Bull, Rowena - University of New South Wales

个人简介

I am an early career researcher studying viral evolution of RNA viruses, in particular, hepatitis C virus, norovirus and influenza. I have been investigating the viral and host factors that different RNA viruses use to generate diversity and maintain their survival in the population. We take an interdisciplinary approach involving cutting edge virological, immunological and bioinformatic techniques. Our contribution to virology ranges from the development of virological in vitro based fitness assays, viral gene expression studies, molecular epidemiology, evolutionary analysis of adaptive immune responses against RNA viruses, and bioinformatics. A recent research focus has been the analysis of over 30 million nucleotides generated through next generation sequencing approaches in a longitudinal study of ten HCV infected patients (Bull, Luciani et al. PLoS pathogens 2011).

研究领域

Within-host evolutionary dynamics of RNA viruses including HCV, influenza, and NoV Investigating the selective pressures of cellular and humoral immune responses against HCV

近期论文

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Walker MR; Li H; Teutsch S; Betz-Stablein B; Luciani F; Lloyd AR; Bull RA, 2016, 'Incident hepatitis c virus genotype distribution and multiple infection in australian prisons', Journal of Clinical Microbiology, vol. 54, no. 7, pp. 1855 - 1861, http://dx.doi.org/10.1128/JCM.00287-16 Bull RA; Eltahla AA; Rodrigo C; Koekkoek SM; Walker M; Pirozyan MR; Betz-Stablein B; Toepfer A; Laird M; Oh S; Heiner C; Maher L; Schinkel J; Lloyd AR; Luciani F, 2016, 'A method for near full-length amplification and sequencing for six hepatitis C virus genotypes', BMC Genomics, vol. 17, no. 1, http://dx.doi.org/10.1186/s12864-016-2575-8 Eltahla AA; Rizzetto S; Pirozyan MR; Betz-Stablein BD; Venturi V; Kedzierska K; Lloyd AR; Bull RA; Luciani F, 2016, 'Linking the T cell receptor to the single cell transcriptome in antigen-specific human T cells', Immunology and Cell Biology, vol. 94, no. 6, pp. 604 - 611, http://dx.doi.org/10.1038/icb.2016.16 Bartlett SR; Jacka B; Bull RA; Luciani F; Matthews GV; Lamoury FMJ; Hellard ME; Hajarizadeh B; Teutsch S; White B; Maher L; Dore GJ; Lloyd AR; Grebely J; Applegate TL, 2016, 'HIV infection and hepatitis C virus genotype 1a are associated with phylogenetic clustering among people with recently acquired hepatitis C virus infection', Infection, Genetics and Evolution, vol. 37, pp. 252 - 258, http://dx.doi.org/10.1016/j.meegid.2015.11.028 Narayana SK; Helbig KJ; McCartney EM; Eyre NS; Bull RA; Eltahla A; Lloyd AR; Beard MR, 2015, 'The interferon-induced transmembrane proteins, IFITM1, IFITM2, and IFITM3 inhibit hepatitis C virus entry', Journal of Biological Chemistry, vol. 290, no. 43, pp. 25946 - 25959, http://dx.doi.org/10.1074/jbc.M115.657346 Eltahla AA; Luciani F; White PA; Lloyd AR; Bull RA, 2015, 'Inhibitors of the hepatitis C virus polymerase; mode of action and resistance', Viruses, vol. 7, no. 10, pp. 5206 - 5224, http://dx.doi.org/10.3390/v7102868 Lamoury FMJ; Jacka B; Bartlett S; Bull RA; Wong A; Amin J; Schinkel J; Poon AF; Matthews GV; Grebely J; Dore GJ; Applegate TL, 2015, 'The influence of hepatitis C virus genetic region on phylogenetic clustering analysis', PLoS One, vol. 10, no. 7, http://dx.doi.org/10.1371/journal.pone.0131437 Bretaña NA; Boelen L; Bull R; Teutsch S; White PA; Lloyd AR; Luciani F; HITS-p