郝爽 - 东北大学 - 生命科学与健康学院

个人简介

郝爽，博士，教授，博士生导师。现就职于东北大学生命科学与健康学院分子医学研究所。（人才称号：国家级青年人才项目，兴辽英才项目青年拔尖人才、东北大学海外百人青年特聘教授）（任职：中国神经科学学会神经调控分会委员、辽宁省生命科学学会神经病学分会副主任委员）（个人评价：课题组主要研究方向集中在光、电等物理性神经调控技术对脑重大疾病的调节作用及机制研究。将神经病学、神经生物学等基础研究与临床治疗相结合，采用多学科交叉融合的方法揭示神经发育障碍、神经退行性疾病等神经系统疾病的发病机制，探讨脑深部电刺激、红外光刺激等可在临床推广应用的物理性神经调控治疗方法的可行性和治疗机制，为实现脑疾病的精准医疗提供理论和实践支持。经过多年努力，在Nature、Cell、Neuron以及Journal of Neuroscience等国际顶级刊物上发表多篇论文。）（教授课程：本科生课程：科学文献阅读与写作、现代生物学前言热点解析、人体解剖生理学；研究生课程：全英文课程Neurophysiology: A conceptual approach、全英文课程Neuroscience: Exploring the Brain、论文写做指导（研究生必修课））等。教育和工作经历 2002.09-2006.06 河北工业大学生物工程，工学学士 2006.09-2012.04 大连理工大学，生物化工，工学博士 2012.07-2019 美国贝勒医学院，神经病学，博士后

