Wilkins, Marc - University of New South Wales - School of Biotechnology and Biomolecular Science

个人简介

2005-current: Professor, School of BABS 2011-current: Director, Ramaciotti Centre for Gene Function Analysis 2008-current: Director, NSW Systems Biology Initiative 2004: Head of Proteomics, Proteome Systems Limited 1999: Vice President Bioinformatics, Proteome Systems Limited

研究领域

In 1994, Marc Wilkins developed the concept of the proteome and coined the term. In 1997 he co-wrote and co-edited the first book on proteomics (4,000+ copies sold). This, and a series of other seminal works, substantially contributed to the establishment of the proteome and of proteome research. Proteomics is the most widely adopted of the new -omics, is now included in biochemistry textbooks and the undergraduate curriculum. Marc has published >100 peer-reviewed research papers, review papers and book chapters and has edited 2 books. Marc's research has tackled many of the key issues in proteomics. A particular strength has been the capacity to combine large-scale analytical techniques with complex bioinformatics to open new avenues for biological investigation. Current research interests are (i) the role of protein methylation in the proteome (ii) the dynamics of protein interaction networks and (iii) the analysis of next-generation sequencing data. Marc directs two centres at UNSW: the NSW Systems Biology Initiative (http://www.systemsbiology.org.au/) and the Ramaciotti Centre for Gene Function Analysis (http://www.ramaciotti.unsw.edu.au/). These centres are funded by NCRIS, EIF Super Science, ARC LIEF and the NSW State Government Science Leveraging Fund. Marc co-founded Proteome Systems Pty Ltd in 1999. Recently renamed to Tyrian Diagnostics, this proteomic diagnostics company is listed on the Australian Securities Exchange and has developed technology for rapid point-of-care diagnostic testing . Marc is also a co-founder and non-executive Director of Regeneus Pty Ltd, a privately held regenerative medicine company which uses autologous adult stem cells to treat a range of musculoskeletal disorders.

