Tanaka, Mark - University of New South Wales - School of Biotechnology and Biomolecular Science

个人简介

2016-current: Deputy Head of School/Director of Research, School of BABS 2012-current: Associate Professor, School of BABS 2007-2011: Senior Lecturer, School of BABS 2002-2007: Lecturer, School of BABS 2000-2002: Postdoc, Emory University, Atlanta USA

研究领域

My research primarily concerns the evolution and population biology of microorganisms. I use mathematical and statistical methods to study the dynamics of bacteria and viruses. A particular focus of my research is to make inferences about the transmission patterns of infectious diseases from molecular epidemiological data. This is achieved by combining explicit mathematical models with computational statistical methods to analyse molecular data sets. I have investigated key parameters in the epidemiology of Mycobacterium tuberculosis using this approach. I have a general interest in the evolution of pathogens. Current areas include the evolution of life-history traits in viruses and the evolution of mutation rates in microbes. Another area I am developing is cultural evolution, particularly in the context of human health. I collaborate with researchers internationally and locally. Recent collaborators include Kevin Laland (St Andrews, UK), Jeremy Kendal (University of Durham, UK), Roland Regoes (ETH, Switzerland), Andrew Francis (University of Western Sydney), Scott Sisson, Miles Davenport, Ruiting Lan, Peter White and Des Cooper (UNSW). Please see the lab website for more information.

