李莉娅 - 东北大学 - 生命科学与健康学院

个人简介

1996.09-2000.07 北京大学医学部药学专业，理学学士 2000.09-2003.07 北京大学医学部药物化学专业，理学硕士 2003.09-2006.07 北京大学医学部生药学专业，理学博士 2006.08-2008.04 首都医科大学中医药学院，讲师 2008.05-2013.07 美国罗德岛大学药学院，博士后 2013.08-至今东北大学生命科学与健康学院，副教授

研究领域

1. 药食两用植物天然活性成分的挖掘及作用机制研究 2. 食品功能因子分析鉴定及生物学功能探索

近期论文

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1. Wang, G.; Xu, J.; Ma, H.; Mu, Y.; Xu, W.; Yan, N.; Liu, W.; Zheng, D.; Huang, X.; Li, L.* Phenolipid JE improves metabolic profile and inhibits gluconeogenesis via modulating AKT-mediated insulin signaling in STZ-induced diabetic mice. Pharmacol. Res. 187, 106569, 2023. 2. Xu, W.; Li, J.; Chen, J.; Xu, J.; Zheng, D.; Wu, M.; Mu, Y.; Huang, X.; Li, L.* Discovery, preparation and characterization of lipid-lowering alkylphenol derivatives from Syzygium jambos fruit. Food Chem. 396, 133668, 2022. 3. Liu, W.; Li, M.; Wang, G.; Ma, H.; Mu, Y.; Zheng, D.; Huang, X.; Li, L.* New monoterpene acid and gallic acid glucose esters with anti-inflammatory activity from blue gum (Eucalyptus globulus) leaves. J. Agric. Food Chem. 69(12), 3626-3637, 2022. 4. Li, Y.; Bai, D.; Lu, Y.; Chen, J.; Yang, H.; Mu, Y.; Xu, J.; Li, D.; Ma, H.; Mu, Y.; Huang, X.; Li, L.* The crude guava polysaccharides ameliorate high-fat diet-induced obesity in mice via reshaping gut microbiota. Int. J. Biol. Macromol. 213, 234-246, 2022. 5. Li. D.; Xu, Z.; Li, Y.; Gan, L.; Wu, P.; Wu, R.; Jin, J.; Zheng, X.; Zhang, K.; Ma, H.*; Li, L.* Polysaccharides from Callerya speciosa alleviate metabolic disorders and gut microbiota dysbiosis in diet-induced obese C57BL/6 mice. Food Funct., 13(16), 8662-8675, 2022. 6. Li, Y.; Xu, J.; Li, D.; Ma, H.; Mu, Y.; Zheng, D.; Huang, X.*; Li, L.* Chemical characterization and hepatoprotective effects of a standardized triterpenoids-enriched guava leaf extract. J. Agric. Food Chem. 69(12), 3626-3637, 2021. 7. Xu, W.; Tan, J.; Mu, Y.; Zheng, D.; Huang, X.*; Li, L.* New antimicrobial terpenoids and phloroglucinol glucosides from Syzygium szemaoense. Bioorg. Chem. 103, 104242, 2020. 8. Li, Y.; Xu, J.; Li, D.; Ma, H.; Mu, Y.; Huang, X.*; Li, L.* Guavinoside B from Psidium guajava alleviates acetaminophen-induced liver injury via regulating Nrf2 and JNK signaling pathways. Food Funct., 11, 8297-8308, 2020. 9. Li, L. #; Ma, H. #; Liu, T.; Ding, Z.; Liu, W.; Gu, Q.; Mu, Y.; Xu, J.; Seeram, N. P.*; Huang, X.*; Xu, J.* Glucitol-core containing gallotannins-enriched red maple (Acer rubrum) leaves extract alleviated obesity via modulating short-chain fatty acid production in high-fat diet-fed mice. J. Funct. Foods, 70(7), 103970, 2020. 10. Xu, J.; Liu, T.; Li, Y.; Liu, W.; Ding, Z.; Ma, H.; Seeram, N. P.; Mu, Y.; Huang, X.*; Li, L.* Jamun (Eugenia jambolana Lam.) fruit extract prevents obesity by modulating the gut microbiome in high-fat diet-fed mice. Mol. Nutr. Food Res., 63(9), 1801307, 2019. 11. Li, Y.; Li, D.; An, Q.; Ma, H.; Mu, Y.; Qiao, W.; Zhang, Z.; Zhang, J.; Huang, X. *; Li, L.* New acylated phenolic glycosides with ROS scavenging activity from Psidium guajava leaves. J. Agric. Food Chem. 67(40), 11089-11098, 2019. 12. Xu, J.; Liu, T.; Li, Y.; Yuan, C.; Ma, H.; Seeram, N. P; Liu, F.; Mu, Y.; Huang, X.*; Li, L.* Hypoglycemic and hypolipidemic effects of triterpenoid-enriched jamun (Eugenia jambolana Lam.) fruit extract in streptozotocin-induced type 1 diabetic mice. Food Funct. 9(6), 3330-3337, 2018. 13. Liu, F.; Ma, H.; Wang, G.; Liu, W.; Seeram, N. P; Mu, Y.; Xu, Y.; Huang, X.*; Li, L.* Phenolics from Eugenia jambolana seeds with advanced glycation endproducts formation and alpha-glucosidase inhibitory activities. Food Funct. 9(8), 4246-4245, 2018. 14. Xu, J.; Yuan, C.; Wang, G.; Luo, J.; Ma, H.; Xu, L.; Mu, Y.; Li, Y.; Seeram, N. P*; Huang, X.*; Li, L.* Urolithins attenuate LPS-induced neuroinflammation in BV2 microglia via MAPK, Akt and NF-кB signaling pathways. J. Agric. Food Chem. 66(3), 571-580, 2018. 15. Liu, F.; Liu, C.; Liu, W.; Ding, Z.; Ma, H.; Seeram, N. P; Xu, L.; Mu, Y.; Huang, X.*; Li, L.* New Sesquiterpenoids from Eugenia jambolana seeds and their anti-microbial activities. J. Agric. Food Chem. 65(47), 10214-10222, 2017. 16. Li, Y.; Xu, J.; Yuan, C.; Ma, H.; Liu, T.; Liu, F.; Seeram, N. P.; Mu, Y.; Huang, X.*; Li, L.* Chemical composition and anti-hyperglycaemic effects of triterpenoid enriched Eugenia jambolana Lam. berry extract. J. Funct. Foods, 28(1), 1-10, 2017. 17. Liu, F.; Yuan, T.; Liu, W.; Ma, H.; Seeram, N. P.; Li, Y.; Xu, L.; Mu, Y.; Huang, X.*; Li, L.* Phloroglucinol derivatives with protein tyrosine phosphatase 1B inhibitory activities from Eugenia jambolana seeds. J. Nat. Prod. 80(2), 544-550, 2017. 18. Li, L.; Xu, J.; Mu, Y.; Han, L.; Liu, R.; Cai, Y.; Huang, X.* Chemical characterization and anti-hyperglycaemic effects of polyphenol enriched longan (Dimocarpus longan Lour.) pericarp extracts. J. Funct. Foods, 13(1), 314-322, 2015.