Collins, Andrew - University of New South Wales - School of Biotechnology and Biomolecular Science

个人简介

2002-present: Associate Professor, School of BABS 2008-2010: Deputy Head of School, School of BABS 2000-2002: Head of School, UNSW School of Microbiology & Immunology 1991-2002: Lecturer; Senior Lecturer, UNSW School of Microbiology & Immunology 1990: Research Scientist, Division of Pathology, Royal Children's Hospital, Melbourne 1985-1986: Research Assistant, WHO Collaborating Centre for the Epidemiology of Diabetes Mellitus, Southern Memorial Hospital, Melbourne 1981-1984: Assistant to Director, Papua New Guinea Institute of Medical Research, Goroka

研究领域

My group focuses upon the analysis of immunoglobulin gene sequences. We have a longstanding interest in the analysis of IgE-associated VDJ genes, and more recently have focused upon IgG-associated VDJ genes. There are four human IgG subclasses, and curiously, the two most prominent IgG subclasses (IgG1 and IgG2) have essentially opposing functions. IgG1 fixes complement and binds to the low affinity Fc gamma RII and Fc gamma RIII, while IgG2 neither fixes complement nor binds effectively to these Fc gamma Rs. Yet, despite these opposing functions, both subclasses are often produced in response to antigen exposure.

