Murray, Vincent - University of New South Wales - School of Biotechnology and Biomolecular Science

个人简介

2002-current: Associate Professor, School of BABS 1990-2001: Lecturer, Senior Lecturer, School of BABS Cancer Institute, Melbourne 1982-1990 Princeton University 1980-1982

研究领域

I have been an active researcher in the field of molecular biology for 30 years. The overall aim of my lab is to develop more effective cancer chemotherapeutic agents based on cisplatin and bleomycin. Cisplatin and bleomycin are widely used in the clinic: cisplatin is used to treat testicular and ovarian cancer while bleomycin is utilised to treat germ cell tumours, certain types of lymphoma and squamous cell carcinomas. Both compounds are thought to act by damaging DNA inside tumour cells. Cisplatin preferentially targets G-rich DNA sequences while bleomycin targets GT and GC DNA sequences. My lab has made significant research contributions, demonstrated by publication of over 65 papers in high profile international refereed journals. I have published 3 papers in the Journal of Biological Chemistry (impact factor 5.8) and 8 in Nucleic Acids Research (impact factor 6.3). One of my Nucleic Acids Research articles has been cited over 400 times; and 13 of my papers have been cited more than 30 times. I have given seminars at 19 international and local conferences and seminar series and have helped to organise 4 conferences, and was invited to speak at the 6th Annual Congress of International Drug Discovery Science and Technology in Beijing in 2008.

近期论文

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Johnson BW; Murray V; Temple MD, 2016, 'Characterisation of the DNA sequence specificity, cellular toxicity and cross-linking properties of novel bispyridine-based dinuclear platinum complexes', BMC Cancer, vol. 16, no. 1, http://dx.doi.org/10.1186/s12885-016-2368-0 Murray V; Chen JK; Tanaka MM, 2016, 'The genome-wide DNA sequence specificity of the anti-tumour drug bleomycin in human cells', Molecular Biology Reports: an international journal on molecular and cellular biology, vol. 43, no. 7, pp. 639 - 651, http://dx.doi.org/10.1007/s11033-016-3998-7 Chen JK; Murray V, 2016, 'The determination of the DNA sequence specificity of bleomycin-induced abasic sites', Journal of Biological Inorganic Chemistry, vol. 21, no. 3, pp. 395 - 406, http://dx.doi.org/10.1007/s00775-016-1349-8 Chung LH; Murray V, 2016, 'The mitochondrial DNA sequence specificity of the anti-tumour drug bleomycin using end-labeled DNA and capillary electrophoresis and a comparison with genome-wide DNA sequencing', Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, vol. 1008, pp. 87 - 97, http://dx.doi.org/10.1016/j.jchromb.2015.11.029 Murray V; Taylor CB; Gero AM; Lutze-Mann LH, 2015, 'The influence of p53 status on the cytotoxicity of fluorinated pyrimidine L-nucleosides', Chemico-Biological Interactions, vol. 240, pp. 102 - 109, http://dx.doi.org/10.1016/j.cbi.2015.08.010 Murray V, 2015, 'The frequency of poly(G) tracts in the human genome and their use as a sensor of DNA damage', Computational Biology and Chemistry, vol. 54, pp. 13 - 17, http://dx.doi.org/10.1016/j.compbiolchem.2014.11.006 Murray V; Chen JK; Galea AM, 2014, 'Enhanced DNA repair of bleomycin-induced 3'-phosphoglycolate termini at the transcription start sites of actively transcribed genes in human cells', Mutation Research, vol. 769, pp. 93 - 99, http://dx.doi.org/10.1016/j.mrfmmm.2014.06.006 Murray V; Chen JK; Galea AM, 2014, 'The potential of acridine carboxamide Pt complexes as anti-cancer agents: A review', Anti-Cancer Agents in Medicinal Chemistry, vol. 14, no. 5, pp. 695 - 705, http://dx.doi.org/10.2174/18715206113136660361 Kava HW; Galea AM; Md Jamil F; Feng Y; Murray V, 2014, 'Characterising the atypical 5′-CG DNA sequence specificity of 9-aminoacridine carboxamide Pt complexes', Journal of Biological Inorganic Chemistry, http://dx.doi.org/10.1007/s00775-014-1144-3 Murray V; Chen JK; Galea AM, 2013, 'The anti-tumor drug bleomycin preferentially cleaves at the transcription start sites of actively transcribed genes in human cells', Cellular and Molecular Life Sciences, pp. 1 - 8, http://dx.doi.org/10.1007/s00018-013-1456-4 Nguyen TV; Chen JK; Murray V, 2013, 'Bleomycin DNA damage: Anomalous mobility of 3'-phosphoglycolate termini in an automated capillary DNA sequencer', Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, vol. 913-914, pp. 113 - 122, http://dx.doi.org/10.1016/j.jchromb.2012.11.029 Nguyen TV; Murray V, 2013, 'The electrophoretic mobility of DNA fragments differing by a single 3′-terminal nucleotide in an automated capillary DNA sequencer', Biomedical Chromatography, vol. 27, no. 3, pp. 390 - 395, http://dx.doi.org/10.1002/bmc.2804 Nguyen HTQ; Galea AM; Murray V, 2013, 'The interaction of cisplatin with a human telomeric DNA sequence containing seventeen tandem repeats', Bioorganic and Medicinal Chemistry Letters, vol. 23, no. 4, pp. 1041 - 1045, http://dx.doi.org/10.1016/j.bmcl.2012.12.021 Paul M; Murray V, 2012, 'Use of an automated capillary DNA sequencer to investigate the interaction of cisplatin with telomeric DNA sequences', Biomedical Chromatography, vol. 26, no. 3, pp. 350 - 354, http://dx.doi.org/10.1002/bmc.1664 Lung MSY; Zhang N; Murray V, 2012, 'Site-directed mutagenesis of human papillomavirus 18 promoter elements and tissue-specific expression in cervical carcinoma cells', Virus Genes, vol. 44, no. 3, pp. 395 - 402, http://dx.doi.org/10.1007/s11262-012-0723-z Murray V; Campbell HM; Gero AM, 2012, 'Plasmodium falciparum: the potential of the cancer chemotherapeutic agent cisplatin and its analogues as anti-malarials.', Experimental Parasitology, vol. 132, no. 4, pp. 440 - 443 Murray V; Kandasamy N, 2012, 'The sequence specificity of the anti-tumour drug, cisplatin, in telomeric DNA sequences compared with consecutive guanine DNA sequences', Anti-Cancer Agents in Medicinal Chemistry, vol. 12, no. 3, pp. 177 - 181 Nguyen TV; Murray V, 2012, 'Human telomeric DNA sequences are a major target for the antitumour drug bleomycin', Journal of Biological Inorganic Chemistry, vol. 17, no. 1, pp. 1 - 9, http://dx.doi.org/10.1007/s00775-011-0818-3 Murray V; Nguyen TV; Chen JK, 2012, 'The Use of Automated Sequencing Techniques to Investigate the Sequence Selectivity of DNA-Damaging Agents', Chemical Biology and Drug Design, vol. 80, no. 1, pp. 1 - 8, http://dx.doi.org/10.1111/j.1747-0285.2012.01379.x Nguyen HTQ; Murray V, 2012, 'The DNA sequence specificity of bleomycin cleavage in telomeric sequences in human cells', Journal of Biological Inorganic Chemistry, vol. 17, no. 8, pp. 1209 - 1215, http://dx.doi.org/10.1007/s00775-012-0934-8