Janitz, Michael - University of New South Wales - School of Biotechnology and Biomolecular Science

个人简介

2008- current: Senior Lecturer, School of BABS 2000-2008 Group Leader, Max Planck Institute for Molecular Genetics, Berlin 1998-1999 Postdoctoral Fellow, German Centre for Rheumatism Research

研究领域

Michael has extensive experience in the field of transcriptomics and functional genomics. His current scientific interest focuses on investigations of gene expression and alternative splicing patterns in the human brain, in particular in the context of neurodegenerative diseases such as Alzheimer’s disease (AD) and multiple system atrophy (MSA). Previous research: During his PhD studies and subsequently as a postdoc at the German Centre for Rheumatism Research, Michael specialised in investigating the influence of the sequence polymorphism within the promoter regions of MHC class II genes in several inbred mice strains (Janitz et al. 1997; Janitz et al. 1998; Cowell et al. 1998). Joining the Max Planck Institute for Molecular Genetics (MPIMG) converged with Michael’s growing interest in studying transcription at the genome-wide level. Amongst others, he was involved in collaborative projects to characterise cDNA sequences on the level of the whole transcriptome in mice T helper cells and bovine brain (Gutjahr et al. 2005; Jann et al. 2006), respectively. While at the MPIMG, Michael and his research group focused on developing a transfected-cell array as a high-throughput genomic tool for functional analysis of genes and their products (Vanhecke and Janitz 2004). This resulted in application of the cell arrays for subcellular protein localisation studies (Hu et al. 2006; Hu et al. 2009; Hu et al. 2010), protein-protein interaction screens (Fiebitz et al. 2008), and functional promoter analysis (Cheng et al. 2010). In addition, with collaborative partners in national and European Community research programs, he applied gene expression profiling studies to identify the genes involved in T helper lymphocytes type 1 immune response (Niesner et al. 2008) and differentiation of murine palatal development (Nogai et al. 2008). His research group also developed miniaturised microarray platforms for DNA hybridization studies using PNA- (Bauer et al. 2004) and LNA-modified oligonucleotide probes (Guerasimova et al. 2006; Liu et al. 2006 and 2007), thus contributing to more efficient exploration of the genome structure and function. Present research: Since his appointment at UNSW, Michael has been focused on studying the complexity of the human transcriptome using next-generation sequencing, in particular RNA-Seq. In the last three years, Michael and colleagues published nine papers in the field of brain transcriptome and neurodegenerative diseases (please refer to the list of publications below). Examples include determination of the transcriptional isoform expression patterns specific for different regions of the Alzheimer’s disease brain (Twine et al. 2011, Mills et al. 2013). Very recently, the group also provided new insights into transcriptomes of the human hippocampus and cerebellum, revealing striking differences in splicing patterns and promoter usage (Twine et al. 2013).