近期论文

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Collins AM, 2016, 'IgG subclass co-expression brings harmony to the quartet model of murine IgG function.', Immunology and Cell Biology, http://dx.doi.org/10.1038/icb.2016.65 Kidd MJ; Jackson KJL; Boyd SD; Collins AM, 2016, 'DJ pairing during VDJ recombination shows positional biases that vary among individuals with differing IGHD locus immunogenotypes', Journal of Immunology, vol. 196, no. 3, pp. 1158 - 1164, http://dx.doi.org/10.4049/jimmunol.1501401 Collins AM; Wang Y; Roskin KM; Marquis CP; Jackson KJL, 2015, 'The mouse antibody heavy chain repertoire is germline-focused and highly variable between inbred strains', Philosophical Transactions of the Royal Society of London: Biological Sciences, vol. 370, no. 1676, http://dx.doi.org/10.1098/rstb.2014.0236 Wong KJ; Timbrell V; Xi Y; Upham JW; Collins AM; Davies JM, 2015, 'IgE+ B cells are scarce, but allergen-specific B cells with a memory phenotype circulate in patients with allergic rhinitis', Allergy, vol. 70, no. 4, pp. 420 - 428, http://dx.doi.org/10.1111/all.12563 Jackson KJL; Wang Y; Collins AM, 2014, 'Human immunoglobulin classes and subclasses show variability in VDJ gene mutation levels', Immunology and Cell Biology, vol. 92, no. 8, pp. 729 - 733, http://dx.doi.org/10.1038/icb.2014.44 Wang Y; Jackson KJL; Davies J; Chen Z; Gaeta BA; Rimmer J; Sewell WA; Collins AM, 2014, 'IgE-associated IGHV genes from venom and peanut allergic individuals lack mutational evidence of antigen selection', PLoS One, vol. 9, no. 2, http://dx.doi.org/10.1371/journal.pone.0089730 Tse BWC; Collins A; Oehler MK; Zippelius A; Heinzelmann-Schwarz VA, 2014, 'Antibody-based immunotherapy for ovarian cancer: Where are we at?', Annals of Oncology, vol. 25, no. 2, pp. 322 - 331, http://dx.doi.org/10.1093/annonc/mdt405 Jackson KJL; Kidd MJ; Wang Y; Collins AM, 2013, 'The shape of the lymphocyte receptor repertoire: Lessons from the B cell receptor', Frontiers in Immunology, vol. 4, no. SEP, http://dx.doi.org/10.3389/fimmu.2013.00263 Collins AM; Jackson KJL, 2013, 'A temporal model of human IgE and IgG antibody function', Frontiers in Immunology, vol. 4, no. AUG, http://dx.doi.org/10.3389/fimmu.2013.00235 Collins AM; Davies JM, 2013, 'Enhanced cell-binding by allergen multimers: How complex is it', Immunology and Cell Biology, vol. 91, no. 2, pp. 115 - 117, http://dx.doi.org/10.1038/icb.2013.5 Jackson KJL; Wang Y; Gaeta BA; Pomat W; Siba P; Rimmer J; Sewell WA; Collins AM, 2012, 'Divergent human populations show extensive shared IGK rearrangements in peripheral blood B cells', Immunogenetics, vol. 64, no. 1, pp. 3 - 14, http://dx.doi.org/10.1007/s00251-011-0559-z Kidd MJ; Chen Z; Wang Y; Jackson KJ; Zhang L; Boyd SD; Fire AZ; Tanaka MM; Gaëta BA; Collins AM, 2012, 'The inference of phased haplotypes for the immunoglobulin H chain V region gene loci by analysis of VDJ gene rearrangements', Journal of Immunology, vol. 188, no. 3, pp. 1333 - 1340, http://dx.doi.org/10.4049/jimmunol.1102097 Collins A, 2011, 'Old Guinean gifts', New Scientist, vol. 211, no. 2828, pp. 32 - 33, http://dx.doi.org/10.1016/S0262-4079(11)62155-6 Wang Y; Jackson KJL; Chen Z; Gaëta BA; Siba PM; Pomat W; Walpole E; Rimmer J; Sewell WA; Collins AM, 2011, 'IgE sequences in individuals living in an area of endemic parasitism show little mutational evidence of antigen selection', Scandinavian Journal of Immunology, vol. 73, no. 5, pp. 496 - 504, http://dx.doi.org/10.1111/j.1365-3083.2011.02525.x Wang Y; Jackson KJ; Gäeta B; Pomat W; Siba P; Sewell WA; Collins AM, 2011, 'Genomic screening by 454 pyrosequencing identifies a new human IGHV gene and sixteen other new IGHV allelic variants', Immunogenetics, vol. 63, no. 5, pp. 259 - 265, http://dx.doi.org/10.1007/s00251-010-0510-8 Pratt E; Collins AM; Sewell WA; Harvey RJ, 2010, 'Antigen selection in IgE antibodies from individuals with chronic rhinosinusitis with nasal polyps', American Journal of Rhinology and Allergy, vol. 24, no. 6, pp. 416 - 421, http://dx.doi.org/10.2500/ajra.2010.24.3538 Boyd SD; Gaëta BA; Jackson KJ; Fire AZ; Marshall EL; Merker JD; Maniar JM; Zhang LN; Sahaf B; Jones CD; Simen BB; Hanczaruk B; Nguyen KD; Nadeau KC; Egholm M; Miklos DB; Zehnder JL; Collins AM, 2010, 'Individual variation in the germline Ig gene repertoire inferred from variable region gene rearrangements', Journal of Immunology, vol. 184, no. 12, pp. 6986 - 6992, http://dx.doi.org/10.4049/jimmunol.1000445 Jackson KJL; Boyd S; Gaëta BA; Collins AM, 2010, 'Benchmarking the performance of human antibody gene alignment utilities using a 454 sequence dataset', Bioinformatics, vol. 26, no. 24, pp. 3129 - 3130, http://dx.doi.org/10.1093/bioinformatics/btq604 Wang Y; Jackson KJL; Sewell WA; Collins AM, 2008, 'Many human immunoglobulin heavy-chain IGHV gene polymorphisms have been reported in error', Immunology and Cell Biology, vol. 86, no. 2, pp. 111 - 115, http://dx.doi.org/10.1038/sj.icb.7100144 Collins AM; Wang Y; Singh V; Yu P; Jackson KJ; Sewell WA, 2008, 'The reported germline repertoire of human immunoglobulin kappa chain genes is relatively complete and accurate', Immunogenetics, vol. 60, no. 11, pp. 669 - 676, http://dx.doi.org/10.1007/s00251-008-0325-z