高慧玲 - 东北大学 - 生命科学与健康学院

个人简介

国内工作经历 2013.06-至今东北大学生命科学与健康学院副教授教育经历 2009.09-2014.04 日本爱媛大学医学部解剖学与发生学博士 2004.09-2009.07 中国医科大学组织胚胎学博士 1999.09-2004.07 吉林大学医学部临床医学学士

研究领域

脑锌代谢与学习记忆以及神经退行性疾病发病机理的研究。应用小鼠和细胞模型，探讨金属离子及其转运体调节脑内金属离子代谢的分子机制

近期论文

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Xiaoyu Zhang, Manli Zhong, Pu Zhao, Xiancheng Zhang, You Li, Xuliang Wang, Jia Sun, Wang Lan, Hehong Sun, Zhanyou Wang*, Hui-ling Gao*. Screening a specific Zn(ii)-binding peptide for improving the cognitive decline of Alzheimer’s disease in APP/PS1 transgenic mice by inhibiting Zn2+-mediated amyloid protein aggregation and neurotoxicity.Biomater Sci. 2019 Oct 7. doi: 10.1039/c9bm00676a. Hui-ling Gao*, Cheng Li, Hiroaki Nabeka*, Tetsuya Shimokawa, Zhan-You Wang, Ya-ming Cao, Seiji Matsuda. An 18-mer Peptide Derived from Prosaposin Ameliorates the Effects of Aβ1-42 Neurotoxicity on Hippocampal Neurogenesis and Memory Deficit in Mice. J Alzheimers Dis. 2016 Jun 30;53(3):1173-92. doi: 10.3233/JAD-160093 Hui-ling Gao, Cheng Li, Hiroaki Nabeka*, Tetsuya Shimokawa, Naoto Kobayashi, Shouichiro Saito, Zhan-You Wang, Ya-ming Cao, and Seiji Matsuda. Decrease in prosaposin in the Dystrophic mdx mouse brain. PLoS One. 2013 Nov 14;8(11):e80032. doi: 10.1371/journal.pone.0080032. eCollection 2013. Hui-Ling Gao, Cheng Li, Nabeka Hiroaki*, Shimokawa Tetsuya, Saito Shouichiro, Zhan-You Wang, Ya-ming Cao, Seiji Matsuda. Attenuation of MPTP/MPP+ toxicity in vivo and in vitro by an 18-mer peptide derived from prosaposin. Neuroscience, doi: 10.1016/j.neuroscience.2013.01.007, 2013. Hui-Ling Gao, He Xu, Na Xin, Wei Zheng, Zhi-Hong Chi, Zhan-You Wang*. Disruption of the CaMKII/CREB signaling is associated with zinc deficiency-induced learning and memory impairments. Neurotoxicity Research, 19(4), 584–591, 2011. Hui-Ling Gao, Wei Zheng, Na Xin, Zhi-Hong Chi, Zhen-Yu Wang, Jie Chen, Zhan-You Wang*. Zinc deficiency reduces neurogenesis accompanied by neuronal apoptosis through caspase-dependent and -independent signaling pathways. Neurotoxicity Research, 16(4), 416-425, 2009. Hui-Ling Gao, Wan-Yu Feng, He Xu, Liping Huang, Zhan-You Wang*. Golgi apparatus localization of ZNT7 in the mouse cerebellum. Histology and Histopathology, 24(5), 567-572, 2009. Hui-Ling Gao, Xin Wang, Wei Zheng, Annica Dahlstrom, Liping Huang, Zhan-You Wang*. Expression of zinc transporter ZnT7 in mouse superior cervical ganglion. Autonomic Neuroscience, 140(1-2), 59-65, 2008. Cheng Li, Hui-Ling Gao, Tetsuya Shimokawa*, Hiroaki Nabeka, Fumihiko Hamada, Hiroaki Araki, Ya-ming Cao, Naoto Kobayashi, Seiji Matsuda. Prosaposin expression in the regenerated muscles of mdx and cardiotoxin-treated mice. Histology and Histopathology, in press, 2013 Jan 17. [Epub ahead of print], 2013. He Xu, Hui-Ling Gao, Wei Zheng, Na Xin, Zhi-Hong Chi, Shu-Ling Bai, Zhan-You Wang*. Lactational zinc deficiency-induced hippocampal neuronal apoptosis by a BDNF-independent TrkB signaling pathway. Hippocampus, 21(5), 495-501, 2011. Tian-Shu Sun,Xiao Ju,Hui-Ling Gao,Tao Wang,Dennis J. Thiele,Jia-Yi Li, Zhan-You Wang, Chen Ding. Reciprocal functions of Cryptococcus neoformans copper homeostasis machinery during pulmonary infection and meningoencephalitis. Nat Commun. 2014 Nov 24;5:5550. doi: 10.1038/ncomms6550. Bing Xue, Jie Chen*, Hui-ling Gao, Shouichiro Saito, Naoto Kobayashi, Tetsuya Shimokawa, Hiroaki Nabeka, Akira Sano, Seiji Matsuda. Chronological changes in prosaposin in the developing rat brain. Neuroscience Research, 71(1), 22-34, 2011. Xue-Jiao Zhang, Cheng Li,Hui-ling Gao, Hiroaki Nabeka, Tetsuya Shimokawa, Hiroyuki Wakisaka, Seiji Matsuda, Naoto Kobayashi*. Rho kinase inhibitors stimulate the migration of human cultured osteoblastic cells by regulating actomyosin activity. Cell Molecular Biology Letter, 16(2), 279-295, 2011. Zhi-Hong Chi, Wan-Yu Feng, Hui-Ling Gao, Wei Zheng, Liping Huang, Zhan-You Wang*. ZnT7 and Zn2+ are present in different cell populations in the mouse testis. Histology and Histopathology, 24(1), 25-30, 2009.