McHenry, Charles - University of Colorado Boulder - Department of Chemistry & Biochemistry

个人简介

Education: 1966-1970 B.S. in Chemistry, Purdue University 1970-1974 Ph.D., Department of Chemistry, University of California, Santa Barbara, and Department of Biochemistry and Biophysics, University of California Medical School, San Francisco. Advisor: Daniel Santi, M.D., Ph.D. 1974-1976 Postdoctoral Fellow of the Cystic Fibrosis Foundation Stanford University Medical School Department of Biochemistry, Stanford, California. Advisor: Arthur Kornberg, M.D.

研究领域

Chemical Biology/Genetics Molecular Biophysics Nucleic Acids Proteins & Enzymology

近期论文

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Yuan, Q. and McHenry, C. (2014) Cycling of the E. coli lagging strand polymerase is triggered exclusively by the availability of a new primer at the replication fork. Nucleic Acids Res. 42, 1747-1756. Antony, E., Weiland, E., Yuan, Q., Manhart, C.M., Nguyen, B., Kozlov, A.G., McHenry, C. and Lohmman, T.M. (2013) Multiple C-Terminal Tails within a Single E. coli SSB Homotetramer Coordinate DNA Replication and Repair. J. Mol. Biol. 425, 4802-4819. Ungermannova D., Lee J., Zhang G., Dallmann H.G., McHenry C. and Liu X. (2013) High-Throughput Screening AlphaScreen Assay for Identification of Small-Molecule Inhibitors of Ubiquitin E3 Ligase SCFSkp2-Cks1. J. Biomol Screen., 8, 910-20. Seco, E., Zinder, J., Manhart, C.M., Piano, A.L., McHenry, C. and Ayora, S. (2013) Bacteriophage SPP1 in vitro DNA Replication Strategies Promote Viral and Disable Host Replication. Nucleic Acid Res., 41, 1711-1721. Manhart, C.M. and McHenry, C. (2013) The PriA Replication Restart Protein Blocks Replicase Access Prior to Helicase Assembly and Directs Template Specificity through its ATPase Activity. J. Biol. Chem., 288, 3989-3999. McHenry, C. Replicative DNA Polymerases. E. Bell, J. Bond, J. Klinman, B. Siler Masters, and R. Wells (Eds.),Molecular Life Sciences: An Encyclopedic Reference. New York: Springer. In press. Dohrmann, P.R., Manhart, C.M., Downey, C.D. and McHenry, C. (2011) The Rate of Polymerase Release upon Filling the Gap between Okazaki Fragments is Inadequate to Support Cycling During Lagging Strand Synthesis. J. Mol. Biol., 414,15-27. McHenry, C. (2011) Bacterial Replicases and Related Polymerases. Curr.Opin.Chem. Biol., 15, 587-594. Downey, C.D., Crooke, E. and McHenry, C. (2011) Polymerase Chaperoning and Multiple ATPase Sites Enable the E. coli DNA Polymerase III Holoenzyme to Rapidly Form Initiation Complexes. J. Mol. Biol., 412, 340-353. McHenry, C. (2011) Breaking the Rules: Bacteria That Use Several DNA Polymerase IIIs. EMBO Rep. 12, 408-414. McHenry, C. (2011) DNA Replicases from a Bacterial Perspective. Annu. Rev. Biochem., 80, 403-436. Wieczorek, .A, Downey, C.D., Dallmann, H.G. and McHenry, C. (2010) Only one ATP-binding DnaX Subunit is Required for Initiation Complex Formation by the Escherichia coli DNA Polymerase III Holoenzyme. J. Biol. Chem., 285, 29049-29053. Dallmann, H.G.,Fackelmayer, O.J., Tomer, G., Chen, J.Y., Wiktor-Becker, A., Ferrara, T., Pope, C., Oliveira, M.T., Burgers, P.M.J., Kaguni, L.K. and McHenry, C. (2010) Parallel Multiplicative Target Screening Against Divergent Bacterial Replicases: Identification of Specific Inhibitors with Broad Spectrum Potential. Biochemistry, 49, 2551-2562. Downey, C.D. and McHenry, C. (2010) Chaperoning of a Replicative Polymerase onto a Newly-Assembled DNA Bound Sliding Clamp by the Clamp Loader. Mol. Cell, 37,481-491. Sanders, G.M., Dallmann, H.G. and McHenry, C. (2010) Reconstitution of the B. subtilis Replisome with 13 Proteins including Two Distinct Replicases. Mol. Cell, 37, 273-281. Yuan,Q. and McHenry, C. (2009) Strand Displacement by DNA Polymerase III Occurs through a tau-psi-chi Link to SSB Coating the Lagging Strand Template. J. Biol. Chem., 284, 31672-31679. Guiles, J., Sun, X., Critchley, I.A., Ochsner, U., Tregay, M., Stone, K., Bertino, J., Green, L., Sabin, R., Dean, F., Dallmann, H.G., McHenry, C. and Janic, N. (2009) Quinazolin-2-ylamino-quinazolin-4-ols as Novel Non-nucleoside Inhibitors of Bacterial DNA Polymerase III. Bioorg Med Chem Lett., 19, 800-802. Stano, N., Chen, J. and McHenry, C. (2006) A Coproofreading Zn+2-dependent Exonuclease within a Bacterial Replicase. Nat. Struct. Mol. Biol.,13, 458-459. Wieczorek, A. and McHenry, C. (2006) The N-terminal php Domain of the alpha Subunit of the E. coli Replicase Binds the epsilon Proofreading Subunit. J. Biol. Chem., 281, 12561-12567. Jarvis, T.C., Beaudry, A.A., Bullard, J.M., Ochsner, U., Dallmann, H.G. and McHenry, C., (2005) Discovery and Characterization of the Cryptic gamma Subunit of the Pseudomonad DNA Replicase. J. Biol. Chem., 280, 40465-40473.