个人简介

Alison obtained her BBiotech(Hons) from Flinders University during which time she discovered the field of drug metabolism. She continued to a PhD in genetic toxicology and further developed her interests in pharmacogenetics as a postdoctoral fellow, firstly at the Mayo Clinic and then at the John Curtin School of Medical Research at ANU. She joined UC in 2008 and continues to have broad research and teaching interests in the areas of pharmacology and toxicology. Since completing a Graduate Certificate in Higher Education she has also become interested in teaching methodologies to better integrate the basic sciences into clinical education.

研究领域

Pharmacology Toxicology Pharmaceutical Sciences

Pharmacogenetics Phase II drug metabolism Roles of metabolic enzymes in mitochondrial function Medicines and lactation Variation in efficacy of pain medications

近期论文

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Blackburn AC, Coggan M, Shield AJ, Cappello J, Theodoratos A, Murray TP, Rooke M, Larter CZ, Koina ME, Dahlstrom JE, Matthaei KI, Board PG. (2011) Glutathione transferase kappa deficiency causes glomerular nephropathy without overt oxidative stress. Laboratory Investigation 91: 1572–1583 Shield AJ, Murray TP, Cappello JY, Coggan M, Board PG. (Polymorphisms in the human glutathione transferase Kappa (GSTK1) promoter alter gene expression. Genomics Shield AJ, Murray TP, and Board PG (2006) Functional characterisation of ganglioside-induced differentiation-associated protein 1 as a glutathione transferase. Biochem Biophys Res Commun. 347(4):859-66. Shield AJ and McCormack C (2010) Learning to negotiate roles and responsibilities within the private spaces of a doctoral supervisory relationship. Proc 2010 Quality in Postgraduate Research Conference. The Centre for Educational Development and Academic Methods, The Australian National University. Pg 299 Shield AJ, Blackburn AC, Coggan M, Cappello JY, Rooke MW, Piele ML, Murray TM and Board PG (2009) Potential mechanisms for increase paracetamol sensitivity in a GST Kappa knockout mouse. Proc ASCEPT 14: 1(70). Coggan M, Matthaei KI, Blackburn AC, Cappello JY, Shield AJ, Board PG and Dahlstrom JE (2006) The generation and characterization of glutathione transferase Kappa deficient mice. Drug Met Rev 38(3): 124.