Mitchell, Hazel - University of New South Wales - School of Biotechnology and Biomolecular Science

个人简介

2007-current: Professor, School of BABS 2002-2006: Associate Professor, School of BABS 1999-2002: Senior Lecturer, School of BABS 1996-1998: Adjunct Senior Lecturer and Senior Research Associate, School of BABS 1993-1996: NHMRC Research Associate, School of BABS

研究领域

Professor Mitchell was one of the first in the world to study the epidemiology of H. pylori infection and developed one of the first ELISA assays for the diagnosis of H. pylori infection. Using this she demonstrated that transmission was person to person and showed that infection was mostly contracted in childhood. In 1996 she was a founding organiser of the Western Pacific Helicobacter pylori study group and was convenor of the first meeting in Guangzhou, China and international scientific adviser for subsequent meetings in Malaysia, Indonesia, Australia, Japan and Thailand. Over the last 17 years she has undertaken major studies in China in the area of epidemiology, pathogenesis and gastric cancer. In 1998 she was invited by Professor I Segal to collaborate on an investigation of H. pylori infection in South Africa. This collaboration led to the award of the South African Gastroenterology Society Astra Fellowship to further develop this research collaboration on the role H. pylori virulence determinants, the immune response and host genetic factors in the causation of H. pylori related disease. In 2003, in collaboration with Professor David Forman and the Victorian Cancer Council, she initiated a major study to investigate the role of host genetic polymorphisms in gastric cancer in Australian subjects. In 2004 she was awarded a 3-year grant by the NSW Cancer Council to conduct a study with collaborators in Malaysia, Singapore, Australia and the UK into the role of bacterial, host genetic and dietary factors in gastric cancer. In addition to these collaborations, Professor Mitchell has an ongoing collaboration on I with Professor Lars Engstrand, Karolinska Institute, Sweden where she undertook a 6-month sabbatical in 2006. In addition to studies in humans, she has been involved in an increasing number of studies in animal models of disease in the areas of H. pylori pathogenesis, and investigation of the action of probiotics and IBD. In 2001 she was awarded an Eli and Edythe Broad Foundation grant to conduct preliminary studies into the role of therapeutic vaccination with Helicobacter species in a mouse model of IBD and in 2006 a second Broad Foundation grant to investigate the role of mucus associated bacteria in Crohn's disease in children. The findings of this latter grant led to the award of a 3-year NHMRC grant to continue this work.

