Lan, Ruiting - University of New South Wales - School of Biotechnology and Biomolecular Science

个人简介

2010-current: Associate Professor, School of BABS 2002-2009: Senior Lecturer, School of BABS Postdoc/Research Fellow, University of Sydney

研究领域

Dr Lan came from a population genetics background and lectured in genetics before doing his PhD in molecular genetics. He combined the two fields in his research on bacterial population structures and evolution of pathogens, making unique contributions to this research field. He has made major advances in the studying of enteric pathogens and evolution of bacterial clones: Dr Lan initiated the use of genomic subtraction to study genome variation before the genome sequencing era and discovered that horizontal gene transfer is a major factor in bacterial evolution. Although that observation was met with scepticism at the time, the findings have now been confirmed by genome sequence data. Based on that study and genome data he proposed the species genome concept which has been widely cited, and the proposal has been vindicated by microarray studies and rapidly accumulating intraspecies genome data. His significant work on the origins of Shigella within E. coli resolved the long standing misnomer of Shigella as a separate genus with 4 species. The work was published in the prestigious journal, Proceedings of National Academy of Science, USA, and attracted commentaries in Science and Current Biology. Subsequently he and his colleagues elucidated the relationships of Shigella and enteroinvasive E. coli through a series of studies. His contributions have attracted invitations to write reviews. Dr Lan work on V. cholerae centred on the origins and evolution of the pandemic clones. He and his colleagues determined the population structure of V. cholerae and recently resolved the relationship of the pandemic clones and their closely related toxigenic isolates. His work on the 7th pandemic clone revealed a temporal pattern of genetic changes during the global spread of the pandemic and showed multiple independent introductions of cholera into Africa during 1970s and 1990s. Two of his major works on S. enterica were using it as a model organism to study the effect on variation of neighbouring genes by locus under selection pressure for change (the O antigen locus) and to determine the extent of horizontal gene transfer at genome level as discussed above. His studies on serovar Typhimurium, a predominant Salmonella clone, have yielded significant insights into the clone and lay the foundation for the development of a molecular phage typing scheme. His discovery of frequent recombination in subspecies I has a significant impact on our understanding of S. enterica. He also has made contributions in bioinformatics with development of software applications to studying population genetics of bacteria. He maintains two bioinformatics programs MULTICOMP and MLEECOMP, which have been distributed to the research community worldwide.

