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个人简介

侯悦,女,博士,现任东北大学生命科学与健康学院副院长,教授,博士生导师,中国药理学会理事,国家自然科学基金委会审专家,中国博士后科学基金评审专家,教育部博士学位论文评审专家。2000年毕业于沈阳药科大学日语药学专业获学士学位,作为推免生进行硕博连读,2005年于同校获得药理学博士学位。致力于中药与民族药防治脑卒中、阿尔茨海默症等中枢神经系统重大疾病的药效物质基础及活性成分筛选、药效评价与作用机制研究。作为负责人主持国家自然基金面上项目、国家自然科学基金联合基金项目、国家自然科学基金青年基金项目、中国博士后科学基金、辽宁省高等学校优秀人才支持计划、教育部高等学校博士学科点专项科研基金、辽宁省教育厅科学技术研究项目等多项课题;作为副组长参加国家科技重大专项课题3项。获辽宁省优秀博士学位论文,辽宁省自然科学学术成果二等奖2项。目前,在国际学术期刊上发表SCI收载文章近80篇,近五年作为第一作者或通讯作者文章发表JCR一区文章20篇,其中Top期刊17篇。授权发明专利6项。作为主编出版研究生教材1部。指导博士硕士研究生46人,近五年,1人次论文获评东北大学优秀硕士学位论文,为学院首例;2人次获得“国家奖学金”;1人次获批教育部基本科研业务费优秀学生科研创新项目且结题获评优秀;1人次获得“辽宁省优秀毕业生”称号;2人次获得“东北大学优秀毕业研究生”称号;1人次获得“东北大学优秀研究生干部”称号;4人次获得“东北大学优秀研究生”称号;2人次获得生命科学与健康学院“优秀共产党员”称号。

