Beard, Nicole - University of Canberra - Faculty of Education, Science, Technology and Mathematics, Science

个人简介

Dr Beard and her research team investigate how intracellular calcium signaling pathways initiate muscle contraction. We explore and define the mechanisms which lead to control of calcium signalling and the way in which these are disrupted in skeletal myopathies, cardiomyopathy and heart failure.

研究领域

Heart failure Cardiomyopathy Skeletal muscle ageing and myopathy

近期论文

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Hanna AD, Lam, A, Tham, S, Dulhunty, AF and Beard, NA. (2014) Adverse Effects of Doxorubicin and its Metabolic Product on Cardiac RyR2 and SERCA2A. Mol Pharmacol Hanna AD, Lam, A, Thekkedam, C, Gallant, EM, Beard, NA and Dulhunty, AF. (accepted 27/07/14) Cardiac ryanodine receptor activation by high Ca2+ store load is reversed in a reducing cytoplasmic redox environment. J Cell Sci Walweel K, Li, L, Molenaar, P, Imtiaz, MS, dos Remedios, CG, Beard, NA, Dulhunty, AF, van Helden, DF and Laver, DR. (accepted 28/06/14) Regulation of human RyR2 by Ca2+ and Mg2+ in the cytoplasm and in the lumen of the sarcoplasmic reticulum. J Gen Physiol Rebbeck RT, Karunasekara, Y, Board, PG, Beard, NA, Casarotto, MG and Dulhunty, AF. (2014) Skeletal muscle excitation-contraction coupling: who are the dancing partners? Int J Biochem Cell Biol 48: 28-38. Li J, Imtiaz, MS, Beard, NA, Dulhunty, AF, Thorn, R, van Helden, DF and Laver, DR. (2013) b-Adrenergic stimulation increases RyR2 activity via intracellular Ca2+ and Mg2+ regulation. PLoS One 8: e58334 Smith JJ, Vetter, I, Lewis, RJ, Peigneur, S, Tytgat, J, Lam, A, Gallant, EM, Beard, NA, Alewood, PF and Dulhunty, AF. (2013) Multiple actions of phi-LITX-Lw1a on ryanodine receptors reveal a functional link between scorpion DDH and ICK toxins. Proc Natl Acad Sci U S A 110: 8906-8911 Wium E, Dulhunty, AF and Beard, NA. (2012) A skeletal muscle ryanodine receptor interaction domain in triadin. PLoS One 7: e43817 Dulhunty AF, Wium, E, Li, L, Hanna, AD, Mirza, S, Talukder, S, Ghazali, NA and Beard, NA. (2012) Proteins within the intracellular calcium store determine cardiac RyR channel activity and cardiac output. Clin Exp Pharmacol Physiol. 39: 477-484 Dulhunty AF, Beard, NA and Hanna, AD. (2012) Regulation and dysregulation of cardiac ryanodine receptor (RyR2) open probability during diastole in health and disease. J Gen Physiol 140: 87-92 Hanna AD, Janczura, M, Cho, E, Dulhunty, AF and Beard, NA. (2011) Multiple actions of the anthracycline daunorubicin on cardiac ryanodine receptors. Mol Pharmacol 80: 538-549 Dulhunty AF, Casarotto, MG and Beard, NA. (2011 ) The ryanodine receptor: a pivotal Ca2+ regulatory protein and potential therapeutic drug target. Curr Drug Targ 12: 709-723 Murphy RM, Mollica, JP, Beard, NA, Knollman, BC and Lamb, GD. (2011) Quantification of calsequestrin 2 (CSQ2) in sheep cardiac muscle and Ca2+-binding protein changes in CSQ2-knockout mice. Am J Physiol Heart Circ Physio 300: Rebbeck RT, Karunasekara, Y, Gallant, EM, Board, PG, Beard, NA, Casarotto, MG and Dulhunty, AF. (2011) The beta(1a) subunit of the skeletal DHPR binds to skeletal RyR1 and activates the channel via its 35-residue C-terminal tail. Biophys J 100: 922-930 Beard NA, Wei, L and Dulhunty, AF. (2009) Ca2+ signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin. Eur Biophys J 39: 27-36 Beard NA, Wei, L and Dulhunty, AF. (2009) Control of muscle ryanodine receptor calcium release channels by proteins in the sarcoplasmic reticulum lumen. Clin Exp Pharmacol Physiol 36: 340-345 Dulhunty A, Wei, L and Beard, N. (2009) Junctin - the quiet achiever. J Physiol 587: 3135-3137 Wei L, Gallant, EM, Dulhunty, AF and Beard, NA. (2009) Junctin and triadin each activate skeletal ryanodine receptors but junctin alone mediates functional interactions with calsequestrin. Int J Biochem Cell Biol 41: 2214-2224 Wei L, Hanna, AD, Beard, NA and Dulhunty, AF. (2009) Unique isoform-specific properties of calsequestrin in the heart and skeletal muscle. Cell Calc 45: 474-484 Murphy RM, Larkins, NT, Mollica, JP, Beard, NA and Lamb, GD. (2009) Calsequestrin content and SERCA determine normal and maximal Ca2+ storage levels in sarcoplasmic reticulum of fast- and slow-twitch fibres of rat. J Physiol 587: 443-460