刘弘光 - 东北大学 - 生命科学与健康学院

个人简介

刘弘光博士，教授。 2003年毕业于中国医科大学临床医学专业，2003-2006年在中国医科大学发育生物学系获硕士学位，2007-2010年在北京协和医学院放射医学研究所学习获博士学位。攻读博士期间，2008至2010年在美国斯坦福大学分子影像中心进修。2010年至2012年在斯坦福大学医学院分子影像中心做博士后，从事分子探针和药物的设计及评价、癌症检测和治疗、以及生物纳米技术等研究。2013年至今，在东北大学生命科学与健康学院工作。在SCI收录期刊发表论文70余篇。

研究领域

1.主要从事分子影像学前沿技术和肿瘤靶向分子探针的研发 2.NIR-II光学成像：NIR-II成像方法和前沿技术的研发与转化 3.分子探针：设计、合成和体内外评价分子探针 4.肿瘤放射靶向治疗：利用治疗性核素标记靶向探针用于治疗肿瘤

近期论文

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[1] X. Wu, Y. Suo, H. Shi, R. Liu, F. Wu, T. Wang, L. Ma, H. Liu, Z. Cheng, Deep-Tissue Photothermal Therapy Using Laser Illumination at NIR-IIa Window, Nano-Micro Letters 12(1) (2020) 38. [2] Y. Suo, F. Wu, P. Xu, H. Shi, T. Wang, H. Liu, Z. Cheng, NIR-II Fluorescence Endoscopy for Targeted Imaging of Colorectal Cancer, Advanced Healthcare Materials 8(23) (2019) 1900974. [3] Y. Zhang, N. Zhao, Y. Qin, F. Wu, Z. Xu, T. Lan, Z. Cheng, P. Zhao, H. Liu, Affibody-functionalized Ag2S quantum dots for photoacoustic imaging of epidermal growth factor receptor overexpressed tumors, Nanoscale 10(35) (2018) 16581-16590. [4] E. Lucente, H. Liu, Y. Liu, X. Hu, E. Lacivita, M. Leopoldo, Z. Cheng, Novel (64)Cu Labeled RGD2-BBN Heterotrimers for PET Imaging of Prostate Cancer, Bioconjug Chem 29(5) (2018) 1595-1604. [5] N. Zhao, Y. Qin, H. Liu, Z. Cheng, Tumor-targeting peptides: ligands for molecular imaging and therapy, Anti-cancer agents in medicinal chemistry (2017). [6] L. Zu, L. Liu, Y. Qin, H. Liu, H. Yang, Multifunctional BSA-Au nanostars for photoacoustic imaging and X-ray computed tomography, Nanomedicine: Nanotechnology, Biology and Medicine (2016). [7] N. Zhao, Y. Pan, H. Liu, Z. Cheng, Draft genome sequence of Zymomonas mobilis ZM481 (ATCC 31823), Genome announcements 4(2) (2016) e00193-16. [8] N. Zhao, Y. Pan, Z. Cheng, H. Liu, Lasso peptide, a highly stable structure and designable multifunctional backbone, Amino acids 48(6) (2016) 1347-1356. [9] N. Zhao, Y. Pan, Z. Cheng, H. Liu, Gold nanoparticles for cancer theranostics: A brief update, Journal of Innovative Optical Health Sciences (2016) 1630004. [10] N. Zhao, S. Liu, Q. Jiang, T. Lan, Z. Cheng, H. Liu, Small‐Protein‐Stabilized Semiconductor Nanoprobe for Targeted Imaging of Cancer Cells, ChemBioChem (2016). [11] S. Liu, H. Wang, Z. Cheng, H. Liu, Hexametaphosphate-capped quantum dots as fluorescent probes for detection of calcium ion and fluoride, Sensors and Actuators B: Chemical 232 (2016) 306-312. [12] S. Liu, N. Zhao, Z. Cheng, H. Liu, Amino-functionalized green fluorescent carbon dots as surface energy transfer biosensors for hyaluronidase, Nanoscale 7(15) (2015) 6836-42. [13] S. Liu, H. Wang, Z. Cheng, H. Liu, Facile synthesis of near infrared fluorescent trypsin-stabilized Ag nanoclusters with tunable emission for 1,4-dihydronicotinamide adenine dinucleotide and ethanol sensing, Anal Chim Acta 886 (2015) 151-6. [14] M.L. James, N.P. Belichenko, T.