近期论文

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Lai YW; Campbell LT; Wilkins MR; Pang CN; Chen S; Carter DA, 2016, 'Synergy and antagonism between iron chelators and antifungal drugs in Cryptococcus.', International Journal of Antimicrobial Agents, http://dx.doi.org/10.1016/j.ijantimicag.2016.06.012 Corley SM; Canales CP; Carmona-Mora P; Mendoza-Reinosa V; Beverdam A; Hardeman EC; Wilkins MR; Palmer SJ, 2016, 'RNA-Seq analysis of Gtf2ird1 knockout epidermal tissue provides potential insights into molecular mechanisms underpinning Williams-Beuren syndrome', BMC Genomics, vol. 17, no. 1, http://dx.doi.org/10.1186/s12864-016-2801-4 Hart-Smith G; Yagoub D; Tay AP; Pickford R; Wilkins MR, 2016, 'Large scale mass spectrometry-based identifications of enzyme-mediated protein methylation are subject to high false discovery rates', Molecular and Cellular Proteomics, vol. 15, no. 3, pp. 989 - 1006, http://dx.doi.org/10.1074/mcp.M115.055384 Low JKK; Im H; Erce MA; Hart-Smith G; Snyder MP; Wilkins MR, 2016, 'Protein substrates of the arginine methyltransferase Hmt1 identified by proteome arrays', Proteomics, vol. 16, no. 3, pp. 465 - 476, http://dx.doi.org/10.1002/pmic.201400564 Hamey JJ; Winter DL; Yagoub D; Overall CM; Hart-Smith G; Wilkins MR, 2016, 'Novel N-terminal and lysine methyltransferases that target translation elongation factor 1A in yeast and human', Molecular and Cellular Proteomics, vol. 15, no. 1, pp. 164 - 176, http://dx.doi.org/10.1074/mcp.M115.052449 Taha; Siddiqui KS; Campanaro S; Najnin T; Deshpande N; Williams TJ; Aldrich-Wright J; Wilkins M; Curmi P; Cavicchioli R, 2016, 'Single TRAM domain RNA-binding proteins in Archaea: functional insight from Ctr3 from the Antarctic methanogen Methanococcoides burtonii.', Environmental Microbiology, http://dx.doi.org/10.1111/1462-2920.13229 Reis RS; Hart-Smith G; Eamens AL; Wilkins MR; Waterhouse PM, 2015, 'Gene regulation by translational inhibition is determined by Dicer partnering proteins.', Nature Plants, vol. 1, pp. 14027, http://dx.doi.org/10.1038/nplants.2014.27 Reis RS; Hart-Smith G; Eamens AL; Wilkins MR; Waterhouse PM, 2015, 'MicroRNA regulatory mechanisms play different roles in arabidopsis', Journal of Proteome Research, vol. 14, no. 11, pp. 4743 - 4751, http://dx.doi.org/10.1021/acs.jproteome.5b00616 Shum AMY; Fung DCY; Corley SM; McGill MC; Bentley NL; Tan TC; Wilkins MR; Polly P, 2015, 'Cardiac and skeletal muscles show molecularly distinct responses to cancer cachexia', Physiological Genomics, vol. 47, no. 12, pp. 588 - 599, http://dx.doi.org/10.1152/physiolgenomics.00128.2014 Deshpande NP; Wilkins MR; Mitchell HM; Kaakoush NO, 2015, 'Novel genetic markers define a subgroup of pathogenic Escherichia coli strains belonging to the B2 phylogenetic group', FEMS Microbiology Letters, vol. 362, no. 22, http://dx.doi.org/10.1093/femsle/fnv193 Yagoub D; Tay AP; Chen Z; Hamey JJ; Cai C; Chia SZ; Hart-Smith G; Wilkins MR, 2015, 'Proteogenomic Discovery of a Small, Novel Protein in Yeast Reveals a Strategy for the Detection of Unannotated Short Open Reading Frames', Journal of Proteome Research, vol. 14, no. 12, pp. 5038 - 5047, http://dx.doi.org/10.1021/acs.jproteome.5b00734 Tay AP; Pang CNI; Twine NA; Hart-Smith G; Harkness L; Kassem M; Wilkins MR, 2015, 'Proteomic validation of transcript isoforms, including those assembled from RNA-Seq data', Journal of Proteome Research, vol. 14, no. 9, pp. 3541 - 3554, http://dx.doi.org/10.1021/pr5011394 Harkness L; Twine NA; Abu Dawud R; Jafari A; Aldahmash A; Wilkins MR; Adjaye J; Kassem M, 2015, 'Molecular characterisation of stromal populations derived from human embryonic stem cells: Similarities to immortalised bone marrow derived stromal stem cells', Bone Reports, vol. 3, pp. 32 - 39, http://dx.doi.org/10.1016/j.bonr.2015.07.002 Yagoub D; Hart-Smith G; Moecking J; Erce MA; Wilkins MR, 2015, 'Yeast proteins Gar1p, Nop1p, Npl3p, Nsr1p, and Rps2p are natively methylated and are substrates of the arginine methyltransferase Hmt1p', Proteomics, http://dx.doi.org/10.1002/pmic.201500075 Nahidi L; Corley SM; Wilkins MR; Wei J; Alhagamhmad M; Day AS; Lemberg DA; Leach ST, 2015, 'The major pathway by which polymeric formula reduces inflammation in intestinal epithelial cells: a microarray-based analysis', Genes and Nutrition, vol. 10, no. 5, http://dx.doi.org/10.1007/s12263-015-0479-x Yap JYS; Rohner T; Greenfield A; Van Der Merwe M; McPherson H; Glenn W; Kornfeld G; Marendy E; Pan AYH; Wilton A; Wilkins MR; Rossetto M; Delaney SK, 2015, 'Complete chloroplast genome of the Wollemi pine (Wollemia nobilis): Structure and evolution', PLoS One, vol. 10, no. 6, http://dx.doi.org/10.1371/journal.pone.0128126 Winter DL; Abeygunawardena D; Hart-Smith G; Erce MA; Wilkins MR, 2015, 'Lysine methylation modulates the protein-protein interactions of yeast cytochrome C Cyc1p', Proteomics, http://dx.doi.org/10.1002/pmic.201400521 Kaakoush NO; Deshpande NP; Man SM; Burgos-Portugal JA; Khattak FA; Raftery MJ; Wilkins MR; Mitchell HM, 2015, 'Transcriptomic and proteomic analyses reveal key innate immune signatures in the host response to the gastrointestinal pathogen Campylobacter concisus', Infection and Immunity, vol. 83, no. 2, pp. 832 - 845, http://dx.doi.org/10.1128/IAI.03012-14 Gilchrist AS; Shearman DCA; Frommer M; Raphael KA; Deshpande NP; Wilkins MR; Sherwin WB; Sved JA, 2014, 'The draft genome of the pest tephritid fruit fly Bactrocera tryoni: Resources for the genomic analysis of hybridising species', BMC Genomics, pp. 1 - 17, http://dx.doi.org/10.1186/1471-2164-15-1153 Hook SE; Osborn HL; Gissi F; Moncuquet P; Twine NA; Wilkins MR; Adams MS, 2014, 'RNA-Seq analysis of the toxicant-induced transcriptome of the marine diatom, Ceratoneis closterium', Marine Genomics, vol. 16, no. 1, pp. 45 - 53, http://dx.doi.org/10.1016/j.margen.2013.12.004