史雷 - 哈尔滨工业大学（深圳）

个人简介

史雷，教授，博士生导师。2012年入选“教育部新世纪优秀人才支持计划”（2013年-2015年）；2022年1月起中国化学会高级会员。 2005年6月博士毕业于兰州大学化学化工学院（导师：涂永强教授）。2005年9月至2011年9月先后在德国亚琛工业大学、德国慕尼黑大学以及英国牛津大学从事博士后研究。2011年10月至2017年5月受聘哈尔滨工业大学。2017年6月起入职哈尔滨工业大学（深圳）理学院。研究方向为基于氧化/还原策略的新试剂、新反应及机理研究，基于重要优势骨架的不对称催化合成研究。教育经历 1996.09-2005.06 兰州大学本科至博士研究与工作经历 2005.09-2006.06 德国亚琛工业大学，博士后 2006.09-2009.02 德国慕尼黑大学，洪堡学者 2009.09-2011.09 英国牛津大学，欧盟玛丽居里研究员 2011.10-2017.05 哈尔滨工业大学，教授，博导 2017.06--- 哈尔滨工业大学（深圳），教授，博导

研究领域

基于氧化/还原策略的新试剂、新反应及机理研究基于重要优势骨架的不对称催化合成研究

近期论文

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K. Fu,+ X. Yang,+ Z. Yu, L. Song*, L. Shi* Revealing the Nature of Covalently Tethered Distonic Radical Anions in the Generation of Heteroatom-Centered Radicals: Evidence for the Polarity-Matching PCET Pathway Chem. Sci. 2024, 15(31), 12398-12409. T. Yuan, K. Fu, L. Shi* Palladium(II)-Catalyzed Intramolecular C–H Amination to Carbazole: Crucial Role of Cyclic Diacyl Peroxides Org. Chem. Front. 2024, 11(16), 4529-4538. C. Wei, Z. Yu, L. Shi* Two Catalytic Protocols for the Synthesis of CF2-Containing Quinazolinones via Domino Reaction Adv. Synth. Catal. 2024, 366(14), 3181-3187. X. Yang, H. Gao, J. Yan, J. Zhou*, L. Shi* Intramolecular Chaperone-Assisted Dual-Anchoring Activation (ICDA): A Suitable Preorganization for Electrophilic Halocyclization Chem. Sci. 2024, 15(16), 6130-6140. J.-J. Yin, Y.-P. Wang, J. Xue, F.-F. Zhou, X.-Q. Shan, R. Zhu, K. Fang, L. Shi*, S.-Y. Zhang, S.-H. Hou*, W.-J. Xia, Y.-Q. Tu* Total Synthesis of Polycyclic Diterpenes Phomopsene, Methyl Phomopsenonate, and iso-Phomopsene via Reorganization of C–C Single Bonds J. Am. Chem. Soc. 2023, 145(39), 21170-21175. Z. Zhan,+ J. Yan,+ Z. Yu, L. Shi* Recent Advances in Asymmetric Catalysis Associated with B(C6F5)3 Molecules 2023, 28(2), 642. X.-H. Yang, H.-W. Gao, J. Yan and L. Shi* Recent Progress in Radical-Mediated Si-H Functionalization of Silanes: An Effective Strategy for Synthesis of Organosilanes Containing C-Si Bond 自由基介导的硅烷Si-H 键官能团化研究进展：一种合成含C-Si键有机硅化合物的有效策略 Chin. J. Org. Chem. 2022, 44, 106023/cjoc202207047. Z. Yu and L. Shi* Synthetic routes to bicyclo[1.1.1]pentylamines: booming toolkits for drug design Org. Chem. Front. 2022, 9(13), 3591-3597. S. Gan, J. Yin, Z. Yu, L. Song* and L. Shi* A one-pot and two-stage Baeyer-Villiger reaction using 2,2'-diperoxyphenic acid under biomolecule-compatible conditions Green. Chem. 2022, 24(5), 2232-2239. R. L.-Y. Bao, L. Shi* and K. Fu Highly enantioselective construction of CF3-bearing all-carbon quaternary stereocenters: Chiral spiro-fused bisoxaoline ligands with 1,1'-binaphthyl sidearm for asymmetric Michael-type Friedel-Crafts reaction Chin. Chem. Lett. 2022, 33(5), 2415-2419. X.