates in the subject of Physiology. I represent Early Career Academics (ECAs) in the School and Faculty, respectively, on the SoMS Research Support Committee and the UNSW Early Career Academic Network Executive Committee (ECAN-EC). As part of my role as an inaugural member of the ECAN-EC, I am committed to engaging with career development concerns of ECAs. I am also a member of the UNSW Academic Board.

研究领域

Neurosciences

近期论文

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Froud KE; Wong ACY; Cederholm JME; Klugmann M; Sandow SL; Julien JP; Ryan AF; Housley GD, 2015, 'Type II spiral ganglion afferent neurons drive medial olivocochlear reflex suppression of the cochlear amplifier', Nature Communications, vol. 6, http://dx.doi.org/10.1038/ncomms8115 Housley GD; Morton-Jones R; Vlajkovic SM; Telang RS; Paramananthasivam V; Tadros SF; Wong AY; Froud KE; Cederholm JME; Sivakumaran Y; Snguanwongchai P; Khakh BS; Cockayne DA; Thorne PR; Ryan AF, 2013, 'ATP-gated ion channels mediate adaptation to elevated sound levels', Proceedings of the National Academy of Sciences of USA, vol. 110, no. 18, pp. 7494 - 7499, http://dx.doi.org/10.1073/pnas.1222295110 Cederholm JME; Froud KE; Wong ACY; Ko M; Ryan AF; Housley GD, 2012, 'Differential actions of isoflurane and ketamine-based anaesthetics on cochlear function in the mouse', Hearing Research, vol. 292, no. 1-2, pp. 71 - 79, http://dx.doi.org/10.1016/j.heares.2012.08.010 Cederholm JM; Rychkov GY; Bagley CJ; Bretag AH, 2010, 'Inter-subunit communication and fast gate integrity are important for common gating in hClC-1', The International Journal of Biochemistry and Cell Biology, vol. 42, no. 7, pp. 1182 - 1188, http://dx.doi.org/10.1016/j.biocel.2010.04.004 Cederholm JME; Absalom NL; Sugiharto S; Griffith R; Schofield PR; Lewis TM, 2010, 'Conformational changes in extracellular loop 2 associated with signal transduction in the glycine receptor', Journal of Neurochemistry, vol. 115, no. 5, pp. 1245 - 1255, http://dx.doi.org/10.1111/j.1471-4159.2010.07021.x Cederholm JME; Schofield PR; Lewis TM, 2009, 'Gating mechanisms in Cys-loop receptors', European Biophysics Journal, vol. 39, no. 1, pp. 37 - 49, http://dx.doi.org/10.1007/s00249-009-0452-y