Voineagu, Irina - University of New South Wales - School of Biotechnology and Biomolecular Science

个人简介

2001-2012: Research Scientist, RIKEN Omics Science Center, Japan 2008-2011: Postdoctoral Researcher, Dept of Neurogenetics, University of California, LA 2003-2008: PhD Biochemistry and Molecular Genetics, University of Illinois, Chicago 1996-2002: MD, Carol Davila University, Bucharest, Romania

研究领域

Broadly, my research interests are in the area of molecular genetic mechanisms underlying human brain disorders. During my PhD at the University of Illinois in Chicago, I studied the role of DNA replication in trinucleotide repeat expansions, a form of genomic instability responsible for multiple neurodegenerative and neurodevelopmental disorders. Trinucleotide repeats, such as (CGG)n, (GAA)n, (CAG)n, have the common property to increase in length when transmitted from parents to offspring, a phenomenon mediated by DNA replication and recombination defects. My PhD work demonstrated that unstable DNA repeats block replication fork progression in bacteria, yeast and mammalian cells by forming DNA-hairpins on the lagging strand (Voineagu et al. PNAS 2008), and investigated for the first time the cellular checkpoint responses to replication fork arrest at CGG repeats. This work led to a novel model of chromosomal fragility at CGG repeat sequences (Voineagu et al. Nature Struct. Mol. Biol 2009). For postdoctoral research, I joined the Neurogenetics Department at UCLA, to investigate the molecular mechanisms of autism and intellectual disability, using transcriptome methods. My postdoctoral work led to the identification of a novel gene implicated in X-linked intellectual disability (Voineagu et al., Mol. Psychiatry 2011) and the characterisation of shared molecular pathways in autism post-mortem brain tissue (Voineagu et al. Nature 2011).