近期论文

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Chen BJ; Mills JD; Takenaka K; Bliim N; Halliday GM; Janitz M, 2016, 'Characterization of circular RNAs landscape in multiple system atrophy brain.', Journal of Neurochemistry, http://dx.doi.org/10.1111/jnc.13752 Bliim N; Leshchyns ka I; Sytnyk V; Janitz M, 2016, 'Transcriptional regulation of long-term potentiation', Neurogenetics, pp. 1 - 10, http://dx.doi.org/10.1007/s10048-016-0489-x Mills JD; Ward M; Chen BJ; Iyer AM; Aronica E; Janitz M, 2016, 'LINC00507 Is Specifically Expressed in the Primate Cortex and Has Age-Dependent Expression Patterns', Journal of Molecular Neuroscience, vol. 59, no. 4, pp. 431 - 439, http://dx.doi.org/10.1007/s12031-016-0745-4 Mills JD; Ward M; Kim WS; Halliday GM; Janitz M, 2016, 'Strand-specific RNA-sequencing analysis of multiple system atrophy brain transcriptome', Neuroscience, vol. 322, pp. 234 - 250, http://dx.doi.org/10.1016/j.neuroscience.2016.02.042 Mills JD; Chen BJ; Ueberham U; Arendt T; Janitz M, 2016, 'The Antisense Transcriptome and the Human Brain', Journal of Molecular Neuroscience, vol. 58, no. 1, pp. 1 - 15, http://dx.doi.org/10.1007/s12031-015-0694-3 Ward M; McEwan C; Mills JD; Janitz M, 2015, 'Conservation and tissue-specific transcription patterns of long noncoding RNAs.', J Hum Transcr, vol. 1, no. 1, pp. 2 - 9, http://dx.doi.org/10.3109/23324015.2015.1077591 Chen BJ; Mills JD; Janitz C; Janitz M, 2015, 'RNA-sequencing to elucidate early patterns of dysregulation underlying the onset of Alzheimer's disease', , pp. 327 - 347, http://dx.doi.org/10.1007/978-1-4939-2627-5_20 Mills JD; Chen BJ; Ueberham U; Arendt T; Janitz M, 2015, 'The Antisense Transcriptome and the Human Brain', Journal of Molecular Neuroscience, pp. 1 - 15, http://dx.doi.org/10.1007/s12031-015-0694-3 Lourenco GF; Janitz M; Huang Y; Halliday GM, 2015, 'Long noncoding RNAs in TDP-43 and FUS/TLS-related frontotemporal lobar degeneration (FTLD)', Neurobiology of Disease, vol. 82, pp. 445 - 454, http://dx.doi.org/10.1016/j.nbd.2015.07.011 Mills JD; Chen J; Kim WS; Waters PD; Prabowo AS; Aronica E; Halliday GM; Janitz M, 2015, 'Long intervening non-coding RNA 00320 is human brain-specific and highly expressed in the cortical white matter', Neurogenetics, vol. 16, no. 3, pp. 201 - 213, http://dx.doi.org/10.1007/s10048-015-0445-1 Mills JD; Kavanagh T; Kim WS; Chen BJ; Waters PD; Halliday GM; Janitz M, 2015, 'High expression of long intervening non-coding RNA OLMALINC in the human cortical white matter is associated with regulation of oligodendrocyte maturation.', Molecular Brain, vol. 8, pp. 2, http://dx.doi.org/10.1186/s13041-014-0091-9 Mills JD; Sheahan PJ; Lai D; Kril JJ; Janitz M; Sutherland GT, 2014, 'The alternative splicing of the apolipoprotein E gene is unperturbed in the brains of Alzheimer’s disease patients', Molecular Biology Reports: an international journal on molecular and cellular biology, vol. 41, no. 10, pp. 6365 - 6376, http://dx.doi.org/10.1007/s11033-014-3516-8 Mills JD; Kim WS; Halliday GM; Janitz M, 2014, 'Transcriptome analysis of grey and white matter cortical tissue in multiple system atrophy', Neurogenetics, http://dx.doi.org/10.1007/s10048-014-0430-0 Chen J; Mills JD; Halliday GM; Janitz M, 2014, 'The role of transcriptional control in multiple system atrophy', Neurobiology of Aging, http://dx.doi.org/10.1016/j.neurobiolaging.2014.08.015 Suchowerska A; Chen B; Mueller J; Ittner A; Hardeman E; Ittner L; Janitz M; Gunning P; Fath T, 2013, 'Increased levels of actin filaments containing the tropomyosin Tm5NM1 regulate excitotoxicity in the mouse', Molecular Biology of the Cell, vol. 24, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209348702020&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a Mills JD; Kavanagh T; Kim WS; Chen BJ; Kawahara Y; Halliday GM; Janitz M, 2013, 'Unique Transcriptome Patterns of the White and Grey Matter Corroborate Structural and Functional Heterogeneity in the Human Frontal Lobe', PLoS One, vol. 8, no. 10, http://dx.doi.org/10.1371/journal.pone.0078480 Twine NA; Janitz C; Wilkins MR; Janitz M, 2013, 'Sequencing of hippocampal and cerebellar transcriptomes provides new insights into the complexity of gene regulation in the human brain', Neuroscience Letters, vol. 541, pp. 263 - 268, http://dx.doi.org/10.1016/j.neulet.2013.02.034 Mills JD; Nalpathamkalam T; Jacobs HIL; Janitz C; Merico D; Hu P; Janitz M, 2013, 'RNA-Seq analysis of the parietal cortex in Alzheimer's disease reveals alternatively spliced isoforms related to lipid metabolism', Neuroscience Letters, vol. 536, no. 1, pp. 90 - 95, http://dx.doi.org/10.1016/j.neulet.2012.12.042 Mills JD; Kawahara Y; Janitz M, 2013, 'Strand-specific RNA-Seq provides greater resolution of transcriptome profiling', Current Genomics, vol. 14, no. 3, pp. 173 - 181, http://dx.doi.org/10.2174/1389202911314030003 Janitz K; Janitz M, 2012, 'Moving Towards Third-Generation Sequencing Technologies', , pp. 323 - 336, http://dx.doi.org/10.1002/9783527644582.ch20