-V.V. Nguyen, L.E. Andrews, Z. Ding, H. Liu, D. Bodapati, N. Arksey, B. Shen, Z. Cheng, PET Imaging of Translocator Protein (18 kDa) in a Mouse Model of Alzheimer's Disease Using N-(2, 5-Dimethoxybenzyl)-2-18F-Fluoro-N-(2-Phenoxyphenyl) Acetamide, Journal of Nuclear Medicine 56(2) (2015) 311-316. [15] E. Chang, H. Liu, K. Unterschemmann, P. Ellinghaus, S. Liu, V. Gekeler, Z. Cheng, D. Berndorff, S.S. Gambhir, 18F-FAZA PET imaging response tracks the reoxygenation of tumors in mice upon treatment with the mitochondrial complex I inhibitor BAY 87-2243, Clinical Cancer Research 21(2) (2015) 335-346. [16] X. Zhu, J. Li, Y. Hong, R.H. Kimura, X. Ma, H. Liu, C. Qin, X. Hu, T.R. Hayes, P. Benny, 99mTc-labeled cystine knot peptide targeting integrin αvβ6 for tumor SPECT imaging, Molecular pharmaceutics 11(4) (2014) 1208-1217. [17] X. Yang, H. Liu, C.K. Sun, A. Natarajan, X. Hu, X. Wang, M. Allegretta, R.D. Guttmann, S.S. Gambhir, M.-S. Chua, Imaging of hepatocellular carcinoma patient-derived xenografts using 89 Zr-labeled anti-glypican-3 monoclonal antibody, Biomaterials 35(25) (2014) 6964-6971. [18] C. Qin, H. Liu, K. Chen, X. Hu, X. Ma, X. Lan, Y. Zhang, Z. Cheng, Theranostics of malignant melanoma with 64CuCl2, Journal of Nuclear Medicine 55(5) (2014) 812-817. [19] F.M. Lartey, G.-O. Ahn, B. Shen, K.-T. Cord, T. Smith, J.Y. Chua, S. Rosenblum, H. Liu, M.L. James, S. Chernikova, PET imaging of stroke-induced neuroinflammation in mice using [18F] PBR06, Molecular Imaging and Biology 16(1) (2014) 109-117. [20] F.M. Lartey, G.-O. Ahn, R. Ali, S. Rosenblum, Z. Miao, N. Arksey, B. Shen, M.V. Colomer, M. Rafat, H. Liu, The relationship between serial [18 F] PBR06 PET imaging of microglial activation and motor function following stroke in mice, Molecular Imaging and Biology 16(6) (2014) 821-829. [21] B.B. Kasten, X. Ma, H. Liu, T.R. Hayes, C.L. Barnes, S. Qi, K. Cheng, S.C. Bottorff, W.S. Slocumb, J. Wang, Clickable, hydrophilic ligand for fac-[MI (CO) 3]+(M= Re/99mTc) applied in an S-functionalized α-MSH peptide, Bioconjugate chemistry 25(3) (2014) 579-592. [22] X. Hu, Q. Wang, Y. Liu, H. Liu, C. Qin, K. Cheng, W. Robinson, B.D. Gray, K.Y. Pak, A. Yu, Optical imaging of articular cartilage degeneration using near-infrared dipicolylamine probes, Biomaterials 35(26) (2014) 7511-7521. [23] K. Cheng, S.-R. Kothapalli, H. Liu, A.L. Koh, J.V. Jokerst, H. Jiang, M. Yang, J. Li, J. Levi, J.C. Wu, Construction and validation of nano gold tripods for molecular imaging of living subjects, Journal of the American Chemical Society 136(9) (2014) 3560-3571. [24] C.M. Carpenter, X. Ma, H. Liu, C. Sun, G. Pratx, J. Wang, S.S. Gambhir, L. Xing, Z. Cheng, Cerenkov Luminescence Endoscopy: Improved Molecular Sensitivity with β−-Emitting Radiotracers, Journal of Nuclear Medicine 55(11) (2014) 1905-1909. [25] L. Bu, R. Li, H. Liu, W. Feng, X. Xiong, H. Zhao, D. Vollrath, B. Shen, Z. Cheng, Intrastriatal transplantation of retinal pigment epithelial cells for the treatment of Parkinson disease: in vivo longitudinal molecular imaging with 18F-P3BZA PET/CT, Radiology 272(1) (2014) 174-183. [26] P. Zhao, X. Yang, S. Qi, H. Liu, H. Jiang, S. Hoppmann, Q. Cao, M.