Ballard, Bill - University of New South Wales - School of Biotechnology and Biomolecular Science

个人简介

2013-current: Professor, School of BABS 2008-2013: Professor & Head of School, BABS 2006-2008: Professor, School of BABS 2001-2006: Professor, University of Iowa 1998-2001: Pritzker Curator, The Field Museum, Chicago 1995-1998: Assistant Curator, The Field Museum, Chicago

研究领域

Ballard's research is focused but has broad application in the fields of population genetics and ageing. He has published significant invited reviews e.g. Ballard and Rand (2005), Ballard and Whitlock (2004). Notable among these is Ballard and Whitlock, which has been cited over 280 times and is now recognised as an ISI Citation Classic. In the field of population genetics his work has informed the debate questioning whether biological species can be defined on the basis of mitochondrial DNA (Ballard and Rand (2005), Ballard (2004) and Ballard and Whitlock (2004)). He was the first to show that mtDNA can influence multiple life-history traits, including lifespan, development time, physical activity and frequency of genotypes in population cages (James and Ballard (2003), Ballard et al. (2007)). Examination of the evolutionary forces that influence mitochondrial DNA continues to be relevant with the increasing use of 'DNA Barcoding' to describe species diversity. In the field of ageing, Ballard has questioned how and why specific mutations influence bioenergetics. He has recently published the quaternary structure model of Drosophila Complex IV of the electron transport chain. This enables him to make functional predictions of specific mutations. Over the past five years, he has developed a battery of assays necessary for the detection of bioenergetic differences within a single species of Drosophila (Ballard et al. 2007; Melvin and Ballard 2006; Ballard et al. 2007). These assays will be used in future studies linking bioenergetics with diet. In February 2008 he collaborated on a PNAS paper that was the first use of the Geometric Framework to explore diet restriction and longevity in Drosophila (Lee et al. 2008).

