Bridge, Wallace - University of New South Wales - School of Biotechnology and Biomolecular Science

个人简介

2008-current: Senior Lecturer, School of BABS 2001-2008 Entrepreneurs in Science Unit (Faculty of Science), Director 1998-2001 CRC FII, Program Leader and Commercial Project Manager 1994-1997 Group Leader (BPC), Program Leader CRC for Food Industry Innovation 1992-1994 Roferm SpA., Italy, Senior Research Scientist 1989-1992 UNSW Dept. Biotechnology, Research Scientist 1988-1989 Aplin & Barrett, UK, Research Scientist1986-1997 Burns Philp & Co. Ltd (BPC).1984-1986 CSR Ltd., Research Scientist 1986-1988 CSIRO Division Food Research, Research Scientist

研究领域

My research group has developed a patent-protected biocatalytic-based process for the manufacture of gamma linked peptides, which has been licensed to Biospecialties International Pty Ltd (BSI) by UNSW’s commercialisation company, New South Innovations Ltd (NSi) for the manufacture of the natural thiol antioxidant, gamma-glutamyl cysteine (GGC). The GGC dipeptide is the immediate precursor to the tripeptide glutathione, which is commonly referred to as the master antioxidant as it is produced and used by almost all aerobic cells from bacteria through to human. Many diseases and disorders and even ageing itself are associated with lowered cellular glutathione levels, which may be insufficient to protect against oxidative stress that results from a related increase in reactive oxygen species (ROS). As GGC can elevate cellular glutathione content, it may have a broad range of potential applications as an active ingredient in dietary supplement, cosmetics and functional foods, and possibly as a therapeutic for a large range of clinical disorders and diseases.

近期论文

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Braidy N; Zarka M; Welch J; Bridge W, 2015, 'Therapeutic approaches to modulating glutathione levels as a pharmacological strategy in Alzheimer’s disease', Current Alzheimer Research, vol. 12, no. 4, pp. 298 - 313 Braidy N; Essa MM; Bridge WB; Subash SS; Manivasagam TM; Vijayan RKV; Al-Adawi SA; Guillemin GG, 2014, 'REVIEW OF NATURAL PRODUCTS ON PARKINSON’S DISEASE PATHOLOGY', Journal of Aging Research & Clinical Practice, vol. 3, no. 3, pp. 127 - 136 Chandler SD; Zarka MH; Vinaya Babu SN; Suhas YS; Raghunatha Reddy KR; Bridge WJ, 2012, 'Safety assessment of gamma-glutamylcysteine sodium salt', Regulatory Toxicology and Pharmacology, vol. 64, no. 1, pp. 17 - 25, http://dx.doi.org/10.1016/j.yrtph.2012.05.008 Hine D; Barnard R; Rifkin W; Bridge W; Franco C; Schmidt L; MacKinnon P, 2008, 'University biotechnology education in Australia in an international context', Journal of Biotechnology, vol. 136, pp. S770 - S770, http://dx.doi.org/10.1016/j.jbiotec.2008.07.1665 Boonmee M; Leksawasdi N; Bridge W; Rogers PL, 2007, 'Electrodialysis for lactate removal in the production of the dairy starter culture Lactococcus lactis NZ133', International Journal of Food Science and Technology, vol. 42, no. 5, pp. 567 - 572, http://dx.doi.org/10.1111/j.1365-2621.2006.01276.x Boonmee M; Leksawasdi N; Bridge W; Rogers PL, 2003, 'Batch and continuous culture of Lactococcus lactis NZ133: Experimental data and model development', Biochemical Engineering Journal, vol. 14, no. 2, pp. 127 - 135, http://dx.doi.org/10.1016/S1369-703X(02)00171-7