-S. Chua, S.K. So, Z. Cheng, Molecular imaging of hepatocellular carcinoma xenografts with epidermal growth factor receptor targeted affibody probes, BioMed research international 2013 (2013). [27] M. Yang, K. Cheng, S. Qi, H. Liu, Y. Jiang, H. Jiang, J. Li, K. Chen, H. Zhang, Z. Cheng, Affibody modified and radiolabeled gold–iron oxide hetero-nanostructures for tumor PET, optical and MR imaging, Biomaterials 34(11) (2013) 2796-2806. [28] C. Qin, K. Cheng, K. Chen, X. Hu, Y. Liu, X. Lan, Y. Zhang, H. Liu, Y. Xu, L. Bu, Tyrosinase as a multifunctional reporter gene for Photoacoustic/MRI/PET triple modality molecular imaging, Scientific reports 3 (2013). [29] M. Persson, H. Liu, J. Madsen, Z. Cheng, A. Kjaer, First 18 F-labeled ligand for PET imaging of uPAR: In vivo studies in human prostate cancer xenografts, Nuclear medicine and biology 40(5) (2013) 618-624. [30] A. Natarajan, F. Habte, H. Liu, A. Sathirachinda, X. Hu, Z. Cheng, C.M. Nagamine, S.S. Gambhir, Evaluation of 89Zr-rituximab tracer by Cerenkov luminescence imaging and correlation with PET in a humanized transgenic mouse model to image NHL, Molecular Imaging and Biology 15(4) (2013) 468-475. [31] Y. Liu, X. Hu, H. Liu, L. Bu, X. Ma, K. Cheng, J. Li, M. Tian, H. Zhang, Z. Cheng, A comparative study of radiolabeled bombesin analogs for the PET imaging of prostate cancer, Journal of nuclear medicine 54(12) (2013) 2132-2138. [32] H. Liu, S. Liu, Z. Miao, H. Jiang, Z. Deng, X. Hong, Z. Cheng, A Novel Aliphatic F-Labeled Probe for PET Imaging of Melanoma, Mol Pharm (2013). [33] H. Liu, S. Liu, Z. Miao, Z. Deng, B. Shen, X. Hong, Z. Cheng, Development of 18F-labeled picolinamide probes for PET imaging of malignant melanoma, J Med Chem 56(3) (2013) 895-901. [34] L. Jiang, Z. Miao, H. Liu, G. Ren, A. Bao, C.S. Cutler, H. Shi, Z. Cheng, 177Lu-labeled RGD-BBN heterodimeric peptide for targeting prostate carcinoma, Nuclear medicine communications 34(9) (2013) 909-914. [35] H. Jiang, S.J. Moore, S. Liu, H. Liu, Z. Miao, F.V. Cochran, Y. Liu, M. Tian, J.R. Cochran, H. Zhang, A novel radiofluorinated agouti-related protein for tumor angiogenesis imaging, Amino acids 44(2) (2013) 673-681. [36] B.J. Hackel, R.H. Kimura, Z. Miao, H. Liu, A. Sathirachinda, Z. Cheng, F.T. Chin, S.S. Gambhir, 18F-Fluorobenzoate–labeled cystine knot peptides for PET imaging of integrin αvβ6, Journal of Nuclear Medicine 54(7) (2013) 1101-1105. [37] F. Habte, G. Ren, T.C. Doyle, H. Liu, Z. Cheng, D.S. Paik, Impact of a multiple mice holder on quantitation of high-throughput micropet imaging with and without Ct attenuation correction, Molecular Imaging and Biology 15(5) (2013) 569-575. [38] Y. Xu, H. Liu, E. Chang, H. Jiang, Z. Cheng, Cerenkov Luminescence Imaging (CLI) for cancer therapy monitoring, JoVE (Journal of Visualized Experiments) (69) (2012) e4341-e4341. [39] Y. Xu, W. Huang, G. Ren, S. Qi, H. Jiang, Z. Miao, H. Liu, E. Lucente, L. Bu, B. Shen, A Four-Arm Star-Shaped Poly (ethylene glycol)(StarPEG) Platform for Bombesin Peptide Delivery to Gastrin-Releasing Peptide Receptors in Prostate Cancer, ACS Macro Letters 1(6) (2012) 753-757. [40] Y. Xu, E. Chang, H. Liu, H. Jiang, S.S. Gambhir, Z. Cheng, Proof-of-concept study of monitoring cancer drug therapy with Cerenkov luminescence imaging, Journal of Nuclear Medicine 53(2) (2012) 312-317. [41] J. Seo, G. Ren, H. Liu, Z. Miao, M. Park, Y. Wang, T.M. Miller, A.E. Barron, Z. Cheng, In vivo biodistribution and small animal PET of 64Cu-Labeled antimicrobial peptoids, Bioconjugate chemistry 23(5) (2012) 1069-1079. [42] G. Ren, J.M. Webster, Z. Liu, R. Zhang, Z. Miao, H. Liu, S.S. Gambhir, F.A. Syud, Z. Cheng, In