研究领域

1. 孤独症谱系罕见病的神经环路机制研究 2. 光、电等物理性神经调控的调节作用及作用机制研究 3. 胶质瘤免疫微环境对肿瘤进程调节作用研究

近期论文

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Qi Wang#, Bin Tang#, Shuang Hao#, Zhenyu Wu, Tingting Yang, Jianrong Tang. Forniceal deep brain stimulation in a mouse model of Rett syndrome increases neurogenesis and hippocampal memory beyond the treatment period. 2023, Brain stimulation. Brain stimulation. 16: 1401-1411.（共同一作） Shuang Hao#, Qi Wang#, Bin Tang, Zhenyu Wu, Tingting Yang, Jianrong Tang. CDKL5 deficiency augments inhibitory input into the dentate gyrus that can be reversed by deep brain stimulation. 2021. Journal of Neuroscience. 41: 9031-9046. Shuang Hao, Bin Tang, Zhenyu Wu, Kerstin Ure, Yaling Sun, Huifang Tao, Yan Gao, Akash J. Patel, Daniel J. Curry, Rodney C. Samaco, Huda Y. Zoghbi & Jianrong Tang. 2015. Forniceal deep brain stimulation rescues hippocampal memory in Rett syndrome mice. Nature. 526: 430-434. Wu Chen, Zhao-Lin Cai, Eugene S Chao, Hongmei Chen, Colleen M Longley, Shuang Hao, Hsiao-Tuan Chao, Joo Hyun Kim, Jessica E Messier, Huda Y Zoghbi, Jianrong Tang, John W Swann, Mingshan Xue. 2020. Stxbp1/Munc18-1 haploinsufficiency impairs inhibition and mediates key neurological features of STXBP1 encephalopathy. eLIFE. DOI: 10.7554/eLife.48705. Vincenzo A. Gennarino, Elizabeth E. Palmer, Laura M. McDonell, Li Wang, Carolyn J. Adamski, Christian P. Schaaf, Jill A. Rosenfeld, Jessica A. Panzer, Ute Moog, Shuang Hao, Ann Bye, Edwin P. Kirk, Pawel Stankiewicz, Amy M. Breman, Arran McBride, Tejaswi Kandula, Holly A. Dubbs, Rebecca Macintosh, Michael Cardamone, Ying Zhu, Kevin Ying, Kerith-Rae Dias, Megan T. Cho, Lindsay B. Henderson, Berivan Baskin, Paula Morris, Jiang Tao, Mark J. Cowley, Marcel E. Dinger, Tony Roscioli, Oana Caluseriu, Oksana Suchowersky, Rani K. Sachdev, Olivier Lichtarge, Jianrong Tang, Kym M. Boycott, J. Lloyd Holder, Jr., and Huda Y. Zoghbi. 2018. A Mild PUM1 Mutation Is Associated with Adult-Onset Ataxia, whereas Haploinsufficiency Causes Developmental Delay and Seizures. Cell. 172: 924-936. Amy E Pohodich, Hari Yalamanchili, Ayush T Raman, Ying-Wooi Wan, Michael Gundry, Shuang Hao, Haijing Jin, Jianrong Tang, Zhandong Liu, Huda Y Zoghbi. 2018, Forniceal deep brain stimulation induces gene expression and splicing changes that promote neurogenesis and plasticity. eLIFE. DOI: 10.7554/eLife.34031. James P. Orengo, Meike E. van der Heijden, Shuang Hao, Jianrong Tang, Harry T. Orr, and Huda Y. Zoghbi. 2018. Motor neuron degeneration correlates with respiratory dysfunction in SCA1. Dis Model Mech. DOI: 10.1242/dmm.032623. Cristian A. Lasagna-Reeves, Maria de Haro, Shuang Hao, Jeehye Park, Maxime W.C. Rousseaux, Ismael Al-Ramahi, Paymaan Jafar-Nejad, Luis Vilanova-Velez, Lauren See, Antonia De Maio, Larissa Nitschke, Zhenyu Wu, Juan C. Troncoso, Thomas F. Westbrook, Jianrong Tang, Juan Botas and Huda Y. Zoghbi. 2016. Reduction of Nuak1 Decreases Tau And Reverses Phenotypes in a Tauopathy Mouse Model. Neuron. 92: 407-418. Hui Lu, Ryan T. Ash, Lingjie He, Sara E. Kee, Wei Wang, Dinghui Yu, Shuang Hao, Xiangling Meng, Kerstin Ure, Yaling Sun, Daoyun Ji, Jiangrong Tang, Benjamin R. Arenkiel, Stelios M. Smirnakis, and Huda Y. Zoghbi. 2016. Loss and gain of MeCP2 lead to similar hippocampal circuit abnormalities that are rescued by deep brain stimulation in a Rett syndrome mouse model. Neuron. 91: 739-747. Yehezkel Sztainberg, Hong-mei Chen, John W. Swann, Shuang Hao, Bin Tang, Zhenyu Wu, Jianrong Tang, Ying-Wooi Wan, Zhandong Liu, Frank Rigo & Huda Y. Zoghbi. 2015. Reversal of phenotypes in MECP2 duplication mice using genetic rescue or antisense oligonucleotides. Nature. 528: 123-126. Kihoon Han, J. Lloyd Holder, Jr, Christian P. Schaaf, Hui Lu, Hongmei Chen, Hyojin Kang, Jianrong Tang, ZhenyuWu, Shuang Hao, SauWai Cheung, Peng Yu, Hao Sun, Amy M. Breman, Ankita Patel, Hui-Chen Lu & Huda Y. Zoghbi. 2013. SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties. Nature. 503: 72-77. Shuang Hao, Yong-Ming Bao, Li- Jia An, Wei Cheng, Rong-Guo Zhao, Jing Bi, He- Shuang Wang, Chang- Sen Sun, Ji-Wen Liu, Bo Jiang. 2011. Effects of Resibufogenin and Cinobufagin on voltage-gated potassium channels in primary cultures of rat hippocampal neurons. Toxicol in Vitro. 25: 1644-1653. Shuang Hao, Yong-Ming Bao, Rong-Guo Zhao, He-Shuang Wang, Jing Bi, Li- jia An, Bo Jiang. 2011. Effects of Resibufogenin on voltage-gated sodium channels in cultured rat hippocampal neurons. Neurosci Lett. 501: 112-116.