Biro, Maté - University of New South Wales - School of Medical Sciences

个人简介

Dr Maté Biro received his PhD with summa cum laudeat the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany. Dr. Biro has previously worked at the Centenary Institute of Cancer Medicine and Cell Biology in Sydney, in the Imaging Informatics division at the Bioinformatics Institute of A*STAR in Singapore, at the MIT BioImaging Center in Cambridge, MA, USA and in the Belle collaboration at the KEK: High Energy Accelerator Research Organisation in Tsukuba, Japan. As an EMBL Australia Group Leader he will expand his exciting studies on the way actomyosin complexes control cell shape, homeostasis and migration in cancer and immune function, focusing on the elucidation of biomechanical interaction within and between cells. Dr. Biro is spearheading the use of complex in vitro and in vivo models for studying the cell-intrinsic actin cytoskeleton cues and dynamics that govern the invasive migration of tumour cells, the tissue scanning of T cells and their cytotoxic interaction with tumour cells. Using a multidisciplinary approach encompassing cell biology, biophysics, bioimage informatics and advanced light microscopy, he aims to unravel fundamental actin-based processes and develop new methodologies for basic cell biological research. Dr. Biro's research relies heavily on advanced microscopy and the development of image analysis platforms capable of automatically detecting and analysing the kinetics of actomyosin, cell movement and protrusions. Dr. Biro's group is primarily concerned with the cell biology and mechanics of the actin cytoskeleton, and how immune cells (T cells) locate and kill cancer cells.

研究领域

How the T cell cytoskeleton drives the scanning for and interactions with tumour cells Migratory scanning of T cells Image and quantitate the intricate dynamics and interactions of actin

近期论文

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Tay SS; Carol H; Biro M, 2016, 'TriKEs and BiKEs join CARs on the cancer immunotherapy highway', Human Vaccines and Immunotherapeutics, pp. 1 - 7, http://dx.doi.org/10.1080/21645515.2016.1198455 Galeano Niño JL; Kwan RYQ; Weninger W; Biro M, 2016, 'Antigen-specific T cells fully conserve antitumour function following cryopreservation', Immunology and Cell Biology, vol. 94, no. 4, pp. 411 - 418, http://dx.doi.org/10.1038/icb.2015.105 Sedzinski J; Hannezo E; Tu F; Biro M; Wallingford JB, 2016, 'Emergence of an Apical Epithelial Cell Surface In Vivo', Developmental Cell, vol. 36, no. 1, pp. 24 - 35, http://dx.doi.org/10.1016/j.devcel.2015.12.013 Tong PL; Roediger B; Kolesnikoff N; Biro M; Tay SS; Jain R; Shaw LE; Grimbaldeston MA; Weninger W, 2015, 'The skin immune atlas: Three-dimensional analysis of cutaneous leukocyte subsets by multiphoton microscopy', Journal of Investigative Dermatology, vol. 135, no. 1, pp. 84 - 93, http://dx.doi.org/10.1038/jid.2014.289 Newman P; Lu Z; Roohani-Esfahani SI; Church TL; Biro M; Davies B; King A; Mackenzie K; Minett AI; Zreiqat H, 2015, 'Porous and strong three-dimensional carbon nanotube coated ceramic scaffolds for tissue engineering', Journal of Materials Chemistry B, vol. 3, no. 42, pp. 8337 - 8347, http://dx.doi.org/10.1039/c5tb01052g Weninger W; Biro M; Jain R, 2014, 'Leukocyte migration in the interstitial space of non-lymphoid organs', Nature Reviews Immunology, vol. 14, no. 4, pp. 232 - 246, http://dx.doi.org/10.1038/nri3641 Munoz MA; Biro M; Weninger W, 2014, 'T cell migration in intact lymph nodes in vivo', Current Opinion in Cell Biology, vol. 30, no. 1, pp. 17 - 24, http://dx.doi.org/10.1016/j.ceb.2014.05.002 Bovellan M; Romeo Y; Biro M; Boden A; Chugh P; Yonis A; Vaghela M; Fritzsche M; Moulding D; Thorogate R; Jégou A; Thrasher AJ; Romet-Lemonne G; Roux PP; Paluch EK; Charras G, 2014, 'Cellular control of cortical actin nucleation', Current Biology, vol. 24, no. 14, pp. 1628 - 1635, http://dx.doi.org/10.1016/j.cub.2014.05.069 Biro M; Munoz MA; Weninger W, 2014, 'Targeting Rho-GTPases in immune cell migration and inflammation', British Journal of Pharmacology, vol. 171, no. 24, pp. 5491 - 5506, http://dx.doi.org/10.1111/bph.12658 Biro M; Romeo Y; Kroschwald S; Bovellan M; Boden A; Tcherkezian J; Roux PP; Charras G; Paluch EK, 2013, 'Cell cortex composition and homeostasis resolved by integrating proteomics and quantitative imaging', Cytoskeleton, vol. 70, no. 11, pp. 741 - 754, http://dx.doi.org/10.1002/cm.21142 Sedzinski J; Biro M; Oswald A; Tinevez JY; Salbreux G; Paluch E, 2011, 'Polar actomyosin contractility destabilizes the position of the cytokinetic furrow', Nature, vol. 476, no. 7361, pp. 462 - 468, http://dx.doi.org/10.1038/nature10286 Puah WC; Cheok LP; Biro M; Ng WT; Wasser M, 2011, 'TLM-converter: Reorganization of long time-lapse microscopy datasets for downstream image analysis', BioTechniques: the journal of laboratory technology for bioresearch, vol. 51, no. 1, pp. 49 - 54, http://dx.doi.org/10.2144/000113704 Biro M; Kroschwald S; Paluch E, 2010, 'Analysis of De Novo Cell Cortex Assembly in Blebs as a Novel Assay for Probing Cortical Dynamics and Regulation', Biophysical Journal, vol. 98, no. 3, pp. 159a - 159a, http://dx.doi.org/10.1016/j.bpj.2009.12.853