近期论文

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O Ballard JW; Youngson NA, 2015, 'Review: Can diet influence the selective advantage of mitochondrial DNA haplotypes?', Bioscience Reports: molecular and cellular biology of the cell surface, vol. 35, no. 6, http://dx.doi.org/10.1042/BSR20150232 Le Couteur DG; Tay SS; Solon-Biet S; Bertolino P; McMahon AC; Cogger VC; Colakoglu F; Warren A; Holmes AJ; Pichaud N; Horan M; Correa C; Melvin RG; Turner N; O Ballard JW; Ruohonen K; Raubenheimer D; Simpson SJ, 2015, 'The influence of macronutrients on splanchnic and hepatic lymphocytes in aging mice', Journal of Gerontology Series A: Biological Sciences and Medical Sciences, vol. 70, no. 12, pp. 1499 - 1507, http://dx.doi.org/10.1093/gerona/glu196 Solon-Biet SM; Walters KA; Simanainen UK; McMahon AC; Ruohonen K; Ballard JWO; Raubenheimer D; Handelsman DJ; Couteur DGL; Simpson SJ, 2015, 'Macronutrient balance, reproductive function, and lifespan in aging mice', Proceedings of the National Academy of Sciences of USA, vol. 112, no. 11, pp. 3481 - 3486, http://dx.doi.org/10.1073/pnas.1422041112 Chung PP; Chu I; Ballard JWO, 2014, 'Assessment of temporal genetic variability of two epibenthic amphipod species in an eastern Australian estuarine environment and their suitability as biological monitors', Australian Journal of Zoology, vol. 62, no. 3, pp. 206 - 215, http://dx.doi.org/10.1071/ZO13104 Cogger VC; Svistounov D; Warren A; Zykova S; Melvin RG; Solon-Biet SM; O'reilly JN; Mcmahon AC; Ballard JWO; De Cabo R; Le Couteur DG; Lebel M, 2014, 'Liver aging and pseudocapillarization in a werner syndrome mouse model', Journal of Gerontology Series A: Biological Sciences and Medical Sciences, vol. 69, no. 9, pp. 1076 - 1086, http://dx.doi.org/10.1093/gerona/glt169 Song WH; Ballard JWO; Yi YJ; Sutovsky P, 2014, 'Regulation of mitochondrial genome inheritance by autophagy and ubiquitin-proteasome system: Implications for health, fitness, and fertility', BioMed Research International, vol. 2014, http://dx.doi.org/10.1155/2014/981867 Solon-Biet SM; McMahon AC; Ballard JWO; Ruohonen K; Wu LE; Cogger VC; Warren A; Huang X; Pichaud N; Melvin RG; Gokarn R; Khalil M; Turner N; Cooney GJ; Sinclair DA; Raubenheimer D; Le Couteur DG; Simpson SJ, 2014, 'The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice', Cell Metabolism, vol. 19, no. 3, pp. 418 - 430, http://dx.doi.org/10.1016/j.cmet.2014.02.009 Correa CC; Ballard JWO, 2014, 'What can symbiont titres tell us about co-evolution of Wolbachia and their host?', Journal of Invertebrate Pathology, vol. 118, pp. 20 - 27, http://dx.doi.org/10.1016/j.jip.2014.02.009 Ballard JWO; Pichaud N, 2014, 'Mitochondrial DNA: More than an evolutionary bystander', Functional Ecology, vol. 28, no. 1, pp. 218 - 231, http://dx.doi.org/10.1111/1365-2435.12177 Braidy N; Gai WP; Xu YH; Sachdev P; Guillemin GJ; Jiang XM; Ballard JWO; Horan MP; Fang ZM; Chong BH; Chan DKY, 2014, 'Alpha-synuclein transmission and mitochondrial toxicity in primary human foetal enteric neurons in vitro', Neurotoxicity Research, vol. 25, no. 2, pp. 170 - 182, http://dx.doi.org/10.1007/s12640-013-9420-5 Pichaud N; Messmer M; Correa CC; Ballard JWO, 2013, 'Diet influences the intake target and mitochondrial functions of Drosophila melanogaster males', Mitochondrion, vol. 13, no. 6, pp. 817 - 822, http://dx.doi.org/10.1016/j.mito.2013.05.008 Chung PP; Ballard JWO; Hyne RV, 2013, 'Differential survival and reproductive performance across three mitochondrial lineages in Melita plumulosa following naphthalene exposure', Chemosphere, vol. 93, no. 6, pp. 1064 - 1069, http://dx.doi.org/10.1016/j.chemosphere.2013.05.079 Braidy N; Gai WP; Xu YH; Sachdev P; Guillemin GJ; Jiang XM; Ballard JWO; Horan MP; Fang ZM; Chong BH; Chan DKY, 2013, 'Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts', Translational Neurodegeneration, vol. 2, no. 1, http://dx.doi.org/10.1186/2047-9158-2-20 Wolff JN; Sutovsky P; Ballard JWO, 2013, 'Mitochondrial DNA content of mature spermatozoa and oocytes in the genetic model Drosophila', Cell and Tissue Research, vol. 353, no. 1, pp. 195 - 200, http://dx.doi.org/10.1007/s00441-013-1628-4 Aw WC; Ballard JWO, 2013, 'The effects of temperature and diet on age grading and population age structure determination in Drosophila', Journal of Insect Physiology, vol. 59, no. 10, pp. 994 - 1000, http://dx.doi.org/10.1016/j.jinsphys.2013.07.005 Wolff JN; Nafisinia M; Sutovsky P; Ballard JWO, 2013, 'Paternal transmission of mitochondrial DNA as an integral part of mitochondrial inheritance in metapopulations of Drosophila simulans', Heredity, vol. 110, no. 1, pp. 57 - 62, http://dx.doi.org/10.1038/hdy.2012.60 Pichaud N; Ballard JWO; Tanguay RM; Blier PU, 2013, 'Mitochondrial haplotype divergences affect specific temperature sensitivity of mitochondrial respiration', Journal of Bioenergetics and Biomembranes, vol. 45, no. 1-2, pp. 25 - 35, http://dx.doi.org/10.1007/s10863-012-9473-9 Horan MP; Rumbley JN; Melvin RG; Le Couteur DG; Ballard JWO, 2013, 'Quaternary protein modeling to predict the function of DNA variation found in human mitochondrial cytochrome c oxidase', Journal of Human Genetics, vol. 58, no. 3, pp. 127 - 134, http://dx.doi.org/10.1038/jhg.2012.144 Pichaud N; Garratt M; Ballard JWO; Brooks RC, 2013, 'Physiological adaptations to reproduction. II. Mitochondrial adjustments in livers of lactating mice', The Journal of Experimental Biology, vol. 216, no. 15, pp. 2889 - 2895, http://dx.doi.org/10.1242/jeb.082685 Chung PP; Hyne RV; Mann RM; Ballard JWO, 2013, 'The impact of historic isolation on the population biogeography of Melita plumulosa (Crustacea: Melitidae) in eastern Australia', Estuarine, Coastal and Shelf Science, vol. 129, pp. 198 - 205, http://dx.doi.org/10.1016/j.ecss.2013.05.025