近期论文

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Chisholm RH; Trauer JM; Curnoe D; Tanaka MM, 2016, 'Controlled fire use in early humans might have triggered the evolutionary emergence of tuberculosis.', Proceedings of the National Academy of Sciences of USA, vol. 113, no. 32, pp. 9051 - 9056, http://dx.doi.org/10.1073/pnas.1603224113 Murray V; Chen JK; Tanaka MM, 2016, 'The genome-wide DNA sequence specificity of the anti-tumour drug bleomycin in human cells', Molecular Biology Reports: an international journal on molecular and cellular biology, vol. 43, no. 7, pp. 639 - 651, http://dx.doi.org/10.1007/s11033-016-3998-7 Chisholm RH; Tanaka MM, 2016, 'The emergence of latent infection in the early evolution of Mycobacterium tuberculosis', Proceedings of the Royal Society of London: Biological Sciences, vol. 283, no. 1831, http://dx.doi.org/10.1098/rspb.2016.0499 Mahendran V; Liu F; Riordan SM; Grimm MC; Tanaka MM; Zhang L, 2016, 'Examination of the effects of Campylobacter concisus zonula occludens toxin on intestinal epithelial cells and macrophages.', Gut Pathogens, vol. 8, pp. 18, http://dx.doi.org/10.1186/s13099-016-0101-9 Chan CHS; Sanders LP; Tanaka MM, 2016, 'Modelling the role of immunity in reversion of viral antigenic sites', Journal of Theoretical Biology, vol. 392, pp. 23 - 34, http://dx.doi.org/10.1016/j.jtbi.2015.12.008 Wu Y; Aandahl RZ; Tanaka MM, 2015, 'Dynamics of bacterial insertion sequences: Can transposition bursts help the elements persist? Theories and models', BMC Evolutionary Biology, vol. 15, no. 1, http://dx.doi.org/10.1186/s12862-015-0560-5 Peck KM; Chan CHS; Tanaka M, 2015, 'Connecting within-host dynamics to the rate of viral molecular evolution', Virus Evolution, vol. 1, no. 1, pp. vev013 - vev013, http://dx.doi.org/10.1093/ve/vev013 Octavia S; Wang Q; Tanaka MM; Sintchenko V; Lan R, 2015, 'Genomic variability of serial human isolates of salmonella enterica serovar typhimurium associated with prolonged carriage', Journal of Clinical Microbiology, vol. 53, no. 11, pp. 3507 - 3514, http://dx.doi.org/10.1128/JCM.01733-15 Fu S; Octavia S; Tanaka MM; Sintchenko V; Lan R, 2015, 'Defining the core genome of salmonella enterica serovar typhimurium for genomic surveillance and epidemiological typing', Journal of Clinical Microbiology, vol. 53, no. 8, pp. 2530 - 2538, http://dx.doi.org/10.1128/JCM.03407-14 Octavia S; Wang Q; Tanaka MM; Kaur S; Sintchenko V; Lan R, 2015, 'Delineating community outbreaks of Salmonella enterica serovar typhimurium by use of whole-genome sequencing: Insights into genomic variability within an outbreak', Journal of Clinical Microbiology, vol. 53, no. 4, pp. 1063 - 1071, http://dx.doi.org/10.1128/JCM.03235-14 Tanaka MM; Althouse BM; Bergstrom CT, 2014, 'Timing of antimicrobial use influences the evolution of antimicrobial resistance during disease epidemics.', Evolution, Medicine, and Public Health, vol. 2014, no. 1, pp. 150 - 161, http://dx.doi.org/10.1093/emph/eou027 Hamblin SR; White PA; Tanaka MM, 2014, 'Viral niche construction alters hosts and ecosystems at multiple scales', Trends in Ecology and Evolution, vol. 29, no. 11, pp. 594 - 599, http://dx.doi.org/10.1016/j.tree.2014.08.005 Aandahl RZ; Stadler T; Sisson SA; Tanaka MM, 2014, 'Exact vs. approximate computation: Reconciling different estimates of Mycobacterium tuberculosis epidemiological parameters', Genetics: a periodical record of investigations bearing on heredity and variation, vol. 196, no. 4, pp. 1227 - 1230, http://dx.doi.org/10.1534/genetics.113.158808 Eden JS; Hewitt J; Lim KL; Boni MF; Merif J; Greening G; Ratcliff RM; Holmes EC; Tanaka MM; Rawlinson WD; White PA, 2014, 'The emergence and evolution of the novel epidemic norovirus GII.4 variant Sydney 2012', Virology, vol. 450-451, pp. 106 - 113, http://dx.doi.org/10.1016/j.virol.2013.12.005 Egri-Nagy A; Gebhardt V; Tanaka MM; Francis AR, 2014, 'Group-theoretic models of the inversion process in bacterial genomes', Journal of Mathematical Biology, vol. 69, no. 1, pp. 243 - 265, http://dx.doi.org/10.1007/s00285-013-0702-6 Wu Y; Saddler CA; Valckenborgh F; Tanaka MM, 2014, 'Dynamics of evolutionary rescue in changing environments and the emergence of antibiotic resistance', Journal of Theoretical Biology, vol. 340, pp. 222 - 231, http://dx.doi.org/10.1016/j.jtbi.2013.09.026 Chan CHS; Hamblin S; Tanaka MM, 2013, 'The effects of linkage on comparative estimators of selection', BMC Evolutionary Biology, vol. 13, no. 1, http://dx.doi.org/10.1186/1471-2148-13-244 Saddler CA; Wu Y; Valckenborgh F; Tanaka MM, 2013, 'Epidemiological control of drug resistance and compensatory mutation under resistance testing and second-line therapy', Epidemics: the journal of infectious disease dynamics, vol. 5, no. 4, pp. 164 - 173, http://dx.doi.org/10.1016/j.epidem.2013.08.002 Hamblin S; Tanaka MM, 2013, 'Behavioural manipulation of insect hosts by Baculoviridae as a process of niche construction', BMC Evolutionary Biology, vol. 13, no. 1, http://dx.doi.org/10.1186/1471-2148-13-170 Regoes RR; Hamblin S; Tanaka MM, 2013, 'Viral mutation rates: Modelling the roles of within-host viral dynamics and the trade-off between replication fidelity and speed', Proceedings of the Royal Society of London: Biological Sciences, vol. 280, no. 1750, http://dx.doi.org/10.1098/rspb.2012.2047