近期论文

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Yao P; Lin P; Gokoolparsadh A; Assareh A; Thang MWC; Voineagu I, 2015, 'Coexpression networks identify brain region-specific enhancer RNAs in the human brain', Nature Neuroscience, vol. 18, no. 8, pp. 1168 - 1174, http://dx.doi.org/10.1038/nn.4063 Tian Y; Voineagu I; Paşca SP; Won H; Chandran V; Horvath S; Dolmetsch RE; Geschwind DH, 2014, 'Alteration in basal and depolarization induced transcriptional network in iPSC derived neurons from Timothy syndrome', Genome Medicine: medicine in the post-genomic era, vol. 6, no. 10, http://dx.doi.org/10.1186/s13073-014-0075-5 Fort A; Hashimoto K; Yamada D; Salimullah M; Keya CA; Saxena A; Bonetti A; Voineagu I; Bertin N; Kratz A; Noro Y; Wong CH; De Hoon M; Andersson R; Sandelin A; Suzuki H; Wei CL; Koseki H; Hasegawa Y; Forrest ARR; Carninci P, 2014, 'Deep transcriptome profiling of mammalian stem cells supports a regulatory role for retrotransposons in pluripotency maintenance', Nature Genetics, vol. 46, no. 6, pp. 558 - 566, http://dx.doi.org/10.1038/ng.2965 Miyauchi S; Voineagu I, 2013, 'Autism susceptibility genes and the transcriptional landscape of the human brain', International Review of Neurobiology, vol. 113, pp. 303 - 318, http://dx.doi.org/10.1016/B978-0-12-418700-9.00010-1 Voineagu I; Eapen V, 2013, 'Converging pathways in autism spectrum disorders: Interplay between synaptic dysfunction and immune responses', Frontiers in Human Neuroscience, no. NOV, http://dx.doi.org/10.3389/fnhum.2013.00738 Voineagu I; Yoo HJ, 2013, 'Current progress and challenges in the search for autism biomarkers', Disease Markers, vol. 35, no. 1, pp. 55 - 65, http://dx.doi.org/10.1155/2013/476276 Voineagu I; Huang L; Winden K; Lazaro M; Haan E; Nelson J; McGaughran J; Nguyen LS; Friend K; Hackett A; Field M; Gecz J; Geschwind D, 2012, 'CCDC22: A novel candidate gene for syndromic X-linked intellectual disability', Molecular Psychiatry, vol. 17, no. 1, pp. 4 - 7, http://dx.doi.org/10.1038/mp.2011.95 Voineagu I, 2012, 'Gene expression studies in autism: Moving from the genome to the transcriptome and beyond', Neurobiology of Disease, vol. 45, no. 1, pp. 69 - 75, http://dx.doi.org/10.1016/j.nbd.2011.07.017 Luo R; Sanders SJ; Tian Y; Voineagu I; Huang N; Chu SH; Klei L; Cai C; Ou J; Lowe JK; Hurles ME; Devlin B; State MW; Geschwind DH, 2012, 'Genome-wide transcriptome profiling reveals the functional impact of rare de novo and recurrent CNVs in autism spectrum disorders', American Journal of Human Genetics, vol. 91, no. 1, pp. 38 - 55, http://dx.doi.org/10.1016/j.ajhg.2012.05.011 Shah KA; Shishkin AA; Voineagu I; Pavlov YI; Shcherbakova PV; Mirkin SM, 2012, 'Role of DNA Polymerases in Repeat-Mediated Genome Instability', Cell Reports, vol. 2, no. 5, pp. 1088 - 1095, http://dx.doi.org/10.1016/j.celrep.2012.10.006 Voineagu I, 2012, 'Autism: From genetics to biomarkers', Disease Markers, vol. 33, no. 5, pp. 223 - 224, http://dx.doi.org/10.3233/DMA-2012-0931 Voineagu I; Wang X; Johnston P; Lowe JK; Tian Y; Horvath S; Mill J; Cantor RM; Blencowe BJ; Geschwind DH, 2011, 'Transcriptomic analysis of autistic brain reveals convergent molecular pathology', Nature, vol. 474, no. 7351, pp. 380 - 386, http://dx.doi.org/10.1038/nature10110 Paşca SP; Portmann T; Voineagu I; Yazawa M; Shcheglovitov A; Paşca AM; Cord B; Palmer TD; Chikahisa S; Nishino S; Bernstein JA; Hallmayer J; Geschwind DH; Dolmetsch RE, 2011, 'Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome', Nature Medicine, vol. 17, no. 12, pp. 1657 - 1662, http://dx.doi.org/10.1038/nm.2576 Voineagu I; Surka CF; Shishkin AA; Krasilnikova MM; Mirkin SM, 2009, 'Replisome stalling and stabilization at CGG repeats, which are responsible for chromosomal fragility', Nature Structural and Molecular Biology, vol. 16, no. 2, pp. 226 - 228, http://dx.doi.org/10.1038/nsmb.1527 Voineagu I; Freudenreich CH; Mirkin SM, 2009, 'Checkpoint responses to unusual structures formed by DNA repeats', Molecular Carcinogenesis, vol. 48, no. 4, pp. 309 - 318, http://dx.doi.org/10.1002/mc.20512 Shishkin AA; Voineagu I; Matera R; Cherng N; Chernet BT; Krasilnikova MM; Narayanan V; Lobachev KS; Mirkin SM, 2009, 'Large-Scale Expansions of Friedreich's Ataxia GAA Repeats in Yeast', Molecular Cell, vol. 35, no. 1, pp. 82 - 92, http://dx.doi.org/10.1016/j.molcel.2009.06.017 Voineagu I; Narayanan V; Lobachev KS; Mirkin SM, 2008, 'Replication stalling at unstable inverted repeats: Interplay between DNA hairpins and fork stabilizing proteins', Proceedings of the National Academy of Sciences of USA, vol. 105, no. 29, pp. 9936 - 9941, http://dx.doi.org/10.1073/pnas.0804510105