Morris, Jonathan - University of New South Wales

个人简介

Graduate of the University of Western Australia (B.Sc.(Hons 1), 1990) and the Australian National University (Ph.D., 1994). Postdoctoral Research Fellow, The University of Texas at Austin (1994-1996). Lecturer/Senior Lecturer, University of Canterbury (1997-2004). Lecturer/Senior Lecturer, University of Adelaide (2004-2009). Appointed Associate Professor at UNSW (2009). Appointed Deputy Dean of Graduate Research at UNSW (2015).

研究领域

Research in the Morris group is mainly focused on the synthesis of naturally occurring compounds that have profound biological activities, with the aim of using these molecules to help answer questions of importance in biology and medicine. To be able to do this, we must develop new strategies and generate new methodologies so that we can prepare molecules in an efficient and reliable manner. Working on such projects provides excellent training in synthetic and medicinal chemistry. Our work on variolin B provides an illustration of our approach. Variolin B is a marine alkaloid isolated from an extremely rare Antarctic sponge, which has emerged as an important lead for drug discovery and development. We devised the first synthetic route to variolin B, restoring access to this valuable material. In collaboration with Prof Laurent Meijer (CNRS, France) we have determined that the variolins are potent protein kinase inhibitors. X-ray crystallography of variolin B bound to the CDK2-cyclin A protein complex has provided us with a clear idea of how the compound binds in the active site. With this information, we are currently focused on developing the biomedical potential of the variolins and related alkaloids.

近期论文

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"The Variolins and Related Alkaloids", Walker, S. R.; Carter, E. J.; Huff, B. C.; Morris, J. C., Chem. Rev. 2009, 3080. "Preparation of a Super Bulky Silver N-Heterocyclic Carbene Complex", Alexander, S. G.; Cole, M. L.; Morris, J. C., New J. Chem., 2009, 33, 720. "Synthesis, protein kinase inhibitory activity and cytotoxicity of 3-(pyrimidin-4-yl)-7-azaindoles (meriolins). CDK2/cyclin A/meriolin and CDK2/cyclin A/variolin B crystal structures", Echalier, A.; Bettayeb, K.; Ferandin, Y.; Lozach, O.; Clement, M.; Valette, A.; Liger, F.; Marquet, B.; Morris, J.C.; Endicott, J.; Joseph, B.; Meijer, L., J. Med. Chem. 2008, 51, 735. "Meriolins, a new class of cell death-inducing, cyclin-dependent kinase inhibitors with enhanced selectivity for CDK9", Bettayeb, K.; Tirado, O. M.; Marionneau-Lambot, S.; Ferandin, Y.; Lozach, O.; Morris, J.C.; Mateo-Lozano, S.; Drückes, P.; Schächtele, C.; Kubbutat, M.; Liger, F.; Marquet, B.; Joseph, B.; Echalier, A.; Endicott, J.; Notario, V.; Meijer, L., Cancer Research, 2007, 67, 8325-8334. "Total Synthesis of the 7,3'-Linked Naphthylisoquinoline Alkaloid Ancistrocladidine", Bungard, C. J.; Morris, J. C. J. Org. Chem. 2006, 71, 7354-7363. "Discovery of New Classes of Brugia malayi Asparaginyl tRNA Synthetase Inhibitors and Relating Selectivity to Conformational Change" Sukuru, S. C. K.; Crepin, T.; Morris, J. C.; Hill, J. B.; Anderson, R. J.; Marsh. L. C.; Grøtli, M.; Danel, F.; Milev, Y.; Page, M. G. P.; Cusack, S.; Kron, M. A.; Kuhn, L. A., J. Comp.-Aided Molecular Design, 2006, 20, 159-178. "Concise Total Syntheses of Variolin B and Deoxyvariolin B", Anderson, R. J.; Hill, J. B.; Morris, J. C., J. Org. Chem., 2005, 70, 6204 -6212. "First Total Synthesis of the 7,3'-Linked Naphthylisoquinoline Alkaloid Ancistrocladidine", Bungard, C. J., Morris, J. C., Organic Lett., 2002, 4, 631-633. "Total Synthesis of Variolin B", Anderson, R. J.; Morris, J. C., Tetrahedron Lett. 2001, 42, 8697-8699.