vivo targeting of HER2-positive tumor using 2-helix affibody molecules, Amino acids 43(1) (2012) 405-413. [43] S. Qi, Z. Miao, H. Liu, Y. Xu, Y. Feng, Z. Cheng, Evaluation of four affibody-based near-infrared fluorescent probes for optical imaging of epidermal growth factor receptor positive tumors, Bioconjugate chemistry 23(6) (2012) 1149-1156. [44] N. Parashurama, T.D. O’Sullivan, A. De La Zerda, P. El Kalassi, S. Cho, H. Liu, R. Teed, H. Levy, J. Rosenberg, Z. Cheng, Continuous sensing of tumor-targeted molecular probes with a vertical cavity surface emitting laser-based biosensor, Journal of biomedical optics 17(11) (2012) 117004-117004. [45] Z. Miao, G. Ren, H. Liu, S. Qi, S. Wu, Z. Cheng, PET of EGFR expression with an 18F-labeled affibody molecule, Journal of Nuclear Medicine 53(7) (2012) 1110-1118. [46] H. Liu, C.M. Carpenter, H. Jiang, G. Pratx, C. Sun, M.P. Buchin, S.S. Gambhir, L. Xing, Z. Cheng, Intraoperative imaging of tumors using Cerenkov luminescence endoscopy: a feasibility experimental study, J Nucl Med 53(10) (2012) 1579-84. [47] J. Li, K. Chen, H. Liu, K. Cheng, M. Yang, J. Zhang, J.D. Cheng, Y. Zhang, Z. Cheng, Activatable near-infrared fluorescent probe for in vivo imaging of fibroblast activation protein-alpha, Bioconjugate chemistry 23(8) (2012) 1704-1711. [48] S.R. Kothapalli, H. Liu, J.C. Liao, Z. Cheng, S.S. Gambhir, Endoscopic imaging of Cerenkov luminescence, Biomed Opt Express 3(6) (2012) 1215-25. [49] L. Jiang, Z. Miao, R.H. Kimura, A.P. Silverman, G. Ren, H. Liu, H. Lu, J.R. Cochran, Z. Cheng, 1 1 1 I n-Labeled Cystine-Knot Peptides Based on the Agouti-Related Protein for Targeting Tumor Angiogenesis, BioMed Research International 2012 (2012). [50] H. Jiang, B.B. Kasten, H. Liu, S. Qi, Y. Liu, M. Tian, C.L. Barnes, H. Zhang, Z. Cheng, P.D. Benny, Novel, Cysteine-Modified Chelation Strategy for the Incorporation of [MI (CO) 3]+(M= Re, 99mTc) in an α-MSH Peptide, Bioconjugate chemistry 23(11) (2012) 2300-2312. [51] S. Hoppmann, S. Qi, Z. Miao, H. Liu, H. Jiang, C.S. Cutler, A. Bao, Z. Cheng, 177Lu–DO3A–HSA–ZEGFR: 1907: characterization as a potential radiopharmaceutical for radionuclide therapy of EGFR-expressing head and neck carcinomas, JBIC Journal of Biological Inorganic Chemistry 17(5) (2012) 709-718. [52] C.M. Carpenter, C. Sun, G. Pratx, H. Liu, Z. Cheng, L. Xing, Radioluminescent nanophosphors enable multiplexed small-animal imaging, Optics express 20(11) (2012) 11598-11604. [53] X. Zhang, H. Liu, Z. Miao, R. Kimura, F. Fan, Z. Cheng, Macrocyclic chelator assembled RGD multimers for tumor targeting, Bioorganic & medicinal chemistry letters 21(11) (2011) 3423-3426. [54] Y. Xu, H. Liu, Z. Cheng, Harnessing the power of radionuclides for optical imaging: Cerenkov luminescence imaging, Journal of Nuclear Medicine 52(12) (2011) 2009-2018. [55] C. Sun, G. Pratx, C.M. Carpenter, H. Liu, Z. Cheng, S.S. Gambhir, L. Xing, Synthesis and Radioluminescence of PEGylated Eu3+‐doped Nanophosphors as Bioimaging Probes, Advanced Materials 23(24) (2011). [56] G. Ren, G. Blum, M. Verdoes, H. Liu, S. Syed, L.E. Edgington, O. Gheysens, Z. Miao, H. Jiang, S.S. Gambhir, Non-invasive imaging of cysteine cathepsin activity in solid tumors using a 64 Cu-labeled