Zhang, Li - University of New South Wales - School of Biotechnology and Biomolecular Science

个人简介

Education MBBS, Fudan University (Former Shanghai Medical University) China PhD, University of Cambridge UK Professional Experience 2008-current: Senior Lecturer, School of BABS 2007-2008: Lecturer/Senior Research Associate, School of BABS Post-Doctoral Fellow, Dept of Immunology, UNSW Post-Doctoral Fellow, Institute of Molecular and Cell Biology, Singapore Medical Resident, China-Japan Hospital, China

研究领域

Dr Li Zhang’s group has conducted pioneering research in understanding the role of oral Campylobacter species such as Campylobacter concisus in initiating extra-oral chronic human diseases. Dr Zhang and other researchers reported an association between C. concisus and inflammatory bowel disease (IBD). Following this, Dr Zhang hypothesized that some oral C. concisus strains have enteric pathogenicity and are initiators of a subgroup of human IBD. Studies in Dr Zhang’s group in the past a number of years have provided information that is fundamental to this emerging research field. Dr Zhang’s group identified C. concisus prophage CON_phi2, which contains the zonula occludens toxin (zot) gene. They have characterised the expression and release of Zot toxin from C. concisus, as well as the biological activities of C. concisus zot on intestinal epithelial barrier and the immune system. They found that a specific polymorphic C. concisus zot is associated with patients with active IBD.

