Ghildyal, Reena - University of Canberra - Faculty of Education, Science, Technology and Mathematics, Science

个人简介

Reena Ghildyal obtained her PhD in Life Science from Jawaharlal Nehru University, New Delhi, India; a premier Indian research university. This was followed by postdoctoral fellowships at the State Department of Agriculture, and Macfarlane Burnet Institute in Melbourne, Australia. In 2004 Reena was invited to establish a respiratory virology research group as part of a new Chinese Government initiative within Fudan University, Shanghai. On her return to Australia in 2007, she has continued her association with Fudan University and has been instrumental in establishing several bilateral research collaborations between Chinese and Australian scientists. Reena moved to University of Canberra in 2010 where she is currently Associate Professor in Microbiology and Director, Centre for Research in Therapeutic Solutions. The focus of Reena's research is molecular pathogenesis of respiratory viruses with special reference to asthma exacerbations. Current projects include the validation of respiratory syncytial virus (RSV) vaccine candidates in vitro and in vivo; elucidating the role of cytoskeleton in RSV assembly, investigating the role of rhinovirus (HRV) proteases in disease. Reena collaborates with research groups within Australia (Monash University, University of Queensland) and Internationally (University of South Florida, University of Georgia, Imperial College, Fudan University) and her research is funded by National Health and Medical Research Council, Australia-China Science Research Fund and Australia-India Science and Technology Research Fund.

研究领域

Molecular pathogenesis of respiratory viruses Molecular basis of asthma Respiratory virus assembly

近期论文

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Ghildyal, R, Hartley, C., Varrasso, A., Meanger, J., Voelker, D. R., Anders, M. and Mills, J. 1999. Surfactant protein A (SP-A) neutralizes respiratory syncytial virus (RSV) by binding to the fusion (F) glycoprotein. Journal of Infectious Diseases. 180:2009. Ghildyal, R, Mills, J, Meanger, J. 2003. The matrix (M) protein of Respiratory syncytial virus localises to the nucleus and inhibits host cell transcription. Archives of Virology. 148:1419. Marty, A, Meanger, J, Mills, J, Shields B and R. Ghildyal. 2004. Association of matrix protein of respiratory syncytial virus with the host cell membrane of infected cells. Archives of Virology. 149:199. Ghildyal R, Dagher H, Donninger H, de Silva D, Li X, Freezer NJ, Wilson JW, Bardin PG. 2005. Rhinovirus infects primary human airway fibroblasts and induces a neutrophil chemokine and a permeability factor. Journal of Medical Virology 75:608. Ghildyal R, Li D, Peroulis I, Shields B, Bardin PG, Teng MN, Collins P, Meanger J and Mills J. 2005. Interaction between the respiratory syncytial virus G glycoprotein cytoplasmic domain and the matrix protein. Journal of General Virology; 86: 1879. Ghildyal R, Ho A, Wagstaff KM, Dias MM, Barton CL, Jans P, Bardin PG and Jans DA. 2005. Nuclear import of the respiratory syncytial virus matrix protein is mediated by importin 1 independent of importin . Biochemistry. 44:12887. Ghildyal R, Ho A and Jans D. 2006. Central role of the respiratory syncytial virus matrix protein in infection. FEMS Microbiology Reviews. 30:692. Yu X, Wang S, Guan J, Mahemuti, Purhati, Gou A, Liu Q, Jin X, Ghildyal R. 2007. Analysis of the cause of increased measles incidence in Xinjiang, China in 2004. Pediatric Infectious Diseases Journal. 26:513. Yu X, Cheng Y, Shi B, Qian F, Wang F, Liu X, Yang H, Xu Q, Qi T, Zha L, Yuan Z, Ghildyal R. 2008. Measles virus infection in adults induces production of IL-10 and is associated with increased CD4+CD25+ regulatory T cells. Journal of Immunology, 181:7356. Li D, Jans DA, Bardin PG, Meanger J, Mills J, Ghildyal R. 2008. Association of respiratory syncytial virus M protein with viral nucleocapsids is mediated by the M2-1 protein. Journal of Virology. 82:8863. Thomas BJ, Lindsay M, Dagher H, Freezer NJ, Li D, Ghildyal R, Bardin PG. 2009. Transforming growth factor-β enhances rhinovirus infection by diminishing early innate responses. American Journal of Respiratory Cell and Molecular Biology, 41:339. Ghildyal, R, Ho, A, Dias, M, Soegiyono, L, Bardin, PG, Tran, KC, Teng, MN, Jans, DA. 2009. The Respiratory Syncytial Virus Matrix Protein Possesses 1 a Crm1-Mediated Nuclear Export Mechanism. Journal of Virology, 83:5353. Ghildyal, R, Jordan, B, Li D, Dagher H, Bardin, PG, Gern JE, Jans, DA. 2009. Rhinovirus 3C Protease can Localise in the Nucleus and Alter Active and Passive Nucleocytoplasmic Transport. Journal of Virology, 83:7349. Walker EJ, Younessi P, Fulcher AJ, McCuaig R, Thomas BJ, Bardin PG, Jans DA, Ghildyal R. 2013. Rhinovirus 3C protease facilitates specific nucleoporin cleavage and mislocalisation of nuclear proteins in infected host cells. PLoS One. 8(8):e71316. Bajorek M, Caly L, Tran KC, Maertens GN, Tripp RA, Bacharach E, Teng MN, Ghildyal R, Jans DA. 2014 The Thr205 Phosphorylation Site Within Respiratory Syncytial Virus Matrix (M) Protein Modulates M Oligomerization and Virus Production. Journal of Virology. Mar 26. [Epub ahead of print]