activity-based probe, PLoS One 6(11) (2011) e28029. [57] S. Liu, H. Liu, G. Ren, R.H. Kimura, J.R. Cochran, Z. Cheng, PET Imaging of Integrin Positive Tumors Using F Labeled Knottin Peptides, Theranostics 1 (2011) 403-12. [58] S. Liu, H. Liu, H. Jiang, Y. Xu, H. Zhang, Z. Cheng, One-step radiosynthesis of (1)(8)F-AlF-NOTA-RGD(2) for tumor angiogenesis PET imaging, Eur J Nucl Med Mol Imaging 38(9) (2011) 1732-41. [59] L. Jiang, Z. Miao, R.H. Kimura, H. Liu, J.R. Cochran, C.S. Culter, A. Bao, P. Li, Z. Cheng, Preliminary evaluation of 177Lu-labeled knottin peptides for integrin receptor-targeted radionuclide therapy, European journal of nuclear medicine and molecular imaging 38(4) (2011) 613-622. [60] S. Hoppmann, Z. Miao, S. Liu, H. Liu, G. Ren, A. Bao, Z. Cheng, Radiolabeled Affibody− Albumin Bioconjugates for HER2-Positive Cancer Targeting, Bioconjugate chemistry 22(3) (2011) 413-421. [61] G. Ren, S. Liu, H. Liu, Z. Miao, Z. Cheng, Radiofluorinated rhenium cyclized α-MSH analogues for PET imaging of melanocortin receptor 1, Bioconjugate chemistry 21(12) (2010) 2355-2360. [62] Z. Miao, G. Ren, H. Liu, L. Jiang, Z. Cheng, Cy5. 5-labeled Affibody molecule for near-infrared fluorescent optical imaging of epidermal growth factor receptor positive tumors, Journal of biomedical optics 15(3) (2010) 036007-036007-7. [63] Z. Miao, G. Ren, H. Liu, L. Jiang, Z. Cheng, Small-animal PET imaging of human epidermal growth factor receptor positive tumor with a 64Cu labeled affibody protein, Bioconjugate chemistry 21(5) (2010) 947-954. [64] H. Liu, X. Zhang, B. Xing, P. Han, S.S. Gambhir, Z. Cheng, Radiation-luminescence-excited quantum dots for in vivo multiplexed optical imaging, Small 6(10) (2010) 1087-91. [65] H. Liu, G. Ren, Z. Miao, X. Zhang, X. Tang, P. Han, S.S. Gambhir, Z. Cheng, Molecular optical imaging with radioactive probes, PLoS One 5(3) (2010) e9470. [66] H. Liu, G. Ren, S. Liu, X. Zhang, L. Chen, P. Han, Z. Cheng, Optical imaging of reporter gene expression using a positron-emission-tomography probe, J Biomed Opt 15(6) (2010) 060505. [67] L. Jiang, R.H. Kimura, Z. Miao, A.P. Silverman, G. Ren, H. Liu, P. Li, S.S. Gambhir, J.R. Cochran, Z. Cheng, Evaluation of a 64Cu-labeled cystine-knot peptide based on agouti-related protein for PET of tumors expressing αvβ3 integrin, Journal of Nuclear Medicine 51(2) (2010) 251-258. [68] Z. Cheng, O.P. De Jesus, D.J. Kramer, A. De, J.M. Webster, O. Gheysens, J. Levi, M. Namavari, S. Wang, J.M. Park, 64Cu-labeled affibody molecules for imaging of HER2 expressing tumors, Molecular Imaging and Biology 12(3) (2010) 316-324. [69] G. Ren, Z. Miao, H. Liu, L. Jiang, N. Limpa-Amara, A. Mahmood, S.S. Gambhir, Z. Cheng, Melanin-targeted preclinical PET imaging of melanoma metastasis, Journal of Nuclear Medicine 50(10) (2009) 1692-1699. [70] G. Ren, Z. Liu, Z. Miao, H. Liu, M. Subbarayan, F.T. Chin, L. Zhang, S.S. Gambhir, Z. Cheng, PET of malignant melanoma using 18F-labeled metallopeptides, Journal of Nuclear Medicine 50(11) (2009) 1865-1872. [71] Z. Miao, G. Ren, H. Liu, R.H. Kimura, L. Jiang, J.R. Cochran, S.S. Gambhir, Z. Cheng, An engineered knottin peptide labeled with 18F for PET imaging of integrin expression, Bioconjugate chemistry 20(12) (2009) 2342-2347.