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毕业于兰州大学化学化工学院功能有机分子国家重点实验室,1997年获学士学位,2002年获博士学位,导师贾忠建教授。2003-2006年在加拿大British Columbia大学化学系John R. Scheffer教授课题组从事有机光化学方向的研究工作。2006年作为哈尔滨工业大学海外引进人才回国,受聘于基础与交叉科学研究院,担任教授,博士生导师。入选2006年教育部“新世纪优秀人才支持计划”。2017年加入哈尔滨工业大学(深圳)理学院。专注于有机合成的绿色化研究与药物合成应用。先后承担并完成了国家自然科学基金、教育部新世纪优秀人才计划、黑龙江省自然科学基金、广东省自然科学基金、国家重点实验室自主课题、哈工大基础研究杰出人才“跃升”计划、哈工大科技创新团队基金等项目。在相关研究领域发表科研论文百余篇,申请发明专利二十余项。 教育经历 1993年-1997年 兰州大学 化学化工学院,化学基础理论班(国家基础科学人才培养基地),获理学学士学位 1997年-2002年 兰州大学 化学化工学院,功能有机分子国家重点实验室,有机化学专业,获理学博士学位 研究与工作经历 2003年-2006年 The University of British Columbia ,化学化工学院,博士后 2006年-2017年 哈尔滨工业大学,基础与交叉科学研究院,教授,博导 2017年 哈尔滨工业大学(深圳),教授,博导 科研项目 2023-2025 基于自由基重排策略实现的 MCRs 光化反应研究 2022-2024 Norrish-Yang光环化与电化学方法相结合的合成反应研究 2019-2021 基于1,2-双自由基的氮杂环类活性化合物的光化学合成研究 2019-2021 手性模板法在pterocarpan类药物分子合成中的应用研究 2020-2022 手性药物合成中的不对称光环化反应研究 2017-2019 光环化反应在手性药物全合成中的应用研究 2014-2018 紫外光激发的单电子转移光化反应研究 2011-2013 利用Norrish II型光化关环反应与断裂反应进行吡咯里西啶生物碱与前列腺素等天然产物的不对称合成 2010-2012 天然药源中的手性先导化合物研究 2009-2011 利用环境友好的绿色光化学方法进行手性药物合成 2008-2010 环体系的不对称光化学研究 2007-2009 东北寒区药用植物生物活性成分及其药理作用研究

