Hoehn, Kyle - University of New South Wales - School of Biotechnology and Biomolecular Science

研究领域

Obesity contributes to the pathogenesis of numerous metabolic diseases, including cancer and diabetes. My laboratory is focused on identifying the key metabolic alterations that contribute to the development of obesity-related disorders and testing whether targeting cellular metabolism represents a viable therapeutic approach to treat these diseases.

近期论文

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Narayanan S; Nieh AH; Kenwood BM; Davis CA; Tosello-Trampont AC; Elich TD; Breazeale SD; Ward E; Anderson RJ; Caldwell SH; Hoehn KL; Hahn YS, 2016, 'Distinct Roles for Intracellular and Extracellular Lipids in Hepatitis C Virus Infection.', PLoS One, vol. 11, no. 6, pp. e0156996, http://dx.doi.org/10.1371/journal.pone.0156996 Byrne FL; Hoehn KL, 2016, 'Subclassification of fatty liver by its pathogenesis: CIEFing is believing', Journal of Pathology, vol. 239, no. 1, pp. 3 - 5, http://dx.doi.org/10.1002/path.4702 Biwer LA; Taddeo EP; Kenwood BM; Hoehn KL; Straub AC; Isakson BE, 2016, 'Two functionally distinct pools of eNOS in endothelium are facilitated by myoendothelial junction lipid composition.', Biochimica et Biophysica Acta: international journal of biochemistry and biophysics, vol. 1861, no. 7, pp. 671 - 679, http://dx.doi.org/10.1016/j.bbalip.2016.04.014 Healy ME; Lahiri S; Hargett SR; Chow JDY; Byrne FL; Breen DS; Kenwood BM; Taddeo EP; Lackner C; Caldwell SH; Hoehn KL, 2016, 'Dietary sugar intake increases liver tumor incidence in female mice', Scientific Reports, vol. 6, http://dx.doi.org/10.1038/srep22292 Brandon AE; Stuart E; Leslie SJ; Hoehn KL; James DE; Kraegen EW; Turner N; Cooney GJ, 2016, 'Minimal impact of age and housing temperature on the metabolic phenotype of Acc2-/- mice.', Journal of Endocrinology, vol. 228, no. 3, pp. 127 - 134, http://dx.doi.org/10.1530/JOE-15-0444 Lee JE; Walsh MC; Hoehn KL; James DE; Wherry EJ; Choi Y, 2015, 'Acetyl CoA Carboxylase 2 Is Dispensable for CD8+ T Cell Responses.', PLoS One, vol. 10, no. 9, pp. e0137776, http://dx.doi.org/10.1371/journal.pone.0137776 Du X; Zhang Y; Jo SR; Liu X; Qi Y; Osborne B; Byrne FL; Smith GC; Turner N; Hoehn KL; Brown AJ; Yang H, 2015, 'Akt activation increases cellular cholesterol by promoting the proteasomal degradation of Niemann-Pick C1', Biochemical Journal, vol. 471, no. 2, pp. 243 - 253, http://dx.doi.org/10.1042/BJ20150602 Hargett SR; Walker NN; Hussain SS; Hoehn KL; Keller SR, 2015, 'Deletion of the rab GAP Tbc1d1 modifies glucose, lipid, and energy homeostasis in mice', American Journal of Physiology: Endocrinology and Metabolism, vol. 309, no. 3, pp. E233 - E245, http://dx.doi.org/10.1152/ajpendo.00007.2015 Modesitt SC; Hallowell PT; Slack-Davis JK; Michalek RD; Atkins KA; Kelley SL; Arapovic S; Shupnik MA; Hoehn K, 2015, 'Women at extreme risk for obesity-related carcinogenesis: Baseline endometrial pathology and impact of bariatric surgery on weight, metabolic profiles and quality of life', Gynecologic Oncology, vol. 138, no. 2, pp. 238 - 245, http://dx.doi.org/10.1016/j.ygyno.2015.05.015 Kenwood BM; Calderone JA; Taddeo EP; Hoehn KL; Santos WL, 2015, 'Structure-activity relationships of furazano[3,4-b]pyrazines as mitochondrial uncouplers', Bioorganic and Medicinal Chemistry Letters, http://dx.doi.org/10.1016/j.bmcl.2015.06.040 