个人简介
2009-current: Senior Lecturer, School of BABS
2004-9 Group Leader, Institute for Biosynthesis of Neuronal Structures, Centre for Molecular Neurobiology, Hamburg, Germany.
2002-4 Postdoctoral Fellow, Institute for Biosynthesis of Neuronal Structures, Centre for Molecular Neurobiology, Hamburg, Germany.
研究领域
The major focus of my research is on the mechanisms via which adhesion molecules of the immunoglobulin superfamily regulate the development and functioning of the brain cells – neurons.
Adhesion molecules are present at the cell surface of neurons where they function as “short-range detectors” of the environment surrounding neurons. In developing neurons, these molecules either facilitate or block neuronal growth and differentiation depending on whether the environment is permissive or inhibitory. In mature neurons, cell adhesion molecules stabilise contacts between neurons and neurons and other cells. Cell adhesion molecules also accumulate in synapses – specialised contacts between neurons that allow neurons to transmit information to each other. Importantly, most models of learning and memory invoke modification of synaptic strength as the underlying mechanism for information storage and processing in the brain.
Previous work of the group members published in The Journal of Cell Biology and Neuron showed that two adhesion molecules, NCAM and CHL1, accumulate in synapses and regulate synapse assembly and functioning. In recent research conducted in BABS, we have identified several new adhesion molecules that accumulate at synapses. Using mice as an animal model and cultured neurons as a cellular model, the group is now investigating the functions that these cell adhesion molecules play in synapses and how mutations or abnormal expression of these molecules can inflict or contribute to the brain disorders, including schizophrenia, Alzheimer’s disease, X-linked disorders and Down Syndrome.
An important direction of my work is the investigation of how the posttranslational modifications of cell adhesion molecules regulate their functions. Acylation, glycosilation and phosphorylation of the cell adhesion molecules and their involvement in neuritogenesis and synapse formation are currently being investigated.
Our hope is that this research will lead to better understanding of the aetiology of the brain disorders and will ultimately provide tools to treat these disorders.
Cell adhesion molecules in regulation of neuronal differentiation, synapse formation and function
Post-translational modifications of adhesion molecules in healthy and diseased brains
近期论文
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Bliim N; Leshchyns ka I; Sytnyk V; Janitz M, 2016, 'Transcriptional regulation of long-term potentiation', Neurogenetics, pp. 1 - 10, http://dx.doi.org/10.1007/s10048-016-0489-x
Leshchyns'Ka I; Sytnyk V, 2016, 'Synaptic Cell Adhesion Molecules in Alzheimer's Disease', NEURAL PLASTICITY, vol. 2016, http://dx.doi.org/10.1155/2016/6427537
Cheng YY; Wright CM; Kirschner MB; Williams M; Sarun KH; Sytnyk V; Leshchynska I; Edelman JJ; Vallely MP; McCaughan BC; Klebe S; van Zandwijk N; Lin RCY; Reid G, 2016, 'KCa1.1, a calcium-activated potassium channel subunit alpha 1, is targeted by miR-17-5p and modulates cell migration in malignant pleural mesothelioma', Molecular Cancer, vol. 15, no. 1, http://dx.doi.org/10.1186/s12943-016-0529-z
Leshchyns'ka I; Sytnyk V, 2016, 'Reciprocal Interactions between Cell Adhesion Molecules of the Immunoglobulin Superfamily and the Cytoskeleton in Neurons.', Frontiers in Cell and Developmental Biology, vol. 4, pp. 9, http://dx.doi.org/10.3389/fcell.2016.00009
Wobst H; Schmitz B; Schachner M; Diestel S; Leshchyns'ka I; Sytnyk V, 2015, 'Kinesin-1 promotes post-Golgi trafficking of NCAM140 and NCAM180 to the cell surface', Journal of Cell Science, vol. 128, no. 15, pp. 2816 - 2829, http://dx.doi.org/10.1242/jcs.164137
Wobst H; Schmitz B; Schachner M; Diestel S; Leshchyns'ka I; Sytnyk V, 2015, 'Kinesin-1 promotes post-Golgi trafficking of NCAM140 and NCAM180 to the cell surface', Journal of Cell Science, vol. 128, no. 15, pp. 2816 - 2829, http://dx.doi.org/10.1242/jcs.169391