研究领域

有机合成的绿色化研究与药物合成应用

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Visible-light-induced dehydrogenative amidation of aldehydes enabled by iron salts. Chem. Commun. 2023, 59, 2771. Photoinduced Synthesis of Functionalized Oxacyclic Spirooxindoles via Ring Expansion. Org. Lett. 2023, 25, 506. Electrochemical synthesis of oxazoles via a phosphine-mediated deoxygenative [3+2] cycloaddition of carboxylic acids. Green Chem. 2023, 25, 1435. Electrochemical Synthesis of trans-Olefins from Buta-1,3-dienes and Alkyl Halides. Synthesis, 2023, doi: 10.1055/a-2006-1285. Organoboron Reagent-Controlled Selective (Deutero)Hydrodefluorination. Angew. Chem. Int. Ed. 2023, 62, e202217244. Four-Component Synthesis of Spiro-Imidazolidines Enabled by Carbon Nitride Photocatalysis. ACS Catal. 2023, 13, 866. Photo-induced decarboxylative hydroacylation of α-oxocarboxylic acids with terminal alkynes by radical addition-translocation-cyclization in water. Org. Chem. Front. 2022, 9, 6513. Synthesis of -Hydroxy and -Alkoxy Esters Enabled by a VisibleLight-Induced O-H Insertion Reaction of Diazo Compounds. SYNLETT. 2022, 33, 2048-2052. Nickel-Catalyzed Reductive Dicarbofunctionalization of Vinylarenes Enabled by Electrochemical Process. Org. Lett. 2022, 24, 7583-7588. Photoinduced Remote C(sp3)-H Cyanation and Oxidation Enabled by a Vinyl Radical-Mediated 1,5-HAT Strategy. Org. Lett. 2022, 24, 6560-6565. Iron-catalyzed ring-opening of cyclic carboxylic acids enabled by photoinduced ligand-to-metal charge transfer. Green Chem. 2022, 24, 5553. Highly Diastereoselective Synthesis of γ-Lactams Enabled by Photoinduced Deaminative [3 + 2] Annulation Reaction. Org. Lett. 2022, 24, 4365-4370. Electrochemical Synthesis of β-Functionalized Ketones via RingOpening of Cycloalkanols. Org. Lett. 2022, 24, 4421-4426. Transition Metal-Free Radical α-Oxy C H Cyclobutylation via Photoinduced Hydrogen Atom Transfer. Adv. Synth. Catal. 2022, 364, 2140-2145. Electrochemical Reduction of Aldehydes and Ketones for the Synthesis of Alcohols and Diols under Ambient Conditions. Synlett. 2022, 33, 1302-1308. Nickel-Catalyzed Reductive Acylation of Carboxylic Acids with Alkyl Halides and N-Hydroxyphthalimide Esters Enabled by Electrochemical Process. Adv. Synth. Catal. 2022, 364, 1526-1531. Cascade cyclization for the synthesis of indolo [2,1-α]isoquinoline derivatives via visible-lightinduced halogen-atom-transfer (XAT) and hydrogen-atom-transfer (HAT). Org. Biomol. Chem. 2022, 20, 1731. Transition Metal-Free Synthesis of Sulfonyl- and Bromo-Substituted Indolo[2,1-α]isoquinoline Derivatives through Electrochemical Radical Cascade Cyclization,Adv. Synth. Catal. 2021, 363, 1944-1954. Visible-Light-Induced Multicomponent Synthesis of γ-Amino Esters with Diazo Compounds, Org. Lett. 2021, 23, 6278-6282. Multicomponent Synthesis of α-Branched Tertiary and Secondary Amines by Photocatalytic Hydrogen Atom Transfer Strategy, Org. 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Direct C-H Multi?uoroarylation of Ethers through Hydrogen Atom Transfer Using Photoredox Catalysis, J. Org. Chem. 2019, 84, 6895-6903. Visible-Light Promoted Selective Imination of Unactivated C-H Bonds via Copper-nitrene Intermediates for the Synthesis of 2H?Azirines, Org. Lett. 2019, 21, 8323-8327. Nitroacenaphthene as a New Photocatalyst for the Synthesis of Sulfonyl Amidines, Synthesis, 2019, 51, 4425-4433. UV light-mediated decarboxylative cross-Coupling reaction of aryl acetic acidsJ. Photochem. Photobio. A: Chemistry 2018, 355, 298-304. Photoinduced Cross-Coupling of Amines with 1,2-Diiodobenzene and Its Application in the Synthesis of Carbazoles. Synthesis, 2018, 50, 2981-2989. Visible-Light-Mediated Ring-Opening Strategy for the Regiospecific Allylation/Formylation of Cycloalkanols. .J. Org. Chem. 2018, 83, 9696-9706. Visible-Light-Induced C(sp(2))-P Bond Formation by Denitrogenative Coupling of Benzotriazoles with Phosphites. Org. Lett. 2018, 20, 5370-5374. Photoinduced Regioselective Lactonization of ortho-Iodobenzoic Acids with Alkenes: Synthesis of 3,4-Dihydroisocoumarin Derivatives. Synlett 2018, 29, 131-135. Photoredox-Catalyzed Decarboxylative C-H Acylation of Heteroarenes. Synlett. 2018, 14, 1881-1886. Photoinduced Intermolecular [4+2] Cycloaddition Reaction for Construction of Benzobicyclo[2.2.2]octane Skeletons, J. Org. Chem., 2017, 82, 1389-1402. Selective C-H trifluoromethylation of benzimidazoles through photoredox catalysis, Chem. Commun., 2017, 53, 1041-1044. UV Light Induced Direct Synthesis of Phenanthrene Derivatives froma Linear 3-Aryl-N-(arylsulfonyl) Propiolamides, Org. Lett.2016, 18, 2280-2283. Visible-Light-Mediated 1,7-Enyne Bicyclizations for Synthesis ofCyclopenta[c]quinolines and Benzo[j]phenanthridines, Org. Lett.2016, 18, 600-603. Visible light-induced cyclization of electron-enriched phenyl benzyl sulfides: synthesis of tetrahydrofurans and tetrahydropyrans, Synlett. 2016, 27, 1391-1396. Visible light-induced difunctionalization of electron-enriched styrenes: synthesis of tetrahydrofurans and tetrahydropyrans, Chem. Commun. 2015, 51, 399-401. Visible-light-induced bromoetherification of alkenols for the synthesis of β-bromotetrahydrofurans and tetrahydropyrans, Beilstein J. Org. Chem. 2015, 11, 31-36. UV Light-Mediated Difunctionalization of Alkenes through Aroyl Radical Addition/1,4-/1,2-Aryl Shift Cascade Reactions, Org. Lett. 2015, 17, 1034-1037. Visible Light-Mediated Arylalkylation of Allylic Alcohols through Concomitant 1,2-Aryl Migration, Chem. Commun. 2015, 51, 4910-4913. Difunctionalization of Alkenes via the Visible-Light-Induced Trifluoromethylarylation/1,4-Aryl Shift/Desulfonylation Cascade Reactions. J. Org. Chem., 2015, 80, 5730-5736. Metal-Free Direct Aryltrifluoromethylation of Allylic Alcohols with Langlois Reagent through Concomitant 1,2-Aryl Migration, Asian J. Org. Chem. 2015, 4, 674-677. 会议论文及发表演说 “Electrochemically Assisted Photocatalytic Degradation of Pesticide Wastewater by Using the Self-Made Pilot Plant”,Adv. Mater. Res. 2012,356-360/1277-1280 “Research of photocatalytic degration of pesticide with sulfonated beta-cyclodextrin ”, Adv. Mater. Res. 2011,183-185/1442-1445

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中国化学会高级会员,国家科技奖励评审专家,国家自然科学基金通讯评议人,高校博士点基金评议人,博士后基金评议人,教育部学位与研究生教育评审专家,广西省科技项目评审专家,全国研究生教育评估监测专家

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