近期论文

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Safarchi A; Octavia S; Luu LDW; Tay CY; Sintchenko V; Wood N; Marshall H; McIntyre P; Lan R, 2016, 'Better colonisation of newly emerged Bordetella pertussis in the co-infection mouse model study', Vaccine, vol. 34, no. 34, pp. 3967 - 3971, http://dx.doi.org/10.1016/j.vaccine.2016.06.052 Niu L; Lu S; Hu S; Jin D; Lai X; Yang J; Chen C; Wang Y; Bai X; Lan R; Lv G; Xie Y; Ye C; Xu J, 2016, 'Streptococcus halotolerans sp. nov. isolated from the respiratory tract of Marmota himalayana in Qinghai-Tibet Plateau of China.', International Journal of Systematic and Evolutionary Microbiology, http://dx.doi.org/10.1099/ijsem.0.001337 Niu L; Lu S; Hu S; Jin D; Lai X; Yang J; Chen C; Wang Y; Wang Y; Bai X; Lan R; Lv G; Xie Y; Ye C; Xu J, 2016, 'Streptococcus marmotae sp. nov. isolated from the respiratory tract of Marmota himalayana in Qinghai-Tibet Plateau of China.', International Journal of Systematic and Evolutionary Microbiology, http://dx.doi.org/10.1099/ijsem.0.001350 Li H; Lan R; Peng N; Sun J; Zhu Y, 2016, 'High resolution melting curve analysis with MATLAB-based program', Measurement, vol. 90, pp. 178 - 186, http://dx.doi.org/10.1016/j.measurement.2016.04.057 Clarke M; McIntyre PB; Blyth CC; Wood N; Octavia S; Sintchenko V; Giles L; Quinn H; Hill V; Hanly G; Lan R; Marshall HS, 2016, 'The relationship between Bordetella pertussis genotype and clinical severity in Australian children with pertussis', Journal of Infection, vol. 72, no. 2, pp. 171 - 178, http://dx.doi.org/10.1016/j.jinf.2015.11.004 Luo Y; Octavia S; Jin D; Ye J; Miao Z; Jiang T; Xia S; Lan R, 2016, 'US Gulf-like toxigenic O1 Vibrio cholerae causing sporadic cholera outbreaks in China', Journal of Infection, vol. 72, no. 5, pp. 564 - 572, http://dx.doi.org/10.1016/j.jinf.2016.02.005 Chen D; Gong L; Walsh TR; Lan R; Wang T; Zhang J; Mai W; Ni N; Lu J; Xu J; Li J, 2016, 'Infection by and dissemination of NDM-5-producing Escherichia coli in China', Journal of Antimicrobial Chemotherapy, vol. 71, no. 2, pp. 563 - 565, http://dx.doi.org/10.1093/jac/dkv352 Qin T; Zhang W; Liu W; Zhou H; Ren H; Shao Z; Lan R; Xu J, 2016, 'Population structure and minimum core genome typing of Legionella pneumophila', Scientific Reports, vol. 6, http://dx.doi.org/10.1038/srep21356 Safarchi A; Octavia S; Wu SZ; Kaur S; Sintchenko V; Gilbert GL; Wood N; McIntyre P; Marshall H; Keil AD; Lan R, 2016, 'Genomic dissection of Australian Bordetella pertussis isolates from the 2008-2012 epidemic', Journal of Infection, http://dx.doi.org/10.1016/j.jinf.2016.01.005 Wang Y; Jiao Y; Lan R; Xu X; Liu G; Wang X; Zhang L; Pang H; Jin D; Dai H; Yuan X; Zhang W; Xu J; Ye C, 2015, 'Characterization of Listeria monocytogenes isolated from human Listeriosis cases in China', Emerging Microbes and Infections, vol. 4, no. 8, pp. e50, http://dx.doi.org/10.1038/emi.2015.50 Bai L; Lan R; Zhang X; Cui S; Xu J; Guo Y; Li F; Zhang D, 2015, 'Prevalence of salmonella isolates from chicken and pig slaughterhouses and emergence of ciprofloxacin and cefotaxime co-resistant S. enterica serovar Indiana in Henan, China', PLoS One, vol. 10, no. 12, http://dx.doi.org/10.1371/journal.pone.0144532 Octavia S; Sara J; Lan R, 2015, 'Characterization of a large novel phage-like plasmid in Salmonella enterica serovar Typhimurium', FEMS Microbiology Letters, vol. 362, no. 8, http://dx.doi.org/10.1093/femsle/fnv044 Clarke M; McIntyre PB; Blyth CC; Wood N; Octavia S; Sintchenko V; Giles L; Quinn H; Hill V; Hanly G; Lan R; Marshall HS, 2015, 'The relationship between Bordetella pertussis genotype and clinical severity in Australian children with pertussis', Journal of Infection, http://dx.doi.org/10.1016/j.jinf.2015.11.004 Safarchi A; Octavia S; Luu LDW; Tay CY; Sintchenko V; Wood N; Marshall H; McIntyre P; Lan R, 2015, 'Pertactin negative Bordetella pertussis demonstrates higher fitness under vaccine selection pressure in a mixed infection model', Vaccine, vol. 33, no. 46, pp. 6277 - 6281, http://dx.doi.org/10.1016/j.vaccine.2015.09.064 Octavia S; Wang Q; Tanaka MM; Sintchenko V; Lan R, 2015, 'Genomic variability of serial human isolates of salmonella enterica serovar typhimurium associated with prolonged carriage', Journal of Clinical Microbiology, vol. 53, no. 11, pp. 3507 - 3514, http://dx.doi.org/10.1128/JCM.01733-15 Fung CC; Octavia S; Mooney AM; Lan R, 2015, 'Virulence variations in Shigella and enteroinvasive Escherichia coli using the Caenorhabditis elegans model', FEMS Microbiology Letters, vol. 362, no. 3, http://dx.doi.org/10.1093/femsle/fnu045 Mahendran V; Octavia S; Demirbas OF; Sabrina S; Ma R; Lan R; Riordan SM; Grimm MC; Zhang L, 2015, 'Delineation of genetic relatedness and population structure of oral and enteric Campylobacter concisus strains by analysis of housekeeping genes', Microbiology, vol. 161, no. 8, pp. 1600 - 1612, http://dx.doi.org/10.1099/mic.0.000112 Liu S; Jin D; Lan R; Wang Y; Meng Q; Dai H; Lu S; Hu S; Xu J, 2015, 'Escherichia marmotae sp. nov., isolated from faeces of Marmota himalayana', International Journal of Systematic and Evolutionary Microbiology, vol. 65, no. 7, pp. 2130 - 2134, http://dx.doi.org/10.1099/ijs.0.000228 Fu S; Octavia S; Tanaka MM; Sintchenko V; Lan R, 2015, 'Defining the core genome of salmonella enterica serovar typhimurium for genomic surveillance and epidemiological typing', Journal of Clinical Microbiology, vol. 53, no. 8, pp. 2530 - 2538, http://dx.doi.org/10.1128/JCM.03407-14 Wang Y; Wang Y; Lan R; Xu H; Ma A; Li D; Dai H; Yuan X; Xu J; Ye C, 2015, 'Multiple endonuclease restriction real-time loop-mediated isothermal amplification: A novel analytically rapid, sensitive, multiplex loop-mediated isothermal amplification detection technique', The Journal of Molecular Diagnostics, vol. 17, no. 4, pp. 392 - 401, http://dx.doi.org/10.1016/j.jmoldx.2015.03.002