-H. Yang, D. Chang, R. Zhao and L. Shi* Recent Advances and Uses of (Me4N)XCF3(X = S, Se) in the Synthesis of Trifluoromethylthiolated andTrifluoromethylselenolated Compounds Asian J. Org. Chem., 2021, 10(1), 61-73. R. Zhao, K. Fu, Y. Fang, J. Zhou* and L. Shi* Site-Specific C(sp3)-H Aminations of Imidates and Amidines Enabled by Covalently Tethered Distonic Radical Anions Angew. Chem. Int. Ed., 2020, 59(46), 20682–20690. D. Zhu, S. Gan, R. L.-Y. Bao and L. Shi* Copper-catalyzed cross-coupling of vinyliodonium salts and diboron reagents to generate alkenyl boronic esters Org. Biomol. Chem., 2020, 18(29), 5567-5570. R. Zhao and L. Shi* Reactions between Diazo Compounds and Hypervalent Iodine(III) Reagents Angew. Chem. Int. Ed., 2020, 59(30), 12282–12292. R. L.-Y. Bao+, J. Yin+, L. Shi* and L. Zheng Rh(I)-Catalyzed enantioselective and scalable [4 + 2] cycloaddition of 1,3-dienes with dialkyl acetylenedicarboxylates Org. Biomol. Chem., 2020, 18(15), 2956-2961. L. Shi*, R. L.‐Y. Bao, L. Zheng and R. Zhao B(C6F5)3‐Catalyzed Reduction of Cyclic N‐Sulfonyl Ketimines Eur. J. Org. Chem., 2019, 2019(38), 6550–6556. Y. Fang, R. Zhao, Y. Yao, Y. Liu, D. Chang, M. Yao and L. Shi* Trichloroacetonitrile as an efficient activating agent for the ipso-hydroxylation of arylboronic acids to phenolic compounds Org. Biomol. Chem., 2019, 17(32), 7558–7563. R. Zhao and L. Shi* A renaissance of ligand-to-metal charge transfer by cerium photocatalysis Org. Chem. Front., 2018, 5(20), 3018-3021. D. Zhu and L. Shi* Ni-catalyzed cross-coupling of aryl thioethers with alkyl Grignard reagents via C–S bond cleavage Chem. Commun., 2018, 54(67), 9313-9316. C. Wei, R. Zhao, Z. Shen, D. Chang and L. Shi* Two Catalytic Protocols for Achmatowicz Rearrangement by Using Cyclic Diacyl Peroxides as Oxidants Org. Biomol. Chem., 2018, 16(31), 5566-5569. D. Chang, F. Gao and L. Shi* Potassium tert-butoxide-mediated generation of arynes from o-bromoacetophenone derivatives Tetrahedron, 2018, 74(20), 2428-2434. Y. Zhang, L. He and L. Shi* Asymmetric hydrogenolysis of racemic 3-substitued-3-hydroxy-isoindolin-1-ones employing SPINOL-derived chiral phosphoric acid Tetrahedron Lett., 2018, 59(16), 1592-1595. Y. Zhang, L. He and L. Shi* Chiral Ion-pair Organocatalyst-Promoted Efficient Enantioselective Reduction of α-Hydroxy Ketones Adv. Synth. Catal., 2018, 360(10), 1926-1931. D. Chang, R. Zhao, C. Wei, Y. Yao, Y. Liu and L. Shi* Sulfonamide-Directed Chemo- and Site-Selective Oxidative Halogenation/Amination Using Halogenating Reagents Generated in situ from Cyclic Diacyl Peroxides J. Org. Chem., 2018, 83(6), 3305-3315. D. Zhu, Y. Yao, R. Zhao, Y. Liu and L. Shi* Metal-Free Geminal Difunctionalization of Diazocarbonyl Compounds: A One-Pot Multicomponent Strategy for the Construction of α,β-Diamino Carbonyl Derivatives Chem. Eur. J., 2018, 24(19), 4805-4809. F. Ding, Y. Jiang, K. Lin and L. Shi* Tandem radical cyclization for the construction of 1-difluoroalkylated isoquinolines via Cu catalyzed and visible light-promoted pathways Org. Biomol. Chem., 2018, 16(11), 1812-1815. F. Ding, Y. Fang, Y. Jiang, K. Lin and L. Shi* Tandem Radical Cyclization for the Construction of Difluoro-Containing Oxindoles and Quinoline-2,4-diones Chem. Asia. J., 2018, 13(6), 636-640. R. Zhao+, Y. Yao+, D. Zhu, D. Chang, Y. Liu and L. Shi* Visible-Light-Enhanced Ring Opening of Cycloalkanols Enabled by Bronsted Base-Tethered Acyloxy Radical Induced Hydrogen Atom Transfer-Electron Transfer Org. Lett., 2018, 20(4), 1228-1231. F. Ding, Y. Zhang, R. Zhao, Y. Jiang, R. L.