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个人简介

黄学石,博士,教授,博士研究生导师。现工作于东北大学生命科学与健康学院微生物药物研究所。1997年北京医科大学获得药学学士学位;2002年中国协和医科大学获药物化学博士学位,同年赴德国Hans Knoell研究所从事微生物药物研究工作。2005年作为人才引进回国工作;2012年入选“教育部新世纪优秀人才计划”。迄今为止获得多项国家和省部级课题资助;在国际期刊《Angew Chem》、《J Med Chem》、《J Nat Prod》、《Bioorg Chem》、《Org Chem Front》等发表SCI收录文章130余篇,参编专著2部,获批国内外发明专利8项。

研究领域

1.天然活性物质挖掘和作用机制研究 2.活性小分子全合成和构效关系研究

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1. Zhang, Z.; Xu, W.; Xu, L.; Li, G.; Aobulikasimu, N.; Gao, J.; Hu, Y.; Guan, P.; Mu, Y.; Huang, X.*; Han, L.*, Discovery, preliminary structure-activity relationship, and evaluation of oleanane-type saponins from Pulsatilla chinensis for the treatment of ulcerative colitis. Journal of Medicinal Chemistry 2023, 66(5), 3635-3647. 2. Li, L.#; Fan, Y.#; Wu, W.#; Bai, C.; Jia, M.; Hu, J.; Gao, H.; Wang, T.; Zhong, M.; Huang, X.*; Guo, C.*, Novel melatonin-trientine conjugate as potential therapeutic agents for Alzheimer’s disease. Bioorganic Chemistry 2022, 128. 106100 3. Hu, C.; Li, G.; Mu, Y.; Wu, W.; Cao, B.; Wang, Z.; Yu, H.; Guan, P.; Han, L.*; Li, L.*; Huang, X.*, Discovery of anti-TNBC agents targeting PTP1B: total synthesis, structure-activity relationship, in vitro and in vivo investigations of jamunones. Journal of Medicinal Chemistry 2021, 64 (9), 6008-6020. 4. Cao, L.; Guan, P.; Zhang, S.; Yang, Y.; Huang, X.*; Wang, P.*, Downregulating expression of OPTN elevates neuroinflammation via AIM2 inflammasome- and RIPK1-activating mechanisms in APP/PS1 transgenic mice. Journal of neuroinflammation 2021, 18 (1), 281. 5. Guan, P.; Wang, X.; Jiang, Y.*; Dou, N.; Qu, X.; Liu, J.; Lin, B.; Han, L.; Huang, X.*; Jiang, C., The anti-inflammatory effects of jiangrines from Jiangella alba through inhibition of p38 and NF-kappaB signaling pathways. Bioorganic Chemistry 2020, 95, 103507. 6. Gao, X.; Yao, H.; Mu, Y.; Guan, P.; Li, G.; Lin, B.; Jiang, Y.*; Han, L.*; Huang, X.*; Jiang, C., The antiproliferative effect of spectinabilins from Streptomyces spectabilis on hepatocellular carcinoma cells in vitro and in vivo. Bioorganic Chemistry 2019, 93, 103311. 7. Liu, Q.; Han, L.*; Qin, B.; Mu, Y.; Guan, P.; Wang, S.; Huang, X.*, Total synthesis of (±)-(1β,4β,4aβ,8aα)-4,8a-dimethyl-octahydro-naphthalene-1,4a(2H)-diol. Organic Chemistry Frontiers 2018, 5 (10), 1719-1723. 8. Liu, F.; Yuan, T.; Liu, W.; Ma, H.; Seeram, N. P.; Li, Y.; Xu, L.; Mu, Y.; Huang, X.*; Li, L.*, Phloroglucinol derivatives with protein tyrosine phosphatase 1B inhibitory activities from Eugenia jambolana seeds. Journal of Natural Products 2017, 80 (2), 544-550. 9. Liu, F.; Liu, C.; Liu, W.; Ding, Z.; Ma, H.; Seeram, N. P.; Xu, L.; Mu, Y.; Huang, X.*; Li, L.*, New sesquiterpenoids from Eugenia jambolana seeds and their anti-microbial activities. Journal of Agricultural and Food Chemistry 2017, 65 (47), 10214-10222. 10. Zheng, D.#; Han, L.#; Qu, X.; Chen, X.; Zhong, J.; Bi, X.; Liu, J.; Jiang, Y.*; Jiang, C.; Huang, X.*, Cytotoxic fusicoccane-type diterpenoids from Streptomyces violascens isolated from Ailuropoda melanoleuca Feces. Journal of Natural Products 2017, 80 (4), 837-844. 11. Ding, N.; Jiang, Y.; Han, L.; Chen, X.; Ma, J.; Qu, X.; Mu, Y.; Liu, J.; Li, L.; Jiang, C.; Huang, X.*, Bafilomycins and odoriferous sesquiterpenoids from Streptomyces albolongus isolated from Elephas maximus feces. Journal of Natural Products 2016, 79 (4), 799-805. 12. Li, L.; Xu, J.; Mu, Y.; Han, L.; Liu, R.; Cai, Y.; Huang, X.*, Chemical characterization and antihyperglycaemic effects of polyphenol enriched longan (Dimocarpus longan Lour.) pericarp extracts. Journal of Functional Foods 2015, 13, 314-322. 13. Zhang, J.; Jiang, Y.; Cao, Y.; Liu, J.; Zheng, D.; Chen, X.; Han, L.; Jiang, C.; Huang, X.*, Violapyrones A-G, alpha-pyrone derivatives from Streptomyces violascens isolated from Hylobates hoolock feces. Journal of Natural Products 2013, 76 (11), 2126-30. 14. Huang, X.; He, J.; Niu, X.; Menzel, K. D.; Dahse, H. M.; Grabley, S.; Fiedler, H. P.; Sattler, I.*; Hertweck, C.*, Benzopyrenomycin, a cytotoxic bacterial polyketide metabolite with a benzo[a]pyrene-type carbocyclic ring system. Angewandte Chemie International Edition 2008, 47 (21), 3995-8. 15. Huang, X.; Roemer, E.; Sattler, I.; Moellmann, U.; Christner, A.; Grabley, S.*, Lydiamycins A-D: cyclodepsipetides with antimycobacterial properties. Angewandte Chemie International Edition 2006, 45 (19), 3067-72.

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