近期论文

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Paramsothy S; Kamm M; Walsh A; van den Bogaerde J; Samuel D; Leong R; Connor S; Ng W; Paramsothy R; Kaakoush N; Mitchell H; Xuan W; Lin E; Borody T, 2016, 'Multi-donor intense faecal microbiota transplantation is an effective treatment for resistant ulcerative colitis: a randomised placebo-controlled trial', Journal of Crohn's and Colitis, vol. 10, pp. S14 - S14, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000374496600018&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a Kaakoush NO; Day AS; Leach ST; Lemberg DA; Mitchell HM, 2016, 'Reduction in Gut Microbial Diversity as a Mechanism of Action of Exclusive Enteral Nutrition', American Journal of Gastroenterology, vol. 111, no. 7, pp. 1033, http://dx.doi.org/10.1038/ajg.2016.61 Kaakoush NO; Martire SI; Raipuria M; Mitchell HM; Nielsen S; Westbrook RF; Morris MJ, 2016, 'Alternating or continuous exposure to cafeteria diet leads to similar shifts in gut microbiota compared to chow diet', Molecular Nutrition and Food Research, http://dx.doi.org/10.1002/mnfr.201500815 Mitchell H; Katelaris P, 2016, 'Epidemiology, clinical impacts and current clinical management of Helicobacter pylori infection.', Medical Journal of Australia, vol. 204, no. 10, pp. 376 - 380, http://www.ncbi.nlm.nih.gov/pubmed/27256648 Underwood AP; Kaakoush NO; Sodhi N; Merif J; Lee WS; Riordan SM; Rawlinson WD; Mitchell HM, 2016, 'Campylobacter concisus pathotypes are present at significant levels in patients with gastroenteritis', Journal of Medical Microbiology, vol. 65, no. 3, pp. 219 - 226, http://dx.doi.org/10.1099/jmm.0.000216 Timms VJ; Daskalopoulos G; Mitchell HM; Neilan BA, 2016, 'The association of mycobacterium avium subsp. paratuberculosis with inflammatory bowel disease', PLoS One, vol. 11, no. 2, http://dx.doi.org/10.1371/journal.pone.0148731 Nielsen HL; Kaakoush NO; Mitchell HM; Nielsen H, 2016, 'Immunoglobulin G response in patients with Campylobacter concisus diarrhea', Diagnostic Microbiology and Infectious Disease, vol. 84, no. 2, pp. 151 - 154, http://dx.doi.org/10.1016/j.diagmicrobio.2015.10.026 Castano Rodriguez N; Kaakoush N; Goh K; Fock K; Mitchell H, 2015, 'Correction: The NOD-Like Receptor Signalling Pathway in Helicobacter pylori Infection and Related Gastric Cancer: A Case-Control Study and Gene Expression Analyses', PLoS One, vol. 10, no. 1, pp. e0117870 - e0117870, http://dx.doi.org/10.1371/journal.pone.0117870 Deshpande NP; Wilkins MR; Mitchell HM; Kaakoush NO, 2015, 'Novel genetic markers define a subgroup of pathogenic Escherichia coli strains belonging to the B2 phylogenetic group', FEMS Microbiology Letters, vol. 362, no. 22, http://dx.doi.org/10.1093/femsle/fnv193 Nielsen HL; Kaakoush NO; Mitchell HM; Nielsen H, 2015, 'Immunoglobulin G response in patients with Campylobacter concisus diarrhea', Diagnostic Microbiology and Infectious Disease, http://dx.doi.org/10.1016/j.diagmicrobio.2015.10.026 Castaño-Rodríguez N; Kaakoush NO; Lee WS; Mitchell HM, 2015, 'Dual role of Helicobacter and Campylobacter species in IBD: A systematic review and meta-analysis', Gut, http://dx.doi.org/10.1136/gutjnl-2015-310545 Paramsothy S; Walsh AJ; Borody T; Samuel D; Van Den Bogaerde J; Leong RWL; Connor S; Ng W; Mitchell HM; Kaakoush NO; Kamm MA, 2015, 'Gastroenterologist perceptions of faecal microbiota transplantation', World Journal of Gastroenterology, vol. 21, no. 38, pp. 10907 - 10914, http://dx.doi.org/10.3748/wjg.v21.i38.10907 Timms VJ; Hassan KA; Mitchell HM; Neilan BA, 2015, 'Comparative genomics between human and animal associated subspecies of the Mycobacterium avium complex: A basis for pathogenicity', BMC Genomics, vol. 16, no. 1, http://dx.doi.org/10.1186/s12864-015-1889-2 Leach ST; Lui K; Naing Z; Dowd SE; Mitchell HM; Day AS, 2015, 'Multiple Opportunistic Pathogens, but Not Pre-existing Inflammation, May Be Associated with Necrotizing Enterocolitis', Digestive Diseases and Sciences, http://dx.doi.org/10.1007/s10620-015-3830-6 Kaakoush NO; Castaño-Rodríguez N; Mitchell HM; Man SM, 2015, 'Global epidemiology of campylobacter infection', Clinical Microbiology Reviews, vol. 28, no. 3, pp. 687 - 720, http://dx.doi.org/10.1128/CMR.00006-15 Paramsothy S; Borody TJ; Lin E; Finlayson S; Walsh AJ; Samuel D; Van Den Bogaerde J; Leong RWL; Connor S; Ng W; Mitchell HM; Kaakoush N; Kamm MA, 2015, 'Donor recruitment for fecal microbiota transplantation', Inflammatory Bowel Diseases, vol. 21, no. 7, pp. 1600 - 1606, http://dx.doi.org/10.1097/MIB.0000000000000405 Lecomte V; Kaakoush NO; Maloney CA; Raipuria M; Huinao KD; Mitchell HM; Morris MJ, 2015, 'Changes in Gut Microbiota in Rats Fed a High Fat Diet Correlate with Obesity-Associated Metabolic Parameters', PLoS One, vol. 10, no. 5, pp. e0126931 - e0126931, http://dx.doi.org/10.1371/journal.pone.0126931 Kaakoush NO; Castaño-Rodríguez N; Man SM; Mitchell HM, 2015, 'Is Campylobacter to esophageal adenocarcinoma as Helicobacter is to gastric adenocarcinoma?', Trends in Microbiology, http://dx.doi.org/10.1016/j.tim.2015.03.009 Kaakoush NO; Day AS; Leach ST; Lemberg DA; Nielsen S; Mitchell HM, 2015, 'Effect of exclusive enteral nutrition on the microbiota of children with newly diagnosed Crohn's disease', Clinical and Translational Gastroenterology, vol. 6, no. 1, http://dx.doi.org/10.1038/ctg.2014.21 Timms VJ; Mitchell HM; Neilan BA, 2015, 'Optimisation of DNA extraction and validation of PCR assays to detect Mycobacterium avium subsp. paratuberculosis', Journal of Microbiological Methods, vol. 112, pp. 99 - 103, http://dx.doi.org/10.1016/j.mimet.2015.03.016