-Y. Bao, K. Lin and L. Shi* B(C6F5)3-promoted hydrogenations of N-heterocycles with ammonia borane Chem. Commun., 2017, 53(66), 9262-9264. Y. Zhang, Y. Yao, L. He, Y. Liu and L. Shi* Rhodium(II)/Chiral Phosphoric Acid Co-Catalyzed Enantioselective O–H Bond Insertion of α-Diazoesters (as VIP) Adv. Synth. Catal., 2017, 359(16), 2754-2761. R. Zhao, D. Chang and L. Shi* Recent Advances in Cyclic Diacyl Peroxides: Reactivity and Selectivity Enhancement Brought by Cyclic Structure Synthesis., 2017, 49(15), 3357-3365. F. Ding, Y. Jiang, S. Gan, R. L.-Y. Bao, K. Lin and L. Shi* B(C6F5)3-Catalyzed Deoxygenation of Sulfoxides and Amine N-Oxides with Hydrosilanes Eur. J. Org. Chem., 2017, 2017(24), 3427-3430. S. Gan, J. Yin, Y. Yao, Y. Liu, D. Chang, D. Zhu and L. Shi* Metal- and additive-free oxygen-atom transfer reaction: an efficient and chemoselective oxidation of sulfides to sulfoxides with cyclic diacyl peroxides Org. Biomol. Chem., 2017, 15(12), 2647-2654. D. Zhu, D. Chang, S. Gan and L. Shi* Direct α-acyloxylation of organic sulfides with the hypervalent (diacyloxyiodo)benzene/tetra-n-butylammonium bromide (TBAB) reagent combination RSC Adv., 2016, 6(33), 27983-27987. D. Chang, D. Zhu and L. Shi* [3+2] Cycloadditions of Azides with Arynes via Photolysis of Phthaloyl Peroxide Derivatives J. Org. Chem., 2015, 80(11), 5928-5933. S. Kong, L. Zhang, X. Dai, L. Tao, C. Xie, L. Shi* and M. Wang* DDQ-mediated Direct C(sp3)-H Cyanation of Benzyl Ethers and 1,3-Diarylpropenes under Solvent- and Metal-free Conditions Adv. Synth. Catal., 2015, 357(11), 2453-2456. Y. Zhang, R. Zhao, R. L.-Y. Bao and L. Shi* Highly Enantioselective SPINOL-Derived Phosphoric Acid Catalyzed Transfer Hydrogenation of Diverse C=N-Containing Heterocycles Eur. J. Org. Chem., 2015, 2015(15), 3344-3351. D. Zhu, D. Chang and L. Shi* Transition-metal-free cross-coupling of thioethers with aryl(cyano)iodonium triflates: a facile and efficient method for the one-pot synthesis of thiocyanates Chem. Commun., 2015, 51(33), 7180-7183. R. L.-Y. Bao, R. Zhao and L. Shi* Progress and developments in the turbo Grignard reagent i-PrMgCl·LiCl: a ten-year journey Chem. Commun., 2015, 51(32), 6884-6900. D. Chang, D. Zhu, P. Zou and L. Shi* Cleavage of C-N bonds in guanidine derivatives and its relevance to efficient C-N bonds formation Tetrahedron, 2015, 71(11), 1684-1693. R. Zhao and L. Shi* Promising Combination for Asymmetric Organocatalysis: Bronsted Acid-Assisted Chiral Phosphoric Acid Catalysis ChemCatChem., 2014, 6(12), 3309-3311.