Leshchyns'Ka I; Liew HT; Shepherd C; Halliday GM; Stevens CH; Ke YD; Ittner LM; Sytnyk V, 2015, 'Aβ-dependent reduction of NCAM2-mediated synaptic adhesion contributes to synapse loss in Alzheimer's disease', Nature Communications, vol. 6, http://dx.doi.org/10.1038/ncomms9836
Leshchyns'ka I; Sytnyk V, 2015, 'Intracellular transport and cell surface delivery of the neural cell adhesion molecule (NCAM).', Bioarchitecture, vol. 5, no. 3-4, pp. 54 - 60, http://dx.doi.org/10.1080/19490992.2015.1118194
Schmalbach B; Lepsveridze E; Djogo N; Papashvili G; Kuang F; Leshchyns'Ka I; Sytnyk V; Nikonenko AG; Dityatev A; Jakovcevski I; Schachner M, 2015, 'Age-dependent loss of parvalbumin-expressing hippocampal interneurons in mice deficient in CHL1, a mental retardation and schizophrenia susceptibility gene', Journal of Neurochemistry, vol. 135, no. 4, pp. 830 - 844, http://dx.doi.org/10.1111/jnc.13284
Sytnyk V; Fath T, 2015, 'Synapse Function in Dementia and Neurodegenerative Disorders', Australian Biochemist, vol. 46, no. 1, https://www.asbmb.org.au/magazine/2015_April_Issue46-1/Showcase%204%20-%20Fath.pdf
Sheng L; Leshchyns Ka I; Sytnyk V, 2015, 'Neural cell adhesion molecule 2 promotes the formation of filopodia and neurite branching by inducing submembrane increases in Ca2+ levels', The Journal of Neuroscience, vol. 35, no. 4, pp. 1739 - 1752, http://dx.doi.org/10.1523/JNEUROSCI.1714-14.2015
Robinson JW; Leshchyns'ka I; Farghaian H; Hughes WE; Sytnyk V; Neely GG; Cole AR, 2014, 'PI4KIIα phosphorylation by GSK3 directs vesicular trafficking to lysosomes', Biochemical Journal, vol. 464, pp. 145 - 156, http://dx.doi.org/10.1042/BJ20140497
Sheng L; Leshchyns'Ka I; Sytnyk V, 2013, 'Cell adhesion and intracellular calcium signaling in neurons', Cell Communication and Signaling, vol. 11, no. 1, http://dx.doi.org/10.1186/1478-811X-11-94
Shetty A; Sytnyk V; Leshchyns'ka I; Puchkov D; Haucke V; Schachner M, 2013, 'The neural cell adhesion molecule promotes maturation of the presynaptic endocytotic machinery by switching synaptic vesicle recycling from adaptor protein 3 (AP-3)- to AP-2-dependent mechanisms', The Journal of Neuroscience, vol. 33, no. 42, pp. 16828 - 16845, http://dx.doi.org/10.1523/JNEUROSCI.2192-13.2013
Li S; Leshchyns'ka I; Chernyshova Y; Schachner M; Sytnyk V, 2013, 'The neural cell adhesion molecule (NCAM) associates with and signals through p21-activated Kinase 1 (Pak1)', The Journal of Neuroscience, vol. 33, no. 2, pp. 790 - 803, http://dx.doi.org/10.1523/JNEUROSCI.1238-12.2013
Poplawski GHD; Tranziska AK; Leshchyns'ka I; Meier ID; Streichert T; Sytnyk V; Schachner M, 2012, 'L1CAM increases MAP2 expression via the MAPK pathway to promote neurite outgrowth', Molecular and Cellular Neuroscience, vol. 50, no. 2, pp. 169 - 178, http://dx.doi.org/10.1016/j.mcn.2012.03.010
Yang H; Galea A; Sytnyk V; Crossley M, 2012, 'Controlling the size of lipid droplets: Lipid and protein factors', Current Opinion in Cell Biology, vol. 24, no. 4, pp. 509 - 516, http://dx.doi.org/10.1016/j.ceb.2012.05.012
Tian N; Leshchyns'ka I; Welch JH; Diakowski W; Yang H; Schachner M; Sytnyk V, 2012, 'Lipid raft-dependent endocytosis of close homolog of adhesion molecule L1 (CHL1) promotes neuritogenesis', Journal of Biological Chemistry, vol. 287, no. 53, pp. 44447 - 44463, http://dx.doi.org/10.1074/jbc.M112.394973
Chernyshova Y; Leshchyns'ka I; Hsu SC; Schachner M; Sytnyk V, 2011, 'The neural cell adhesion molecule promotes FGFR-dependent phosphorylation and membrane targeting of the exocyst complex to induce exocytosis in growth cones.', The Journal of Neuroscience, vol. 31, no. 10, pp. 3522 - 3535, http://dx.doi.org/10.1523/JNEUROSCI.3109-10.2011
Puchkov D; Leshchyns'Ka I; Nikonenko AG; Schachner M; Sytnyk V, 2011, 'NCAM/spectrin complex disassembly results in PSD perforation and postsynaptic endocytic zone formation', Cerebral Cortex, vol. 21, no. 10, pp. 2217 - 2232, http://dx.doi.org/10.1093/cercor/bhq283
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