investigators, 2015, 'Transmission of Hepatitis C Virus among Prisoners, Australia, 2005-2012.', Emerging Infectious Diseases, vol. 21, no. 5, pp. 765 - 774, http://dx.doi.org/10.3201/eid2105.141832 Bull RA; Leung P; Gaudieri S; Deshpande P; Cameron B; Walker M; Chopra A; Lloyd AR; Luciani F; Dolan K; Haber P; Rawlinson W; Treloar C; Dore G; Maher L, 2015, 'Transmitted/founder viruses rapidly escape from CD8⁺ T cell responses in acute hepatitis C virus infection', Journal of Virology, vol. 89, no. 10, pp. 5478 - 5490, http://dx.doi.org/10.1128/JVI.03717-14 Mina MM; Luciani F; Cameron B; Bull RA; Beard MR; Booth D; Lloyd AR, 2015, 'Resistance to hepatitis C virus: Potential genetic and immunological determinants', Lancet Infectious Diseases, http://dx.doi.org/10.1016/S1473-3099(14)70965-X Leung P; Bull R; Lloyd A; Luciani F, 2014, 'A bioinformatics pipeline for the analyses of viral escape dynamics and host immune responses during an infection', BioMed Research International, vol. 2014, http://dx.doi.org/10.1155/2014/264519 Hartfield M; Bull R; White PA; Lloyd A; Luciani F; Alizon S, 2014, 'Evidence that hepatitis C virus genome partly controls infection outcome', Evolutionary Applications: evolutionary approaches to environmental, biomedical and socio-economic issues, vol. 7, no. 5, pp. 533 - 547, http://dx.doi.org/10.1111/eva.12151 Töpfer A; Marschall T; Bull RA; Luciani F; Schönhuth A; Beerenwinkel N, 2014, 'Viral quasispecies assembly via maximal clique enumeration', Lecture Notes in Computer Science, vol. 8394 LNBI, pp. 309 - 310, http://dx.doi.org/10.1007/978-3-319-05269-4-25 Wong KKY; Rockman S; Ong C; Bull R; Stelzer-Braid S; Rawlinson W, 2013, 'Comparison of influenza virus replication fidelity in vitro using selection pressure with monoclonal antibodies', Journal of Medical Virology, vol. 85, no. 6, pp. 1090 - 1094, http://dx.doi.org/10.1002/jmv.23532 Sugden PB; Ratnarajah S; Cameron B; Bull R; Lloyd AR; Pham TNQ; Michalak TI; White PA, 2013, 'Rare occurrence of occult hepatitis C virus in apparently uninfected injecting drug users: A two-centre, masked, case-control study', Journal of Viral Hepatitis, http://dx.doi.org/10.1111/jvh.12098 Sugden PB; Cameron B; Bull R; White PA; Lloyd AR, 2012, 'Occult infection with hepatitis C virus: Friend or foe', Immunology and Cell Biology, vol. 90, no. 8, pp. 763 - 773, http://dx.doi.org/10.1038/icb.2012.20 Bull RA; Eden JS; Luciani F; McElroy K; Rawlinson WD; White PA, 2012, 'Contribution of intra- and interhost dynamics to norovirus evolution', Journal of Virology, vol. 86, no. 6, pp. 3219 - 3229, http://dx.doi.org/10.1128/JVI.06712-11 Grebely J; Pham ST; Matthews GV; Petoumenos K; Bull RA; Yeung B; Rawlinson W; Kaldor J; Lloyd A; Hellard M; Dore GJ; White PA, 2012, 'Hepatitis C virus reinfection and superinfection among treated and untreated participants with recent infection', Hepatology, vol. 55, no. 4, pp. 1058 - 1069, http://dx.doi.org/10.1002/hep.24754 Gouklani H; Bull RA; Beyer C; Coulibaly F; Gowans EJ; Drummer HE; Netter HJ; White PA; Haqshenas G, 2012, 'Hepatitis C virus nonstructural protein 5B is involved in virus morphogenesis', Journal of Virology, vol. 86, no. 9, pp. 5080 - 5088, http://dx.doi.org/10.1128/JVI.07089-11 Luciani F; Bull RA; Lloyd AR, 2012, 'Next generation deep sequencing and vaccine design: Today and tomorrow', Trends in Biotechnology, vol. 30, no. 9, pp. 443 - 452, http://dx.doi.org/10.1016/j.tibtech.2012.05.005