盛韧 - 东北大学 - 生命科学与健康学院

个人简介

2004.8-2008.7 吉林大学化学学院，化学学士 2008.8-2013.12 University of Illinois at Chicago, 化学博士 2014.1-2015.4 University of Illinois at Chicago, 博士后研究员 (with Dr. Wonhwa Cho) 2015.5-2018.7 Harvard Medical School/Boston Children’s Hospital, 博士后研究员 (with Dr. Xi He) 2018.8至今东北大学生命科学与健康学院，教授、博士生导师、独立PI、课题组组长

研究领域

细胞生物学、肿瘤生物学、化学生物学

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. USP10 strikes down β-catenin by dual-wielding deubiquitinase activity and phase separation potential.Wang Y#, Mao A#, Liu J#, Li P#, Zheng S, Tong T, Li Z, Zhang H, Ma L, Lin J, Pang Z, Han Q, Qi F, Zhang X, Chen M, He X, Zhang XJ, Fei T, Liu B, Gao D, Cao L*, Wang Q*, Li Y*, Sheng R*. Cell Chemical Biology, 2023 Aug 11;S2451-9456(23)00246-5. 2. Anti-pan-Rspo chimeric protein-conjugated albumin nanoparticle provides promising opportunities in cancer targeted therapy.Zheng S#, Zhang X#, Pang Z, Liu J, Liu SY*, Sheng R*. Advanced Healthcare Materials, 2023 Jul 6;e2301441. 3. Aberrant cholesterol metabolism and Wnt/β-catenin signaling coalesce via Frizzled5 in supporting cancer growth.Zheng S, Lin J, Pang Z, Zhang H, Wang Y, Ma L, Zhang H, Zhang X, Chen M, Zhang XJ, Zhao C, Qi J, Cao L, Wang M*, He X*, Sheng R*. Advanced Science, 2022 Oct;9(28):e2200750. 4. CDKL3 promotes osteosarcoma progression by activating Akt/PKB.He A#*, Ma L#, Huang Y#, Zhang H, Duan W, Li Z, Fei T, Huang W, Wu H, Liu L, Yuan J, Bai Y, Dai W, Wang Y, Li H, Sun Y, Wang Y, Wang C, Yuan T, Yang Q, Tian S, Dong M, Sheng R*, Xiang D*. Life Science Alliance, 2020 Mar 31;3(5). 5. Orthogonal lipid sensors identify transbilayer asymmetry of plasma membrane cholesterol.Liu SL#, Sheng R#, Jung JH, Wang L, Stec E, O’Connor MJ, Song S, Bikkavilli RK, Winn R, Lee D, Baek K, Ueda K, Levitan I, Kim KP, Cho W*. Nature Chemical Biology, 2017 Mar;13(3):268-274. 6. Lipids regulate Lck activity through their interactions with the Lck SH2 domain.Sheng R#, Jung DJ#, Silkov A, Kim H, Wang ZG, Xin Y, Kim E, Park MJ, Thiagarajan-Rosenkranz P, Honig B, Beak K, Ryu S, Lorieau J, Kim YM*, Cho W*. Journal of Biological Chemistry, 2016 Aug 19;291(34):17639:50. 7. SH2 domains serve as lipid-binding modules for pTyr-Signaling proteins.Park MJ#, Sheng R#, Silkov A#, Jung DJ, Wang ZG, Xin Y, Kim H, Thiagarajan-Rosenkranz P, Song S, Yoon Y, Nam W, Kim I, Kim E, Lee DG, Chen Y, Singaram I, Wang L, Jang MH, Hwang CS, Honig B, Ryu S, Lorieau J, Kim YM*, Cho W*. Highlighted by Cell (04/2016), Nature Review in Molecular Cell (05/2016), Cancer Discovery (04/2016) and F1000Prime (04/2016) Molecular Cell, 2016 Apr 7; 62(1): 7-20. 8. Cholesterol selectively activates canonical Wnt signalling over non-canonical Wnt signalling.Sheng R#, Kim H#, Lee H#, Xin Y, Chen Y, Tian W, Cui Y, Choi JC, Doh J, Han JK*, Cho W*. Nature Commununications, 2014; 5:4393. 9. Cholesterol modulates cell signaling and protein networking by specifically interacting with scaffold proteins.Sheng R#, Chen Y#, Yung Gee H, Stec E, Melowic HR, Blatner NR, Tun MP, Kim Y, Källberg M, Fujiwara TK, Hye Hong J, Pyo Kim K, Lu H, Kusumi A, Goo Lee M, Cho W*. Nature Communications, 2012;3:1249. 10. Genome-wide identification and functional annotation of dual specificity protein- and lipid-binding modules that modulate protein interactions at the membrane.Chen Y#, Sheng R#, Kallberg M#, R. Silkov A, Tun MP, Bhardwaj N, Kurilova S, Hall RA, Honig B, Lu H*, and Cho W*. Molecular Cell, 2012 Apr 27;46(2):226-37.