近期论文

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Mahendran V; Liu F; Riordan SM; Grimm MC; Tanaka MM; Zhang L, 2016, 'Examination of the effects of Campylobacter concisus zonula occludens toxin on intestinal epithelial cells and macrophages.', Gut Pathogens, vol. 8, pp. 18, http://dx.doi.org/10.1186/s13099-016-0101-9 Zhang L, 2015, 'Oral Campylobacter species: Initiators of a subgroup of inflammatory bowel disease?', World Journal of Gastroenterology, vol. 21, no. 31, pp. 9239 - 9244, http://dx.doi.org/10.3748/wjg.v21.i31.9239 Mahendran V; Octavia S; Demirbas OF; Sabrina S; Ma R; Lan R; Riordan SM; Grimm MC; Zhang L, 2015, 'Delineation of genetic relatedness and population structure of oral and enteric Campylobacter concisus strains by analysis of housekeeping genes', Microbiology, vol. 161, no. 8, pp. 1600 - 1612, http://dx.doi.org/10.1099/mic.0.000112 Ma R; Sapwell N; Chung HKL; Lee H; Mahendran V; Leong RW; Riordan SM; Grimm MC; Zhang L, 2015, 'Investigation of the effects of ph and bile on the growth of oral campylobacter concisus strains isolated from patients with inflammatory bowel disease and controls', Journal of Medical Microbiology, vol. 64, no. 4, pp. 438 - 445, http://dx.doi.org/10.1099/jmm.0.000013 Lee H; Liu F; Mahendran V; Zhang L, 2014, 'Detection of the zonula occludens toxin expressed in Campylobacter concisus strains', Journal of Gastroenterology and Hepatology, vol. 29, pp. 10 - 10, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000343863000019&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a Lee H; Ma R; Grimm MC; Riordan SM; Lan R; Zhong L; Raftery M; Zhang L, 2014, 'Examination of the anaerobic growth of Campylobacter concisus strains', International Journal of Microbiology, vol. 2014, http://dx.doi.org/10.1155/2014/476047 Zhang L; Lee H; Grimm MC; Riordan SM; Day AS; Lemberg DA, 2014, 'Campylobacter concisus and inflammatory bowel disease', World Journal of Gastroenterology, vol. 20, no. 5, pp. 1259 - 1267, http://dx.doi.org/10.3748/wjg.v20.i5.1259 Mahendran V; Tan YS; Riordan SM; Grimm MC; Day AS; Lemberg DA; Octavia S; Lan R; Zhang L, 2013, 'The Prevalence and Polymorphisms of Zonula Occluden Toxin Gene in Multiple Campylobacter concisus Strains Isolated from Saliva of Patients with Inflammatory Bowel Disease and Controls', PLoS One, vol. 8, no. 9, http://dx.doi.org/10.1371/journal.pone.0075525 Hallab JC; Leach ST; Zhang L; Mitchell HM; Oei J; Lui K; Day AS, 2013, 'Molecular characterization of bacterial colonization in the preterm and term infant's intestine', Indian Journal of Pediatrics, vol. 80, no. 1, pp. 1 - 5, http://dx.doi.org/10.1007/s12098-012-0753-5 Ismail Y; Lee H; Riordan SM; Grimm MC; Zhang L, 2013, 'The Effects of Oral and Enteric Campylobacter concisus Strains on Expression of TLR4, MD-2, TLR2, TLR5 and COX-2 in HT-29 Cells', PLoS One, vol. 8, no. 2, http://dx.doi.org/10.1371/journal.pone.0056888 Ismail Y; Mahendran V; Octavia S; Day AS; Riordan SM; Grimm MC; Lan R; Lemberg D; Tran TAT; Zhang L, 2012, 'Investigation of the enteric pathogenic potential of oral Campylobacter concisus strains isolated from patients with inflammatory bowel disease', PLoS One, vol. 7, no. 5, http://dx.doi.org/10.1371/journal.pone.0038217 Mahendran V; Riordan SM; Grimm MC; Tran TAT; Major J; Kaakoush NO; Mitchell H; Zhang L, 2011, 'Prevalence of Campylobacter species in adult Crohn's disease and the preferential colonization sites of Campylobacter species in the human intestine', PLoS One, vol. 6, no. 9, http://dx.doi.org/10.1371/journal.pone.0025417 Kovach Z; Kaakoush NO; Lamb S; Zhang L; Raftery MJ; Mitchell H, 2011, 'Immunoreactive proteins of Campylobacter concisus, an emergent intestinal pathogen', FEMS Immunology and Medical Microbiology, vol. 63, no. 3, pp. 387 - 396, http://dx.doi.org/10.1111/j.1574-695X.2011.00864.x Mitchell HM; Man SM; Leach S; Nahidi L; Norman J; Day AS; Zhang L; Tan S; Kaakoush NO, 2010, 'Campylobacter concisus: an emergent intestinal pathogen', Journal of Gastroenterology and Hepatology, vol. 25, pp. A82 - A82, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000283321200223&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a Wong SM; Day A; Lemberg D; Riordan S; Grimm MC; Budiman V; Mitchell H; Ismail Y; Zhang L, 2010, 'Antibiotic susceptibility of Campylobacter concisus isolated from patients with inflammatory bowel disease', Journal of Gastroenterology and Hepatology, vol. 25, pp. A80 - A80, http://dx.doi.org/10.1111/j.1440-1746.2010.06454.x Man SM; Zhang L; Day AS; Leach ST; Lemberg DA; Mitchell H, 2010, 'Campylobacter concisus and other Campylobacter species in children with newly diagnosed Crohn's disease', Inflammatory Bowel Diseases, vol. 16, no. 6, pp. 1008 - 1016, http://dx.doi.org/10.1002/ibd.21157 Zhang L; Budiman V; Day AS; Mitchell H; Lemberg DA; Riordan SM; Grimm M; Leach ST; Ismail Y, 2010, 'Isolation and detection of Campylobacter concisus from saliva of healthy individuals and patients with inflammatory bowel disease', Journal of Clinical Microbiology, vol. 48, no. 8, pp. 2965 - 2967, http://dx.doi.org/10.1128/JCM.02391-09 Kaakoush NO; Holmes J; Octavia S; Man SM; Zhang L; Castaño-Rodríguez N; Day AS; Leach ST; Lemberg DA; Dutt S; Stormon M; O'Loughlin EV; Magoffin A; Mitchell H, 2010, 'Detection of Helicobacteraceae in Intestinal Biopsies of Children with Crohn's Disease', Helicobacter (Oxford), vol. 15, no. 6, pp. 549 - 557, http://dx.doi.org/10.1111/j.1523-5378.2010.00792.x Man SM; Kaakoush NO; Leach ST; Nahidi L; Lu HK; Norman J; Day AS; Zhang L; Mitchell HM, 2010, 'Host attachment, invasion, and stimulation of proinflammatory cytokines by campylobacter concisus and other non-campylobacter jejuni Campylobacter species', Journal of Infectious Diseases, vol. 202, no. 12, pp. 1855 - 1865, http://dx.doi.org/10.1086/657316 Guslandi M; Zhang L; Man SM; Day AS; Leach ST; Lemberg DA; Dutt S; Stormon M; Otley A; O'Loughlin EV; Magoffin A; Ng PHY; Mitchell H, 2009, 'Campylobacter concisus: a New Character in the Crohn's Disease Story?', Journal of Clinical Microbiology, vol. 47, no. 5, pp. 1614 - 1615, http://dx.doi.org/10.1128/JCM.00310-09