Cronk SM; Kelly-Goss MR; Ray HC; Mendel TA; Hoehn KL; Bruce AC; Dey BK; Guendel AM; Tavakol DN; Herman IM; Peirce SM; Yates PA, 2015, 'Adipose-derived stem cells from diabetic mice show impaired vascular stabilization in a murine model of diabetic retinopathy', Stem cells translational medicine, vol. 4, no. 5, pp. 459 - 467, http://dx.doi.org/10.5966/sctm.2014-0108 Bajwa A; Rosin DL; Chroscicki P; Lee S; Dondeti K; Ye H; Kinsey GR; Stevens BK; Jobin K; Kenwood BM; Hoehn KL; Lynch KR; Okusa MD, 2015, 'Sphingosine 1-phosphate receptor-1 enhances mitochondrial function and reduces cisplatin-induced tubule injury', Journal of the American Society of Nephrology, vol. 26, no. 4, pp. 908 - 925, http://dx.doi.org/10.1681/ASN.2013121351 Kashatus JA; Nascimento A; Myers LJ; Sher A; Byrne FL; Hoehn KL; Counter CM; Kashatus DF, 2015, 'Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth', Molecular Cell, vol. 57, no. 3, pp. 537 - 552, http://dx.doi.org/10.1016/j.molcel.2015.01.002 Serasinghe MN; Wieder SY; Renault TT; Elkholi R; Asciolla JJ; Yao JL; Jabado O; Hoehn K; Kageyama Y; Sesaki H; Chipuk JE, 2015, 'Mitochondrial division is requisite to RAS-induced transformation and targeted by oncogenic MAPK pathway inhibitors', Molecular Cell, vol. 57, no. 3, pp. 521 - 537, http://dx.doi.org/10.1016/j.molcel.2015.01.003 Healy ME; Chow JDY; Byrne FL; Breen DS; Leitinger N; Li C; Lackner C; Caldwell SH; Hoehn KL, 2015, 'Dietary effects on liver tumor burden in mice treated with the hepatocellular carcinogen diethylnitrosamine', Journal of Hepatology, vol. 62, no. 3, pp. 599 - 606, http://dx.doi.org/10.1016/j.jhep.2014.10.024 Laker RC; Xu P; Ryall KA; Sujkowski A; Kenwood BM; Chain KH; Zhang M; Royal MA; Hoehn KL; Driscoll M; Adler PN; Wessells RJ; Saucerman JJ; Yan Z, 2014, 'A novel mitotimer reporter gene for mitochondrial content, structure, stress, and damage in vivo', Journal of Biological Chemistry, vol. 289, no. 17, pp. 12005 - 12015, http://dx.doi.org/10.1074/jbc.M113.530527 Byrne FL; Poon IKH; Modesitt SC; Tomsig JL; Chow JDY; Healy ME; Baker WD; Atkins KA; Lancaster JM; Marchion DC; Moley KH; Ravichandran KS; Slack-Davis JK; Hoehn KL, 2014, 'Metabolic vulnerabilities in endometrial cancer', Cancer Research, vol. 74, no. 20, pp. 5832 - 5845, http://dx.doi.org/10.1158/0008-5472.CAN-14-0254 Kenwood BM; Weaver JL; Bajwa A; Poon IK; Byrne FL; Murrow BA; Calderone JA; Huang L; Divakaruni AS; Tomsig JL; Okabe K; Lo RH; Cameron Coleman G; Columbus L; Yan Z; Saucerman JJ; Smith JS; Holmes JW; Lynch KR; Ravichandran KS; Uchiyama S; Santos WL; Rogers GW; Okusa MD; Bayliss DA; Hoehn KL, 2014, 'Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane', Molecular Metabolism, vol. 3, no. 2, pp. 114 - 123, http://dx.doi.org/10.1016/j.molmet.2013.11.005 Laker RC; Lillard TS; Okutsu M; Zhang M; Hoehn KL; Connelly JJ; Yan Z, 2014, 'Exercise prevents maternal high-fat diet-induced hypermethylation of the Pgc-1α gene and age-dependent metabolic dysfunction in the offspring', Diabetes, vol. 63, no. 5, pp. 1605 - 1611, http://dx.doi.org/10.2337/db13-1614 Lee JE; Walsh MC; Hoehn KL; James DE; Wherry EJ; Choi Y, 2014, 'Regulator of fatty acid metabolism, acetyl coenzyme a carboxylase 1, controls T cell immunity', Journal of Immunology, vol. 192, no. 7, pp. 3190 - 3199, http://dx.doi.org/10.4049/jimmunol.1302985