研究领域

神经药理学及中药药理学

近期论文

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Xu J, Liu J, Li Q, Mi Y, Zhou D, Meng Q, Chen G, Li N, Hou Y. Pterostilbene Alleviates Aβ1-42 -Induced Cognitive Dysfunction via Inhibition of Oxidative Stress by Activating Nrf2 Signaling Pathway. Mol Nutr Food Res. 2021 Jan;65(2):e2000711.(JCR一区,Top期刊) Bai Z, Liu J, Mi Y, Zhou D, Chen G, Liang D, Li N, Hou Y. Acutissimalignan B from traditional herbal medicine Daphne kiusiana var. atrocaulis (Rehd.) F. Maekawa inhibits neuroinflammation via NF-κB Signaling pathway. Phytomedicine. 2021 Apr;84:153508.(JCR一区,Top期刊) Mi Y, Jiao K, Xu JK, Wei K, Liu J, Meng Q, Guo T, Zhang X, Zhou D, Qing D, Sun Y, Li N, Hou Y. Kellerin from Ferulasinkiangensis exerts neuroprotective effects after focal cerebral ischemia in rats by inhibiting microglia-mediated inflammatory responses. J Ethnopharmacol. 2021 Apr 25;269:113718.(JCR一区,Top期刊) Wang Y, Zhou D, Meng Q, Xu L, Yao X, Ni X, Xie H, Wu G, Chen G, Hou Y, Li N. Anti-neuroinflammatory effects in vitro and in vivo, and chemical profile of Jatropha curcas L. Bioorg Chem. 2022 Mar 14;122:105720. (JCR一区,Top期刊) Zhou D, Zhang T, Liu Q, Liu J, Yang Y, Lin B, Chen G, Hou Y, Li N. Structural elucidation of spiro cyclohexandienonylnaphthalenes with potential anti-neuroinflammatory activities from Caragana acanthophyllaKom. Phytochemistry. 2021 Dec 19;192:112976.(JCR一区) Xiao J, Wang Y, Yang Y, Liu J, Chen G, Lin B, Hou Y, Li N. Natural potential neuroinflammatory inhibitors from Stephania epigaea H.S. Lo. Bioorg Chem. 2021 Feb; 107:104597.(JCR一区,Top期刊) Chen G, Xie Y, Yang Y, Zhou D, Hao Y, Liu Y, Cheng M, Hou Y, Li N. Natural therapeutic agents for neurodegenerative diseases from the shells of Xanthocerassorbifolium. Bioorg Chem. 2020 Aug; 101:104038.(JCR一区,Top期刊) Guo T, Zhou D, Yang Y, Zhang X, Chen G, Lin B, Sun Y, Ni H, Liu J, Hou Y, Li N. Bioactive sesquiterpene coumarins from the resin of Ferulasinkiangensis targeted on over-activation of microglia. Bioorg Chem. 2020 Nov;104:104338.(JCR一区,Top期刊) Hao T, Yang Y, Li N, Mi Y, Zhang G, Song J, Liang Y, Xiao J, Zhou D, He D, Hou Y. Inflammatory mechanism of cerebral ischemia-reperfusion injury with treatment of stepharine in rats. Phytomedicine. 2020 Dec;79:153353.(JCR一区,Top期刊) Liu J, Xu J, Mi Y, Yang Y, Li Q, Zhou D, Wei K, Chen G, Li N, Hou Y. Pterostilbene alleviates cerebral ischemia and reperfusion injury in rats by modulating microglial activation.Food Funct. 2020 Jun 24;11(6):5432-5445.(JCR一区,Top期刊) Zhang W, Mi Y, Jiao K, Xu J, Guo T, Zhou D, Zhang X, Ni H, Sun Y, Wei K, Li N, Hou Y. Kellerin alleviates cognitive impairment in mice after ischemic stroke by multiple mechanisms. Phytother Res. 2020 Sep;34(9):2258-2274. doi: 10.1002/ptr.6676.(JCR一区) Zhou D, Chang W, Liu B, Chen G, Yang Y, Hao Y, Hou Y, Li N. Stilbenes from the tubers of Bletilla striata with potential anti-neuroinflammatory activity. Bioorg Chem. 2020 Apr;97:103715.(JCR一区,Top期刊) Liu X, Jiao K, Jia CC, Li GX, Yuan Q, Xu JK, Hou Y, Wang B. BAP31 regulates IRAK1-dependent neuroinflammation in microglia. J Neuroinflammation. 2019 Dec 28;16(1):281.(JCR一区,Top期刊) Zhou D, Li Y, Chen G, Yang Y, Mi Y, Lin B, Li W, Hou Y, Li N. Structural elucidation and anti-neuroinflammatory activities of lignans from the testas of Verniciamontana. Bioorg Chem. 2020 Apr;97:103690.(JCR一区,Top期刊) Chen G, Zhao W, Li Y, Zhou D, Ding J, Lin B, Li W, Yang Y, Liu J,Hou Y, Li N. Bioactive chemical constituents from the seed testa of Verniciafordii as potential neuroinflammatory inhibitors. Phytochemistry. 2020 Mar;171:112233.(JCR一区) Zhou D, Chen G, Ma Y, Wang C, Lin B, Yang Y, Li W, Koike K, Hou Y, Li N. Isolation, Structural Elucidation, Optical Resolution, and Antineuroinflammatory Activity of Phenanthrene and 9,10-Dihydrophenanthrene Derivatives from Bletilla striata.J Nat Prod. 2019 Aug 23;82(8):2238-2245.(JCR一区,Top期刊) Xiao J, Hao T, Chen G, Song J, Lin B, Li W, Xu J, Liu J, Hou Y, Li N. Natural neuroprotective alkaloids fromStephania japonica (Thunb.) Miers. Bioorg Chem. 2019 Oct;91:103175.(JCR一区,Top期刊) Hou Y, Zhang Y, Mi Y, Wang J, Zhang H, Xu J, Yang Y, Liu J, Ding L, Yang J, Chen G, Wu C. A Novel Quinolyl-Substituted Analogue of Resveratrol Inhibits LPS-Induced Inflammatory Responses in Microglial Cells by Blocking the NF-κB/MAPK Signaling Pathways. Mol Nutr Food Res. 2019 Oct;63(20):e1801380.(JCR一区,Top期刊) Zhang GJ, Pan QM, Zhang YL, Liao HB, Yang YQ, Hou Y, Liang D. Coumarinolignoids and Taraxerane Triterpenoids from Sapium discolor and Their Inhibitory Potential on Microglial Nitric Oxide Production.J Nat Prod. 2018 Oct 26;81(10):2251-2258.(JCR一区,Top期刊) Chen R, Yang Y, Xu J, Pan Y, Zhang W, Xing Y, Ni H, Sun Y, Hou Y, Li N. Tamarixhohenackeri Bunge exerts anti-neuroinflammatory effects on lipopolysaccharide-activated microglia in vitro.Phytomedicine. 2018 Feb 1;40:10-19.(JCR一区,Top期刊)

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